Prevalence and Prognostic Significance of Left Ventricular Noncompaction in Patients Referred for Cardiac Magnetic Resonance Imaging

Ivanov, Alexander; Dabiesingh, Devindra S.; Bhumireddy, Geetha P.; Mohamed, Ambreen; Asfour, Ahmed; Briggs, William M.; Ho, Jean; Khan, Saadat; Grossman, Alexandra; Klem, Igor; Sacchi, Terrence J.; Heitner, John F.

doi:10.1161/circimaging.117.006174

Cited by 94 publications

(54 citation statements)

References 30 publications

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“…Similar findings have been reported in small studies of asymptomatic athletes and healthy pregnant women (12)(13)(14). These findings have been replicated in single center studies of symptomatic individuals and those with known structural heart disease (15,16). Further, a multicenter study of individuals diagnosed with LVNC reports better than expected outcomes with no prognostic impact of LV trabeculation beyond known parameters such as left ventricular ejection fraction (LVEF) (17).…”

Section: Introductionsupporting

confidence: 77%

Left Ventricular Hypertrabeculation Is Not Associated With Cardiovascular Morbity or Mortality: Insights From the Eurocmr Registry

Zemrak

Raisi‐Estabragh

Khanji

et al. 2020

Front. Cardiovasc. Med.

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Aim: Left ventricular non-compaction (LVNC) is perceived as a rare high-risk cardiomyopathy characterized by excess left ventricular (LV) trabeculation. However, there is increasing evidence contesting the clinical significance of LV hyper-trabeculation and the existence of LVNC as a distinct cardiomyopathy. The aim of this study is to assess the association of LV trabeculation extent with cardiovascular morbidity and all-cause mortality in patients undergoing clinical cardiac magnetic resonance (CMR) scans across 57 European centers from the EuroCMR registry. Methods and Results: We studied 822 randomly selected cases from the EuroCMR registry. Image acquisition was according to international guidelines. We manually segmented images for LV chamber quantification and measurement of LV trabeculation (as per Petersen criteria). We report the association between LV trabeculation extent and important cardiovascular morbidities (stroke, atrial fibrillation, heart failure) and all-cause mortality prospectively recorded over 404 ± 82 days of follow-up. Maximal non-compaction to compaction ratio (NC/C) was mean (standard deviation) 1.81 ± 0.67, from these, 17% were above the threshold for hyper-trabeculation (NC/C > 2.3). LV trabeculation extent was not associated with increased risk of the defined outcomes (morbidities, mortality, LV CMR indices) in the whole cohort, or in sub-analyses of individuals without ischaemic heart disease, or those with NC/C > 2.3. Zemrak et al. LV Hypertrabeculation and Cardiovascular Outcomes Conclusion: Among 882 patients undergoing clinical CMR, excess LV trabeculation was not associated with a range of important cardiovascular morbidities or all-cause mortality over ∼12 months of prospective follow-up. These findings suggest that LV hyper-trabeculation alone is not an indicator for worse cardiovascular prognosis.

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Section: Introductionsupporting

confidence: 77%

Left Ventricular Hypertrabeculation Is Not Associated With Cardiovascular Morbity or Mortality: Insights From the Eurocmr Registry

Zemrak

Raisi‐Estabragh

Khanji

et al. 2020

Front. Cardiovasc. Med.

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“…Sol ventrikül nonkompaksiyonu tanısı konulduğunda, tromboembolizm riski bulunan hastalara antikoagülan verilmesi [8,9], yaşamı tehdit eden aritmileri bulunan hastalara ise implante edilebilir bir kardiyoverter defibrilatörün (ICD) profilaktik yerleştirilmesi ölümcül komplikasyonları önleyebilir [10]. Bizim olgumuzda tromboemboli riski bulunmadığından ve aritmisi olmadığından hasta takibe alınmıştır.…”

Section: Discussionunclassified

Sol ventrikül nonkompaksiyonu: Manyetik rezonans görüntüleme bulguları

Hasbey

Yavaş

Kılıç

et al. 2019

Pamukkale Medical Journal

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ÖzetSol ventrikül nonkompaksiyonu (SVNC), sol ventrikül miyokardının nadir görülen morfo-lojik bir anomalisidir. Sol ventrikül boşluğu ile komşu derin intertrabeküler oyuklar ile tra-beküle halde miyokard ile karakterizedir. Sol ventrikülün apikal ve midventriküler seg-mentleri en sık etkilenen kesimlerdir. SVNC'li hastalar asemptomatik olabileceği gibi bu hastalarda göğüs ağrısı, kalp yetmezliği ve aritmiler görülebilir. İleri hastalık aşamalarında, çoğu hastada kalp yetmezliği gelişir. Ek olarak, SVNC embolik olaylara, aritmilere ve ani ölüm gibi komplikasyonlara yol açabilir. Bu komplikasyonlar, yüksek riskli hastaların erken tanı ve zamanında tedavisi ile önlenebilir. Biz burada asemptomatik bir SVNC olgusu sunarak SVNC'nin manyetik rezonans görüntüleme bulgularını ortaya koymayı amaçladık. Anahtar Kelimeler: Kardiyak MR,kardiyomiyopati,kalp yetersizliği,miyokard trabekülasyonları,ani ölüm. Yavaş HG, Hasbey İ, Kılıç İD, Ufuk F. Sol ventrikül nonkompaksiyonu: Manyetik rezonans görüntüleme bulguları. Pam Tıp Derg 2019;12:343-346. AbstractLeft ventricular noncompaction (LVNC) is a rare morphological abnormality of the left ventricular myocardium. It is characterized by trabeculated myocardium with adjacent deep intertrabecular recesses communicating with the left ventricular cavity. Most com-monly, the apical and midventricular segments of left ventricle are affected. Patients with LVNC may have no symptoms or present with chest pain, heart failure, and arrhythmias. In the advanced disease stages, heart failure is present in most of the patients. In additi-on, LVNC can lead to fatal complications, such as embolic events, arrhythmias, and sud-den death. These complications can be avoided with early diagnosis and timely treat-ment of patients at high risk. Herein, we presented an asymptomatic case of LVNC and our aim was to demonstrate the magnetic resonance imaging findings of LVNC.

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“…It is currently unclear whether the identification of LVNC in the presence of other cardiac or neuromuscular phenotypes signifies a worse prognosis. 13 , 14 …”

Section: Discussionmentioning

confidence: 99%

Holt-Oram syndrome in two families diagnosed with left ventricular noncompaction and conduction disease

Ross

Bagnall

Yeates

et al. 2018

HeartRhythm Case Reports

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Prevalence and Prognostic Significance of Left Ventricular Noncompaction in Patients Referred for Cardiac Magnetic Resonance Imaging

Cited by 94 publications

References 30 publications

Left Ventricular Hypertrabeculation Is Not Associated With Cardiovascular Morbity or Mortality: Insights From the Eurocmr Registry

Left Ventricular Hypertrabeculation Is Not Associated With Cardiovascular Morbity or Mortality: Insights From the Eurocmr Registry

Sol ventrikül nonkompaksiyonu: Manyetik rezonans görüntüleme bulguları

Holt-Oram syndrome in two families diagnosed with left ventricular noncompaction and conduction disease

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