Background: Human health is largely affected by self-medication in both ways, adversely and favorably, as evidenced by the COVID-19 pandemic. The fear of spreading novel coronavirus disease (COVID-19) from health workers and hospital environments has led many Bangladeshi people to practice self-medicate for as the preventive strategy against this disease. Consequently, this practice entails an improper and injudicious use of medicine to cure self-recognized symptoms. To date, the COVID-19 has no effective treatment. The lack of a cure for COVID-19 and the continual progression of the diseases in educational settings induce a substantial population to practice self-medication. Therefore, a study of self-medication practices is necessary for the framework of the pandemic. This study aimed to estimate the prevalence and factors associated with selfmedication to prevent or manage future COVID-19 infections among recovered COVID-19 patients. Methods: This cross-sectional study was conducted since September 2020 to February 2021 using an e-survey along with 360 participants (>18 years). Data were collected using a pre-tested self-reported questionnaire. Descriptive statistics and correlations analysis were performed in the study. Results: Among 360 (male 69.7% and female 30.3%) participants, the prevalence of selfmedication is 11%, and monthly family income, residence, education, occupation, and previous history of SM are the associated factors. Among the participants, 29.7% use antibiotics, and 30% use herbal products/drugs as medication. Conclusion: The present study found SMP is moderately prevalent among COVID-19 recovered patients. To minimize the rate of SMP, adequate health careaccess systems and public education should be introduced, and media and community should be engaged in rational use of medication.