Prevalence and Predictors of Overweight and Obesity in Patients with Pituitary Dysfunctions

Harbeck, Birgit; Danneberg, Sven; Rahvar, Amir H; Mönig, H.; Haas, Christian

doi:10.2174/1871530316666161130160809

Cited by 4 publications

(5 citation statements)

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“…It has already been observed that more often patients with macroadenomas are significantly overweight and obese than individuals with microadenomas. [26] Perhaps this finding may explain the higher frequency of obesity in acromegalics in this series, 94.1% of them with macroadenomas, in relation to individuals with Cushing's disease, 60% with macroadenomas.…”

Section: Discussionmentioning

confidence: 73%

“…Schmid et al[25] investigated 399 adenomas and found that 22.2% of patients with Cushing's disease, 21.4% of patients with acromegaly, and 17% of patients with clinically nonfunctioning adenomas were obese. Harbeck et al[26] observed a higher prevalence of BMI ≥25 in prolactinomas (70%). In the present study, a higher percentage of obesity was found in patients with acromegaly (46.7%).…”

Section: Discussionmentioning

confidence: 99%

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Assessment of anthropometric and physical health indicators before and after pituitary surgery in patients with nonfunctioning pituitary adenomas, acromegaly, and Cushing disease

Leães

Fernandes

Alves

et al. 2019

Indian J Endocr Metab

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Introduction:Individuals with pituitary adenomas may have organic consequences of their disease or therapy, and psychological changes can compromise their quality of life (QoL). This study aimed to determine the anthropometric profile and health indicators of patients with pituitary adenoma before and after pituitary surgery.Methods:Forty-four patients were included in this study. Out of these, 22 patients had nonfunctioning adenomas (50%), 17 acromegaly (38.6%), and 5 patients with Cushing's disease (11.4%). Anthropometric measurements included body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR). Health indicators included body fat percentage (BF%), basal metabolic rate (BMR), maximal oxygen uptake (VO2 max), and hand grip strength. Physical activity level (the International Physical Activity Questionnaire [IPAQ]), subjective perception of health, body image (Body Shape Questionnaire), body satisfaction (Stunkard Figure Rating Scale) were used.Results:The mean patient age was 47.2 ± 14.6 years; of which 25 were women (56.8%). Before surgery, 75.0% were overweight or obese, 84.1% had WC with risk of metabolic complications, and 90.0% had WHR with cardiovascular risk. There was a high BF% in 56.4% of cases, low BMR in 65.1%, lower VO2 max in 16.2%, and below-average grip strength in 88.6%. Hypopituitary patients had poorer cardiorespiratory fitness. The IPAQ showed reduction in physical activity, and 79.5% of patients were dissatisfied with their body image. Patients with nonfunctioning adenomas had better perception of their health while those with Cushing's disease had more distorted body image. Postoperatively, patients with acromegaly showed improvement in WHR and physical activity level, and patients with Cushing's disease showed improvement in anthropometric variables.Conclusions:These findings emphasize the need for continuous monitoring of this population for anthropometric indicators associated with metabolic and cardiovascular comorbidities as well as body satisfaction.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Assessment of anthropometric and physical health indicators before and after pituitary surgery in patients with nonfunctioning pituitary adenomas, acromegaly, and Cushing disease

Leães

Fernandes

Alves

et al. 2019

Indian J Endocr Metab

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“…Additionally, as Harbeck et al report [21], apparently, body weight is not in uenced by hormonal activity in PA patients, since both individual with hormone secreting tumors and controls suffer from overweight or obesity. This was con rmed by our results, where we did not nd differences in weight between PA types.…”

Section: Surgery Success Strati Cation Outcomesmentioning

confidence: 94%

“…Only a few reports mention similar ndings, for example, Cheng et al reported that PA invasiveness or size did not associate proportionally with abnormal glucose metabolism [20]. Moreover, Harbeck and colleagues only report differential prevalence of overweight and obesity between patients with macro and microadenomas, with a higher prevalence in individuals with macroadenomas [21].…”

Section: Surgery Success Strati Cation Outcomesmentioning

confidence: 96%

Improvement of metabolic syndrome and its components in patients who underwent transsphenoidal resection for pituitary adenoma

