Prevalence and predictors of potential drug–drug interactions in Regione Emilia-Romagna, Italy

Abstract

A substantial number of clinically important potential DDIs were identified, particularly among warfarin users. Awareness of the most prevalent potential DDIs can help practitioners prevent concomitant use of these dangerous medication combinations.

Prevalence and predictors of potential drug-drug interactions

“…In the study conducted in Brazilian primary public health system the most commonly drug pairs were digoxin and furosemide/hydrohlorothiazide, captopril/losartan and spironolactone, and acidum acetylsalicylicum and ticlopidine [22]. In ambulatory medical care practices in the US, Aparasu et al identified that warfarin included in the three most commonly DDIs pairs [17], similar to the results of study was conducted in Italian outpatients [31].…”

“…These findings could be attributed to the increased complexity of drug therapy regimens found in older, which resulted in a higher prevalence of potential DDIs. However, in the study conducted by Gagne et al in Italy, using subjects aged 50-64 years as a referent group, the odds of exposure to a potential DDIs was higher in older patients, however odds of exposure for the oldest (aged ≥ 85 years, OR=2.02 (95% CI of 1.66-2.46)) was lower than for those aged of 65-74 years [31]. Some studies failed to document a positive association between years and exposure to potential DDIs [45,46].…”

“…For each patient, the number drugs prescribed and ATC code classification of drug therapy were analyzed as drug therapy characteristics. Selected predictor factors were chosen in accordance with the results of previous studies [22,25,28,31].…”

“…Additionally, the frequency study of potential DDIs at geriatric outpatient in 6 European countries showed that there were differences in frequency, as well as in the type of potential DDIs [23]. By study of predictors to DDIs was also observed variability, those which are patient characteristics as well as those which are therapy characteristics [20][21][22][24][25][26][27][28][29][30][31][32]. Differences in healthcare settings, registered and reimbursed pharmaceutical specialities can contribute to different utilization patterns of prescription drugs.…”

Acompanhamento Farmacoterapêutico De Pacientes Em Uso De Varfarina: Uma Revisão Da Literatura

“…Além dos eventos adversos, a varfarina está entre os fármacos com maior número de interações medicamentosas (JACOBS, 2008;BONATE et al, 2016), a maioria com importância clínica (GAGNE et al, 2008). Kotirum et al (2007) verificaram que 83,6% dos pacientes usuários de varfarina apresentam, pelo menos, uma interação medicamentosa com este medicamento.…”