Prevalence and predictors of irritable bowel syndrome in patients with morbid obesity: a cross-sectional study

Aasbrenn, Martin; Høgestøl, Ingvild Kristine Dahl; Eribe, Inger; Kristinsson, Jon; Lydersen, Stian; Mala, Tom; Farup, Per G.

doi:10.1186/s40608-017-0159-z

Cited by 35 publications

(34 citation statements)

References 31 publications

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“…This finding confirms results coming from a population based-study showing a relationship between BMI and GI symptoms such as diarrhea [4]. Several factors are common in both obesity and IBS, such as a diet with high amount of refined carbohydrates, or lipids, and low in fiber, disorder of intestinal motility, gut microbiota alteration and inflammation which may explain the link between the two clinical conditions [38].…”

Section: Functional Dyspepsia (Fd)supporting

confidence: 88%

“…In the meantime, few studies explored the association between obesity and IBS. Data from literature have failed to show a possible association between IBS subtypes prevalence and BMI [37], however among IBS patients, those with abdominal obesity likely report frequent symptoms even after correction for possible confounders [38].…”

Section: Functional Dyspepsia (Fd)mentioning

confidence: 99%

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Role of Overweight and Obesity in Gastrointestinal Disease

et al. 2019

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The prevalence of obesity is increasing worldwide, leading to a severe impairment of overall health. Actually, obesity has been associated with several pathological conditions, causing an excess overall mortality. In particular, overweight and obesity are well known risk factors for a variety of gastrointestinal (GI) disorders i.e., functional GI disorders as well as, inflammatory bowel disease (IBD), pancreatitis, and GI cancer. The aim of the present review is to summarize the potential role of overweight and obesity in GI disease with particular focus on plausible biological mechanisms that could explain the association between obesity and GI disease based on the most recent evidence in the literature.

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Section: Functional Dyspepsia (Fd)supporting

confidence: 88%

Section: Functional Dyspepsia (Fd)mentioning

confidence: 99%

Role of Overweight and Obesity in Gastrointestinal Disease

et al. 2019

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“…Panova et al [4] a combination of obesity with dyskinesia of the colon, diverticular disease, and polyposis of the large intestine were diagnosed in 36.28; 28.0; 10.0% of patients respectively. A more frequent combination of obesity and irritable bowel syndrome with constipation (IBSc) was also found by M. Aasbrenn et al [5]. The prevalence of IBS in obese patients varies in the studied population and ranges from 11.6 to 24.0% in adults [6].…”

Section: Introductionmentioning

confidence: 70%

Efficiency of synthetic melatonin in comprehensive therapy of patients with a combination of irritable bowel syndrome with constipation, arterial hypertension and obesity

Mishchuk¹,

Grygoruk²,

Hubina³

et al. 2019

Ro J Med Pract.

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Introduction. The problem of pathology of internal organs comorbidity with obesity has become particularly relevant in recent years. The association of obesity with gastrointestinal pathology, in particular, irritable bowel syndrome has not been studied enough. The role of melatonin in the development of these diseases and the possibility of using its synthetic forms in their treatment has drawn the attention of researchers in recent years. Objective-to study the effect of synthetic melatonin on blood pressure, autonomic status, sleep quality, the level of ghrelin and serotonin in patients suffering from obesity combined with arterial hypertension and irritable bowel syndrome with constipation. Material and methods. The study involved 78 patients, of which 34 were diagnosed with irritable bowel syndrome with constipation combined with obesity, and 54 of those who suffered obesity, irritable bowel syndrome combined with arterial hypertension. Patients of each group were divided into two subgroups depending on the treatment complex, one of which received standard therapy, and in the case of combination with arterial hypertension, they also received three component antihypertensive therapy, while the other two received synthetic melatonin before the standard therapy. Results. There was a more significant decrease in average daily systolic and diastolic blood pressure values under the influence of therapy with the inclusion of vitae-melatonin and a significant decrease in the number of patients with a non-dipper and night-picker blood pressure profile. The more positive influence of comprehensive therapy with the inclusion of melatonin on parameters of heart rate variability and its quality was noted. The administration of melatonin combined with a standard therapy led to an increase in the frequency of the bowel movement, approaching serotonin in the serum to normal rates and a decrease in the postprandial level of ghrelin without changes in its fasting concentration. Conclusions. The obtained results are indicative of the positive effect of melatonin on obesity combined with irritable bowel syndrome with constipation and arterial hypertension.

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“…However, there is a lack of studies investigating associations between perceived intolerance against particular foods and the corresponding s-IgG or s-IgA food antibodies in adults with GI symptoms. The present study addressed this issue in subjects with morbid obesity, a patient group with reportedly high prevalence of gastrointestinal symptoms, including IBS [ 12 – 14 ]. Interestingly, IBS and obesity also have several pathophysiological features in common, including increased gut permeability [ 15 , 16 ], which could potentially result in increased translocation of food antibodies.…”

Section: Introductionmentioning

confidence: 99%

Is perceived intolerance to milk and wheat associated with the corresponding IgG and IgA food antibodies? A cross sectional study in subjects with morbid obesity and gastrointestinal symptoms

2018

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BackgroundSerum IgG and IgA food antibodies have been used for dietary advice to subjects with gastrointestinal symptoms and perceived food intolerance, but the role of these antibodies in mediating intolerance is controversial. The present study investigated associations between perceived gastrointestinal intolerance to milk-or wheat and the corresponding s-IgG and s-IgA food antibodies in subjects with morbid obesity.MethodsSubjects with morbid obesity (BMI ≥ 40 kg/m2 or ≥35 kg/m2 with obesity-related complications) were included. Irritable Bowel Syndrome (IBS) was diagnosed based on the Rome III criteria. Severity of specific gastrointestinal symptoms were measured with the Gastrointestinal Symptom Rating Scale (GSRS)-IBS. S-IgG against cow’s milk, cheese, wheat and gluten, and s-IgA against casein and gliadin were measured.ResultsNinety-seven subjects (80 females) with mean age 45 (SD 8.4) years were included, 70 had gastrointestinal complaints, 25 had IBS, and 22 and 20 reported milk- and wheat- intolerance respectively. There were no significant differences in serum concentrations or proportions of subjects above defined cut-off values for the antibodies between subjects with and without gastrointestinal complaints. In the group with gastrointestinal complaints, no significant differences were found between subjects with and without perceived food intolerance. Except for a significant correlation between IgG against cheese and GSRS-diarrhea (Rho: -0.25, P = 0.04), no significant correlations were found between the antibodies and type or degree of gastrointestinal symptoms, including IBS.ConclusionsThe study showed no associations between perceived milk or wheat intolerance and the corresponding s-IgG and s-IgA food antibodies in subjects with morbid obesity.

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Prevalence and predictors of irritable bowel syndrome in patients with morbid obesity: a cross-sectional study

Cited by 35 publications

References 31 publications

Role of Overweight and Obesity in Gastrointestinal Disease

Role of Overweight and Obesity in Gastrointestinal Disease

Efficiency of synthetic melatonin in comprehensive therapy of patients with a combination of irritable bowel syndrome with constipation, arterial hypertension and obesity

Is perceived intolerance to milk and wheat associated with the corresponding IgG and IgA food antibodies? A cross sectional study in subjects with morbid obesity and gastrointestinal symptoms

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