Prevalence and presentation of Lassa fever in Nigerian children

Akpede, George O.; Odike, Angela; Okokhere, Peter O; Olomu, Sylvia C.; Asogun, Danny; Happi, Christian; Günther, Stephan

doi:10.1016/j.ijid.2010.02.465

Cited by 4 publications

(7 citation statements)

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“…Three articles presented studies set in more than one country [48, 114, 121]. Five were conference abstracts [33–36, 41] and two ongoing cohort studies registered by the US Army, evaluating effectiveness and safety of ribavirin, expected to be completed in 2018 and 2019 [121, 122]. Table 3 presents an overview of the study setting, populations, objectives, and interventions identified for the studies in each clinical domain.…”

Section: Resultsmentioning

confidence: 99%

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A rapid research needs appraisal methodology to identify evidence gaps to inform clinical research priorities in response to outbreaks—results from the Lassa fever pilot

Sigfrid

Moore

Salam

et al. 2019

BMC Med

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Background Infectious disease epidemics are a constant threat, and while we can strengthen preparedness in advance, inevitably, we will sometimes be caught unaware by novel outbreaks. To address the challenge of rapidly identifying clinical research priorities in those circumstances, we developed and piloted a protocol for carrying out a systematic, rapid research needs appraisal (RRNA) of existing evidence within 5 days in response to outbreaks globally, with the aim to inform clinical research prioritization. Methods The protocol was derived from rapid review methodologies and optimized through effective use of pre-defined templates and global time zones. It was piloted using a Lassa fever (LF) outbreak scenario. Databases were searched from 1969 to July 2017. Systematic reviewers based in Canada, the UK, and the Philippines screened and extracted data using a systematic review software. The pilot was evaluated through internal analysis and by comparing the research priorities identified from the data, with those identified by an external LF expert panel. Results The RRNA pilot was completed within 5 days. To accommodate the high number of articles identified, data extraction was prioritized by study design and year, and the clinical research prioritization done post-day 5. Of 118 potentially eligible articles, 52 met the data extraction criteria, of which 46 were extracted within the 5-day time frame. The RRNA team identified 19 clinical research priorities; the expert panel independently identified 21, of which 11 priorities overlapped. Each method identified a unique set of priorities, showing that combining both methods for clinical research prioritization is more robust than using either method alone. Conclusions This pilot study shows that it is feasible to carry out a systematic RRNA within 5 days in response to a (re-) emerging outbreak to identify gaps in existing evidence, as long as sufficient resources are identified, and reviewers are experienced and trained in advance. Use of an online systematic review software and global time zones effectively optimized resources. Another 3 to 5 days are recommended for review of the extracted data and to formulate clinical research priorities. The RRNA can be used for a “Disease X” scenario and should optimally be combined with an expert panel to ensure breadth and depth of coverage of clinical research priorities. Electronic supplementary material The online version of this article (10.1186/s12916-019-1338-1) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

“…Most of the studies were set in West Africa. Fourteen studies were set in Nigeria [18, 19, 21, 22, 24, 26, 33, 34, 36, 39, 41, 42, 48, 127], seven in Sierra Leone [20, 25, 27, 40, 43, 45, 48], three in Liberia [23, 46, 48], three in Mali [32, 47, 48], and one in the USA [48]. One study was set in multiple locations [48].…”

Section: Resultsmentioning

confidence: 99%

A rapid research needs appraisal methodology to identify evidence gaps to inform clinical research priorities in response to outbreaks—results from the Lassa fever pilot

Sigfrid

Moore

Salam

et al. 2019

BMC Med

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…It is Endo-endemic in most states in Nigeria (Akpede et al, 2009;Ehichioya et al, 2012) with Edo state accounting for a high number of cases (Reliefweb, 2016). It is the cause in 1.6% of all children admissions at the apex health institute in Edo central senatorial district (Akpede et al, 2009). The early symptoms of the disease are similar to those found in other common febrile illnesses in our environment (McCormick et al, 1987;Richmond et al, 2003;Month et al, 1975), which poses serious challenges to the early diagnosis and treatment of Lassa fever cases and resulting in case fatalities of 50-90% (Richmond et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…This results in many false negatives in the early phase because in most cases, bleeding does not occur in the early stages of the disease (Akpede et al, 2009). This makes an appraisal of the current IDSR and the development of an appropriate case definition with higher degree of certainty necessary in order to reduce the public health impact of the disease.…”

Section: Introductionmentioning

confidence: 99%

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