Prevalence and Predictors of Preoperative Venous Thromboembolism in Asymptomatic Patients Undergoing Major Oncologic Surgery

Gainsbury, Melanie L.; Erdrich, Jennifer; Taubman, D; Mirocha, James; Manguso, Nicholas; Amersi, Farin; Silberman, Allan W.

doi:10.1245/s10434-018-6461-2

Cited by 10 publications

(12 citation statements)

References 21 publications

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“…Venous thromboembolism (VTE) is a frequent complication of cancer and is the second most common reason for death among patients with cancer 1,2 . When compared to the general population, patients with cancer show a seven times higher prevalence of thromboembolism 3 .…”

Section: Introductionmentioning

confidence: 99%

“…Venous thromboembolism (VTE) is a frequent complication of cancer and is the second most common reason for death among patients with cancer. 1,2 When compared to the general population, patients with cancer show a seven times higher prevalence of thromboembolism. 3 In pooled analyses of patients with varying types of cancer, those with tumors originating in the pancreas, stomach, brain, kidney, uterus, lung, and ovary had the highest incidence of VTE.…”

Section: Introductionmentioning

confidence: 99%

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High prevalence of pulmonary embolism prior to cancer therapies in patients with ovarian and endometrial cancers detected by contrast‐enhanced CT using D‐dimer as an index

Habu

Mitsuhashi

Hanawa

et al. 2021

Journal of Surgical Oncology

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Objective We aimed to evaluate the prevalence of pulmonary embolism (PE) before cancer therapies in patients with ovarian and endometrial cancers with enhanced computed tomography (CT) using D‐dimer (DD), and determine the optimal cut‐off level of DD. Methods Since 2009, we have performed preoperative venous thromboembolism (VTE) screening of patients with ovarian and endometrial cancer. For patients with DD levels of more than 1.0 μg/ml, enhanced CT images were obtained from the pulmonary apex to the foot to detect PE and deep venous thrombosis (DVT) simultaneously. Results Among patients with ovarian cancer, 84 of 413 (20.3%) had VTEs (DVT alone, n = 31 [7.5%]; PE with or without DVT, n = 53 [12.8%]; PE alone, n = 12 [2.9%]). Among patients with endometrial cancer, 50 of 455 (11.0%) had VTEs (DVT alone, n = 19 [4.2%]; PE with or without DVT, n = 31 [6.8%], PE alone, n = 14 [3.1%]). The optimal cut‐off level of DD was estimated to be ≥1.5 and ≥1.2 μg/ml in ovarian and endometrial cancers, respectively. Conclusion Our study revealed a high prevalence of PE before cancer therapies in patients with ovarian and endometrial cancers by enhanced CT using DD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High prevalence of pulmonary embolism prior to cancer therapies in patients with ovarian and endometrial cancers detected by contrast‐enhanced CT using D‐dimer as an index

Habu

Mitsuhashi

Hanawa

et al. 2021

Journal of Surgical Oncology

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“…A study conducted in Japan indicated that lower limb echo screening identified soleal venous thrombosis in 8.5% of patients before general abdominal surgeries, including those for benign diseases 13. Gainsbury et al recently reported that 10% of patients undergoing major oncologic surgery had evidence of VTE preoperatively,14 suggesting that the presence of preoperative VTE in cancer patients is much higher than previously thought. In the present study, we identified DVT in 19.2% of patients awaiting colorectal cancer surgery.…”

Section: Discussionmentioning

confidence: 94%

<p>Current status of venous thromboembolism development during the perioperative period for colorectal cancer, its prevention with enoxaparin, and monitoring methods</p>

Aoki¹,

Sakamoto²,

Takahashi³

et al. 2019

TCRM

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Background: There is a high incidence of venous thromboembolism (VTE) during the perioperative period for cancer. Therefore, there is an urgent need to elucidate the perioperative onset and appropriate prophylaxis for VTE. Purpose: VTE during the perioperative period for colorectal cancer was evaluated by lower limb venous ultrasonic examinations (lower limb echo) under enoxaparin prophylaxis. We also examined the relationship between hemorrhagic adverse events and anti-Xa factor activity. Patients and methods: Eighty-three subjects who underwent lower limb echo during the perioperative period for colorectal cancer were prospectively included. Enoxaparin was administered for 5 days, from day 1 to day 5 after surgery. Lower limb echo was performed before surgery and on day 5 after surgery. The activated partial thromboplastin time, D-dimer levels, and anti-Xa factor activity were measured before surgery and on days 1, 3, 5, 7, and 9 after surgery. Results: VTEs before surgery were observed on lower limb echo for 16 patients (19.2%). Three patients (3.6%) had a new thrombus during the perioperative period. The preoperative D-dimer level was an independent prognostic factor for newly formed postoperative VTEs ( p =0.0036; odds ratio, 19.37). Three patients (3.6%) had hemorrhagic events; however, there was no significant trend for anti-Xa factor activity. Conclusion: VTE prevention using enoxaparin was relatively safe, and D-dimer measurements before surgery were useful for predicting perioperative VTE.

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“…According to evidence, DVT was involved in 30% patients encountered to various interventions of abdominal and thoracic surgery. The data of postoperative DVT frequency is quite controversial (4,5). If based only on clinical data it seems insignificant.…”

Section: Introductionmentioning

confidence: 99%

“…This circumstance states the extremely high percentage of lifetime undiagnosed massive embolic complications. (3,4). We analyzed in this study superiority of combined approach of thromboprophylaxis compared to conventional nonpharmacological preventive sets.…”

Section: Introductionmentioning

confidence: 99%

Combined approach of perioperative antithromboembolic management in abdominal and thyroid surgery

Beyshenaliev¹,

Zhumagulov²,

Atabaev³

et al. 2019

HVT

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Objective: Venous thromboembolism (VTE) in the form of either pulmonary embolism (PE) or deep vein thrombosis (DVT) complicates major surgery not infrequently. We analyzed in this study superiority of combined approach of thromboprophylaxis compared to conventional nonpharmacological preventive sets. Methods: We prescribed both pharmacological and non-pharmacological thromboprophylactic interventions for patients encountered thoracoabdominal surgery from 2013 to 2018 at clinic named after I.K.Akhunbaev of Bishkek city and Interregional United Clinical Hospital of Osh city. Demographic characteristics and clinical examination data were evaluated. Thrombogenic risk for every patient was assessed. Screening for detection of VTE was conducted in early postoperative period. Results: Two hundred forty-six candidates of abdominal and thyroid surgery were divided into 2 groups according to patient preference for prevention modality: combined and non-pharmacological. In the early postoperative period, venous thrombosis of the lower extremities developed in 17 patients non-pharmacological group and 8 patients of combined interventions (p<0.05). Conclusion: Timely commenced, combined non-drug and pharmacological preventive sets for thromboembolic complications during major surgery decreases the incidence of venous thromboembolic complications.

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Prevalence and Predictors of Preoperative Venous Thromboembolism in Asymptomatic Patients Undergoing Major Oncologic Surgery

Cited by 10 publications

References 21 publications

High prevalence of pulmonary embolism prior to cancer therapies in patients with ovarian and endometrial cancers detected by contrast‐enhanced CT using D‐dimer as an index

High prevalence of pulmonary embolism prior to cancer therapies in patients with ovarian and endometrial cancers detected by contrast‐enhanced CT using D‐dimer as an index

<p>Current status of venous thromboembolism development during the perioperative period for colorectal cancer, its prevention with enoxaparin, and monitoring methods</p>

Combined approach of perioperative antithromboembolic management in abdominal and thyroid surgery

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