Prevalence and Predictors of Left Ventricular Diastolic Dysfunction in a Hispanic Patient Population

Abstract

Minimal data exist on attributes of diastolic dysfunction in the Hispanic population. The purpose of this study was to evaluate the prevalence and predictors of diastolic dysfunction in a Hispanic patient population. We performed a retrospective review of 166 consecutive echocardiograms in a southwestern Texas Hospital that caters to a large Hispanic patient population. We identified all echocardiograms that met criteria for diastolic dysfunction and assessed baseline demographics and comorbidities in the cohort of Hispanic patients. A multivariate analysis was performed to identify the independent predictors of diastolic dysfunction. A total of 129 out of 166 patients (77.8%) were of Hispanic origin. Out of the 129 patients, 87 (67.4%) had some degree of diastolic dysfunction in this population suggesting a high prevalence in the study cohort. In the diastolic dysfunction group, the mean age was 64.5 ± 13.9, 37% were male and 63% female, 78% had diabetes, 85% had hypertension, and 49% had some degree of renal insufficiency (stages 3-5). A logistic multivariate analysis showed that diabetes was an independent predictor of diastolic dysfunction with odds ratio of 2.69 (95% confidence interval [CI], 1.06-6.28; p = 0.038). Similarly age (per year increase) and chronic kidney disease were independent predictors of diastolic dysfunction. We demonstrated that older age, presence of diabetes, and renal dysfunction are independent predictors of diastolic dysfunction in the Hispanic patient population. Strategies geared toward reducing diabetes and preventing renal dysfunction are likely to decrease prevalence of diastolic dysfunction and heart failure in this community.

Burden of Systolic and Diastolic Left Ventricular Dysfunction Among Hispanics in the United States

“…Thus the high prevalence of LVDD in the ECHO-SOL community based study population is surprising. Castro et al 34 reported on LVDD prevalence among Hispanics/Latinos in southwest Texas by doing a retrospective analysis of 166 consecutive echocardiogram from a hospital database. 129 of 166 (77.8%) were Hispanics/Latinos; 87 of 129 (67.4%) has some degree of LVDD.…”

Pilot Study; Estimating Sample Size for the Prevalence of Pre-Clinical Left Ventricular Diastolic Dysfunction Using Two American College of Echocardiography Guidelines in a Semi-Urban Nigerian Population

“…Prevalence of LVDD in a general population from previous studies [19,20,21,22] outside the African continent varied from 11.1 -67.4% depending on the population characteristics and diagnostic criteria. The prevalence in a German study [19] dropped to 3.1% when left atrial enlargement was considered.…”

Predictors of adverse diastolic remodeling in non-diabetic patients presenting with ST-elevation myocardial infarction

“…Prolonged coronary occlusion can result in loss of anatomic integrity in the microvascular network and abnormalities in coronary microvascular function are known to cause ischemia even in the absence of epicardial stenosis [ 33 , 34 ]. Diabetes mellitus is also a well-established cardiovascular risk factor for the development of diastolic dysfunction [ 9 , 10 ]. Although we excluded diabetic patients from our study, our findings still show that an increased plasma glucose level is associated with worse diastolic function.…”

“…This suggests that the effects of age and hypertension might have already affected diastolic function parameters in the first measurement. In epidemiological studies in the general population, age and hypertension have previously been observed to be independent risk factors for deterioration of diastolic function [ 9 , 10 ].…”

“…Several risk factors, notably hypertension and diabetes, have been identified as predictors of diastolic dysfunction in the general population [ 9 , 10 ]. However, little is known about the elements that are specifically related with diastolic function following myocardial remodeling after MI.…”