Prevalence and predictors of peripheral arterial disease determined by ankle brachial index in diabetes population treated within primary care services in a non-urban area of lower northern Thailand

Suwannasrisuk, Preaw; Sattanon, Sarinya; Taburee, Watcharaporn; Singkheaw, Pantitra; Sowanna, Non; Boonprasert, Phimnipha; Boonrueng, Umpapun; Wong, Peerapon

doi:10.1177/1479164120966997

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…The ABI is a useful tool for identifying peripheral arterial disease [37], macroangiopathy including CAD, arteriosclerosis obliterans and stoke [38]. Subclinical arteriosclerosis assessed by carotid atherosclerosis was referred to as atherosclerosis [39].…”

Section: Discussionmentioning

confidence: 99%

The ApoB/A-1 ratio is independently associated with subclinical arteriosclerosis and arterial stiffness in type 2 diabetes patients

Tang

Shen

et al. 2022

Preprint

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Background The ApoB/ApoA-1 (ApoB/A1) ratio is a predictor of atherosclerotic vascular disease. In this study, we aimed to explore whether ApoB/A1 ratio is related to arteriosclerosis parameters, including subclinical atherosclerosis and arterial stiffness, in type 2 diabetic patients. Methods In this cross-sectional study, 256 type 2 diabetic (T2D) patients, including 152 patients with carotid atherosclerosis, were recruited. Traditional fasting lipid profiles and ApoB and ApoA-1 levels were measured. Arterial stiffness was assessed by brachial ankle pulse wave velocity (baPWV), and subclinical arteriosclerosis was assessed by ankle brachial index (ABI) and carotid atherosclerosis. Results The ApoB/A1 ratio in T2D patients with no carotid atherosclerosis was significantly higher than that in T2D patients with carotid atherosclerosis (p < 0.05). The arterial stiffness parameters baPWV and ABI were significantly lower among T2D patients with no carotid atherosclerosis (all p < 0.05). Moreover, the baPWV and ABI were significantly decreased across the ApoB/A1 ratioquartiles (all p for trend < 0.05). Additionally, baPWV and ABI were both inversely related to ApoB/A1 ratio (r = –0.223 and –0.224, respectively, p < 0.001). Using univariate logistic regression analyses, ApoB/A1 ratio, sex, age, duration, baPWV, HbA1c, and statin use were found to be independent contributors to carotid atherosclerosis, and the corresponding odds ratios (95% confidence intervals) were 0.242 (0.090–0.646), 0.326 (0.178–0.599), 2.730 (1.619–4.603), 6.833 (3.024–15.44), 1.204 (1.103-1.314), 0.842 (0.745-0.953),and 2.704 (1.228, 5.954), respectively. After adjusting for clinical covariates by multiple logistic regression analyses, the corresponding odds ratio (OR) for the ApoB/A1 ratio of carotid atherosclerosis was 0.216 (0.062-0.759). Conclusions The ApoB/A1 ratio was independently and inversely associated with baPWV and ABI and independently contributed to carotid atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

The ApoB/A-1 ratio is independently associated with subclinical arteriosclerosis and arterial stiffness in type 2 diabetes patients

Tang

Shen

et al. 2022

Preprint

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Type 2 Diabetes Mellitus Complications: A Thai real-world clinical cohort (Preprint)

Looareesuwan¹,

Boonmanunt²,

Thammasudjarit³

et al. 2022

Preprint

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BACKGROUND Type 2 diabetes (T2D) is a major non-communicable disease that can progress to multiple complications that lead to significant burden at both individual and population levels. Understanding disease progression and transition between complication states will inform appropriate treatment and management strategy planning. This T2D cohort was ascertained to estimate the transition probabilities of diabetic complications. OBJECTIVE The aim of this study is to construct the T2D cohort profile and estimate the transition probabilities. METHODS This T2D cohort was based on routine clinical practice data collected from Ramathibodi Hospital, Bangkok, Thailand from 2010 to 2019. Adults with newly diagnosed T2D were considered eligible for inclusion if they were followed up on at least two occasions. Outcomes of interest included diabetic retinopathy (DR), chronic kidney disease (CKD), cardiovascular disease (CVD), peripheral vascular disease (PVD) and mortality. These data were identified from multiple sources and combined with laboratory and medication prescribing data. Ten-year transition probabilities were calculated by Kaplan-Meier estimates. RESULTS Of 40,662 incident T2D cases, the incidence rate/100 patients/year (95% confidence intervals [CI]) for CKD, CVD, DR, PVD and death were 3.3 (3.1-3.3), 2.7 (2.6-2.8), 1.6 (1.5-1.63), 0.50 (0.49-0.56), and 0.58 (0.54-0.62), respectively. The transition probabilities from a baseline complication-free T2D state to these corresponding states at 10 years were 0.26 (0.21-0.33), 0.19 (0.15-0.23), 0.13 (0.11-0.15), 0.03 (0.03-0.04), and 0.03 (0.02-0.04), respectively. CONCLUSIONS This well-characterized T2D cohort based on 10-year clinical practice data identified CKD as the most likely T2D complication, followed by CVD and DR. Further studies that consider prognostic factors, treatment safety and effectiveness, and economic evaluation will further guide treatment management and planning strategies in the Thai population.

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Prevalence and predictors of peripheral arterial disease determined by ankle brachial index in diabetes population treated within primary care services in a non-urban area of lower northern Thailand

Cited by 2 publications

References 6 publications

The ApoB/A-1 ratio is independently associated with subclinical arteriosclerosis and arterial stiffness in type 2 diabetes patients

The ApoB/A-1 ratio is independently associated with subclinical arteriosclerosis and arterial stiffness in type 2 diabetes patients

Type 2 Diabetes Mellitus Complications: A Thai real-world clinical cohort (Preprint)

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