Prevalence and prognostic significance of gamma-glutamyltransferase (GGT) in chronic heart failure

Eberl, C.; Achrainer, H.; Doerler, J.; Ulmer, Hanno; Pachinger, Otmar; Frick, M.; Poelz, G.

doi:10.1016/s1567-4215(08)60240-4

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“…Gamma-glutamyltransferase (GGT) is an important type of active enzyme in cells and plays a key role in the gamma-glutamyl cycle. , The highest concentration of GGT in the body is found in the liver and the changes in its expression level can be used to evaluate various causes of liver damage or diseases, such as liver cancer and viral hepatitis. , However, the expression of GGT in blood, kidneys, or other parts of the body may be related to other diseases, , like acute coronary syndrome . Therefore, the localization and detection of GGT in the liver (or HepG2 cells) is helpful for the early analysis of hepatoma. , …”

Section: Introductionmentioning

confidence: 99%

Simultaneous Targeted Analysis of GGT and Its H-Type mRNA in HepG2 Cells Based on Degradable Silicon Nanomaterials

Gao

et al. 2021

Anal. Chem.

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Most important physiological processes in live cells are usually maintained by the interaction of multiple related biomolecules; the multi-target simultaneous analysis of these related molecules can better reflect the dynamic changes of their biological regulatory processes, providing more comprehensive information for diseases diagnosis and research. Herein, we have constructed the degradable multifunctional silica nanomaterials from the prepared degradable organic silicon source and further established degradable composite nanoprobes (DCNPs). The low toxicity of DCNPs could reduce the impact on normal physiological processes in cells and achieve the needs of living cell analysis applications; by the loading of the gamma-glutamyltransferase (GGT) activityidentification probe (Cy-GGT) and surface nucleic acid-recognizing molecular beacon (hairpin) modification, the DCNP realized the simultaneous image analysis of GGT and its related H-type mutated GGT mRNA (H-mRNA) in HepG2 cells and their quantitative detection in vitro. Compared with the traditional multi-target analysis strategy, the lack of targets' physiological mechanism connection was improved, and the combined application of small molecular probes and nucleic acid analysis structures was realized under the control of the cross-influence. This strategy is expected to provide a new direction for the design of multi-target analysis in live cells and provide more accurate analytical tools for clinical research and cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Simultaneous Targeted Analysis of GGT and Its H-Type mRNA in HepG2 Cells Based on Degradable Silicon Nanomaterials

Gao

et al. 2021

Anal. Chem.

View full text Add to dashboard Cite

show abstract

Prevalence and prognostic significance of gamma-glutamyltransferase (GGT) in chronic heart failure

Cited by 1 publication

References 0 publications

Simultaneous Targeted Analysis of GGT and Its H-Type mRNA in HepG2 Cells Based on Degradable Silicon Nanomaterials

Simultaneous Targeted Analysis of GGT and Its H-Type mRNA in HepG2 Cells Based on Degradable Silicon Nanomaterials

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