Prevalence and predictors of rhabdomyolysis in patients with hypophosphatemia

Singhal, Pravin C.; Kumar, Alok; Desroches, Lionel; Gibbons, Nora; Mattana, Joseph

doi:10.1016/0002-9343(92)90740-3

Cited by 109 publications

(46 citation statements)

References 12 publications

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“…The second reason contributing to the rhabdomyolysis in this case may be associated with our patient's hypophosphatemia. Hypophosphatemic patients who have received hyperalimentation, without phosphate supplementation, have been reported to be at risk for rhabdomyolysis (9). In the present case, the patient's serum phosphate level was almost within the normal range, under hyperalimentation, until day 105.…”

Section: Discussionsupporting

confidence: 53%

Rhabdomyolysis Caused by <i>Candida parapsilosis</i> in a Patient with Acute Myeloid Leukemia after Bone Marrow Transplantation

et al. 2015

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Rhabdomyolysis is characterized by a marked elevation of the creatine kinase (CK) levels and myoglobinuria, thus leading to renal dysfunction. Various viruses or bacteria can be etiologic agents, but mycosis has only rarely been reported to be a cause of rhabdomyolysis. In this report, we describe an adolescent male with acute myeloid leukemia who underwent allogeneic bone marrow transplantation and thereafter developed rhabdomyolysis and Candida parapsilosis fungemia almost at the same time. Following treatment for C. parapsilosis, the transaminase and CK levels both satisfactorily decreased. This case illustrates that C. parapsilosis infection may be a causative agent of rhabdomyolysis in immunocompromised patients.

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Section: Discussionsupporting

confidence: 53%

Rhabdomyolysis Caused by <i>Candida parapsilosis</i> in a Patient with Acute Myeloid Leukemia after Bone Marrow Transplantation

et al. 2015

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“…Hypophosphatemia and hypokalemia are well known causes of rhabdomyolysis, 29,30 and the mild elevation of creatine phosphokinase concentration in 12 (67%) of 18 episodes may be related to the low serum P and K levels.…”

Section: Commentmentioning

confidence: 99%

Clinical and Metabolic Features of Thyrotoxic Periodic Paralysis in 24 Episodes

Manoukian¹,

Foote²,

Crapo³

1999

Arch Intern Med

220

183

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“…Hypophosphatemia, the predominant feature of the RS, may lead to impaired skeletal muscle function, weakness, myopathy, and even rhabdomyolysis [11] . Cardiomyopathy may be an associated complication [12] .…”

mentioning

confidence: 99%

Mortality after Nasogastric Tube Feeding Initiation in Long-Term Care Elderly with Oropharyngeal Dysphagia – The Contribution of Refeeding Syndrome

et al. 2009

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Background: The refeeding syndrome (RS) is an underappreciated but clinically important entity characterized by acute electrolyte abnormalities, mainly hypophosphatemia, fluid retention and dysfunction of various organs and systems, which can result in significant morbidity and occasionally death. Objective: To examine the incidence of death cases and death causes following nasogastric tube (NGT) feeding initiation in frail elderly with particular reference to RS. Methods: Forty patients with feeding problems for at least 72 h before restarting of alimentation by NGT were included. Excluded were those in any critical clinical situation. Clinical parameters and nutritional assessment were recorded before and after refeeding. Blood samples were taken before, daily for the first 3 days and 1 week after refeeding initiation. Results: During the 1st week of refeeding, 9 patients (22.5%) died and within 1 month 10 more, summing to 47.5%. Most deaths were due to infectious causes [15 out of 19, (79%)]; some were due to no obvious reason [4 out of 19, (21%)]. Significant electrolyte changes were observed in the 2–3 days following refeeding. Significant were the decreases in phosphorus and elevations in potassium and lymphocytes (day 7). We found no correlations between the severity of decreases in levels of phosphorus and mortality. Conclusions: Mortality after NGT feeding initiation was high, mainly due to infectious complications. However, in a considerable number of patients hypophosphatemia was noted, suggesting that RS could be a contributory factor of mortality. Since this is a treatable condition, more attention should be paid to detecting and coping with this problem.

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Prevalence and predictors of rhabdomyolysis in patients with hypophosphatemia

Cited by 109 publications

References 12 publications

Rhabdomyolysis Caused by <i>Candida parapsilosis</i> in a Patient with Acute Myeloid Leukemia after Bone Marrow Transplantation

Rhabdomyolysis Caused by <i>Candida parapsilosis</i> in a Patient with Acute Myeloid Leukemia after Bone Marrow Transplantation

Clinical and Metabolic Features of Thyrotoxic Periodic Paralysis in 24 Episodes

Mortality after Nasogastric Tube Feeding Initiation in Long-Term Care Elderly with Oropharyngeal Dysphagia – The Contribution of Refeeding Syndrome

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