Prevalence and Presentation of Lactose Intolerance and Effects on Dairy Product Intake in Healthy Subjects and Patients With Irritable Bowel Syndrome

Yang, Jianfeng; Deng, Yanyong; Chu, Huimin; Cong, Yanqun; Zhao, Jimeng; Pohl, Daniel; Misselwitz, Benjamin; Fried, Michael; Dai, Ning; Fox, Mark

doi:10.1016/j.cgh.2012.11.034

Cited by 128 publications

(159 citation statements)

References 25 publications

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“…Those patients with a higher peak in breath hydrogen were no more likely to report symptoms with inulin or fructose, in agreement with other studies suggesting that the utility of a breath test to predict response to dietary fructose exclusion is limited 33,34 . An alternative hypothesis would be that, as has been shown with lactose malabsorption 35 , the patients with symptoms had a lower sensory threshold for reporting.…”

Section: Discussionmentioning

confidence: 99%

Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome

et al. 2017

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“…The search for possible mechanisms is likely to be further complicated by evidence that patients may report symptoms of intolerance in the absence of changes in clinical indices (e.g. breath hydrogen) (33,34) . Further, while serological and histological markers have been identified that may be able to distinguish between non-coeliac wheat sensitivity, IBS and coeliac disease, wheat sensitivity is a heterogeneous condition comprising various subgroups displaying different clinical characteristics (15) .…”

Section: Symptoms and Mechanismsmentioning

confidence: 99%

Motivations for avoiding wheat consumption in Australia: results from a population survey

Golley

Corsini

Topping

et al. 2014

Public Health Nutr.

126

105

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Objective: To assess the prevalence of and explanations for wheat avoidance, including reported symptoms, diagnoses and information sources influencing the decision to avoid wheat, and to investigate potential psychological predictors of this behaviour. Design: Cross-sectional population survey. Setting: The study was conducted in Australia, using a nationwide postal omnibus survey. Subjects: Adults aged 18 years and over (n 1184; 52·9 % female) selected at random from the Australian Electoral Roll. Results: With cases of stated and suspected coeliac disease (1·2 %) excluded, 7·3 % of the sample reported adverse physiological effects, predominantly gastrointestinal, that they associated with wheat consumption. Few among this group (5·7 %) claimed a formally diagnosed intolerance or allergy requiring avoidance of wheatbased foods. Symptomatic wheat avoidance was highly correlated with dairy avoidance and predicted by gender (female), lesser receptiveness to conventional medicine and greater receptiveness to complementary medicine, but not by neuroticism, reasoning style or tendency to worry about illness. Conclusions:The data indicate that many adult Australians are consciously avoiding consumption of wheat foods, predominantly without any formal diagnosis. Reported symptoms suggest a physiological but not allergenic basis to this behaviour. Questions to be answered concern whether symptoms are attributed correctly to wheat, the agents (wheat components, dietary factors or additives) and physiological mechanism(s) involved, the nutritional adequacy of avoiders' diets, and the clinical and psychosocial processes that lead a substantial number of adults to avoid consuming wheat (or any other dietary factor) apparently independently of a medical diagnosis.

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“…A recent National Institutes of Health (NIH) conference defined "lactose intolerance as the onset of GI symptoms following a blinded, single-dose challenge of ingested lactose by an individual with lactose malabsorption, which are not observed when the person ingests an indistinguishable placebo." 73 The risk of lactose intolerance is related to the dose of lactose ingested and intestinal gas production and is increased in patients with IBS-D. 74 Although it is not easy to exclude lactose intolerance in daily clinical practice, it should not be included in IBS.…”

Section: Race/geographic Areamentioning

confidence: 99%

Epidemiology of Functional Gastrointestinal Disorders in Japan and in the World

Oshima

Miwa

2015

J Neurogastroenterol Motil

138

130

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Functional gastrointestinal disorders (FGIDs), represented by functional dyspepsia (FD) and irritable bowel syndrome (IBS), are a group of disorders that include variable combinations of chronic or recurrent gastrointestinal symptoms not explained by structural or biochemical abnormalities. FGIDs account for a significant percentage of patients seen in primary care settings with abdominal symptoms. Although the definition of FGIDs can easily affect the prevalence, the prevalences of dyspepsia/FD and IBS diagnosed by the Rome III criteria in the general population are 5.3-20.4% and 1.1-29.2%, respectively. Recent reports of FD and IBS defined by the Rome III criteria indicated a female predominance. Regarding the subtype prevalence of FD, postprandial distress syndrome was more prevalent than epigastric pain syndrome (5.6-13.9% vs 0.9-9.5%). The subtype prevalence of IBS is characterized by male predominance for IBS with diarrhea and female predominance for IBS with constipation. Factors affecting the development of FGIDs such as epidemiological factors including genetic and environmental factors, are important. Gene polymorphisms are involved in the development of FGIDs. The prevalence differs among races and geographic areas. Foods may affect the development of FGIDs, but the causal relationships between food and FGIDs are not conclusive. The symptoms often regress and appear in the course of these entities. Building a favorable patient-doctor relationship is effective for controlling symptoms of FGIDs. Physicians should explain that FGIDs are highly prevalent conditions, impair the patients' quality of life even without evident underlying organic causes and are not life-threatening conditions to ensure patients' understanding.

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Prevalence and Presentation of Lactose Intolerance and Effects on Dairy Product Intake in Healthy Subjects and Patients With Irritable Bowel Syndrome

Cited by 128 publications

References 25 publications

Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome

Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome

Motivations for avoiding wheat consumption in Australia: results from a population survey

Epidemiology of Functional Gastrointestinal Disorders in Japan and in the World

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