Cortés-Contreras,

Salazar-Pigeon,

González-Almazán

et al. 2024

Acta Neurochir

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Purpose. The aim of this paper is to evaluate changes in the metabolic status of patients with PA before and after the surgical treatment, and to look for differences in the metabolic outcomes among patients according to the adenoma type and the success rate of the surgery.Methods. We assessed patients with PA who went through TSS for its treatment, documenting metabolic parameters (height, weight, fasting glucose, blood pressure, triglycerides, and HDL-cholesterol) before and after surgery, analyzed whole sample changes, and then strati ed them according to adenoma type (nonproducing, somatotroph, lactotroph, and corticotroph), and surgery success (total resection, near total resection, partial resection, subtotal resection).Results. A total of 214 patients were enrolled for this study. The prevalence of MetSx with AACE criteria went from 51.52% before surgery to 28.99% after surgery (p <0.001). Hyperglycemia was the most bene ted component, which went from 56% pre-surgery to 40.51% post-surgery (p= 0.03). Total resection group had the best improvement, with signi cant decrease of prevalence in MetSx from 83% to 16% (p< 0.001), and every component, excepting Hα: obesity went from 96% to 67% (p< 0.001), HT 59 to 24% (p< 0.001), HGlu 74 to 23 % (p<0.001), and HTri from 81 to 54% (p< 0.001). According to MetSx prevalence, there was no difference of the improvement PA type, as this improvement showed to be signi cant in all of them. Conclusion. MetSx improves in patients with PA after surgical treatment.Trial registration number.

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“…The young female cased associated obesity and macroprolactinoma. Some studies pointed out that the patients with prolactin producing macroadenomas have a higher risk of obesity (independent of features related to central hypogonadism), but it is not a general observation (10,11).…”

Section: Prolactinoma and Obesitymentioning

confidence: 99%

From skin infections to bariatric surgery in patients with endocrine tumours

Şandru¹,

Valea²,

Albu³

et al. 2019

Ro Med J.

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Obesity is associated with multiple complications like cardiovascular, oncologic, including skin infections potentially with a more severe evolution than in subjects with normal weight. We aim is to introduce two cases of females who initially presented with skin infections associating obesity and two different types of endocrine tumours; both of them underwent bariatric surgery. One case of a young female who had acne and menses anomalies was confirmed with macroprolactinoma and treated with cabergoline with menses control. For obesity she had bariatric surgery with weight and acne control but associating long term hypovitaminosis D. The second case is a menopausal woman with metabolic syndrome and different persistent skin infections in association with features of cardio-metabolic anomalies which were confirmed as adrenal Cushing's syndrome and referred for unilateral adrenalectomy. The improvement of mentioned parameters was not associated with obesity control so bariatric surgery was done. She suffered a shoulder fracture and she was confirmed with osteoporosis (a lumbar T-score of -3.3 SD). The values of 25-hydroxyvitamin D remained normal only under oral replacement with vitamin D supplements and zolendronic acid was added. Obesity underlines heterogeneous aspects including dermatological, metabolic, cardiovascular and endocrine conditions; some of them are dramatically improved after bariatric surgery, yet not hipovitaminosis D and osteoporosis especially in menopausal women. The prolactin excess, Cushing's disease or just obesity itself may cause repeated skin infections or acne. abbreviations BMI = body mass index DXA = Dual-Energy X-Ray Absorptiometry SD = standard deviation RefeRenCeS

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Prevalence and Predictors of Overweight and Obesity in Patients with Pituitary Dysfunctions

Cited by 4 publications

References 0 publications

Assessment of anthropometric and physical health indicators before and after pituitary surgery in patients with nonfunctioning pituitary adenomas, acromegaly, and Cushing disease

Assessment of anthropometric and physical health indicators before and after pituitary surgery in patients with nonfunctioning pituitary adenomas, acromegaly, and Cushing disease

Improvement of metabolic syndrome and its components in patients who underwent transsphenoidal resection for pituitary adenoma

From skin infections to bariatric surgery in patients with endocrine tumours

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