Prevalence and Prognostic Value of Depression and Anxiety in Patients with Diabetic Foot Ulcers and Possibilities of their Treatment

Udovichenko, Oleg Viktorovich; Maximova, Nadezhda; Amosova, M.; Yunilaynen, O A; Берсенева, Е А; Старостина, Е. Г.

doi:10.2174/1573399812666160523143354

Cited by 24 publications

(28 citation statements)

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“…The study data indicate that 39.6% have depression and this figure is comparable to the 39% reported by OlegaV [ 21 ], higher than the 32.2% and 34.2% reported among patients with diabetic foot [ 23 ], but higher than the 22% reported by Bala et al [ 24 ]. In their study, Carrington et al [ 25 ] had noted that patients with diabetic foot reported more depressive symptoms than patients with diabetes alone.…”

Section: Discussionsupporting

confidence: 69%

“…The instrument has been validated for use in clinical practice and found to have adequate convergent and discriminant validity [ 20 ]. The internal consistency reliability of the PHQ-9 was excellent, with a Cronbach α of 0.89, in the primary care setting [ 21 ]. For depression assessment, the Patient Health Questionnaire- 9 (PHQ-9) is a valid and reliable instrument.…”

Section: Methodsmentioning

confidence: 99%

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Anxiety and Depression Among Adult Patients With Diabetic Foot: Prevalence and Associated Factors

Ahmad¹,

Abujbara²,

Jaddou

et al. 2018

J Clin Med Res

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BackgroundDiabetic foot is a frequent complication of diabetes mellitus with subsequent disturbances in the daily life of the patients. The co-existence of depression and anxiety among diabetic foot patients is a common phenomenon and the role of each of them in perpetuating the other is highlighted in the literature. Our study aimed to determine the prevalence rates of anxiety and depression, and to examine the associated risk factors among diabetic foot patients.MethodsThis is a cross-sectional study. A total of 260 diabetic foot patients in the Diabetic Foot Clinic at the National Center for Diabetes, Endocrinology and Genetics (NCDEG), Amman, Jordan, participated in the study. Sociodemographic and health data were gathered through review of medical charts and a structured questionnaire. Depression and anxiety status were also assessed. The Generalized Anxiety Disorder Scale (GAD-7) was used to screen for anxiety and the Patient Health Questionnaire (PHQ-9) was used to screen for depression. A cutoff of ≥ 10 was used for each scale to identify those who tested positive for anxiety and depression.ResultsPrevalence rate of anxiety was 37.7% and that of depression was 39.6%. Multiple logistic regression analysis showed that anxiety is positively associated with duration of diabetes of < 10 years (P = 0.01), with ≥ three comorbid diseases (P = 0.00), and HbA1c level of > 7% (P = 0.03). Multiple logistic regression analysis also showed that depression is positively associated with patients of < 50 years of age (P = 0.03), females (P = 0.01), current smokers (P = 0.01), patients with foot ulcer duration ≥ 7 months (P = 0.00), with ≥ three comorbid diseases (P = 0.00) than their counterparts.ConclusionsAnxiety and depression are widely prevalent among diabetic foot patients. Mental health status of those patients gets even worse among those suffering other comorbid diseases, which was a finding that requires special attention in the management of patients with diabetic foot.

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Section: Discussionsupporting

confidence: 69%

Section: Methodsmentioning

confidence: 99%

Anxiety and Depression Among Adult Patients With Diabetic Foot: Prevalence and Associated Factors

Ahmad¹,

Abujbara²,

Jaddou

et al. 2018

J Clin Med Res

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“…Udovichenko et al 39 analogously found about 39% patients with depression and 36% with anxiety in a population of patients with diabetic ulcers. Depression and anxiety were found more often in females than in males (48% and 46% vs 27% and 25%, respectively) in the general population.…”

Section: 37mentioning

confidence: 84%

Depression and quality of life in patients with chronic wounds: ways to measure their influence and their effect on daily life

Renner¹,

Erfurt‐Berge²

2017

CWCMR

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Depression is a very common comorbidity in patients with chronic wounds. At least 30% of those patients suffer from depressive symptoms or anxiety. To measure impairment on daily life, different quality of life (QoL) questionnaires can be used as well as specialized questionnaires to evaluate different levels of depression. In this review, we present some of the current measurement tools and effects of depression on QoL. Depression is often associated with wound duration, odor of wounds, and furthermore with pain and immobility. On the other hand, depression might reduce wound healing itself via psychoimmunological effects. QoL, in general, is reduced in patients with chronic wounds, but especially in the case of pain, immobility and older age, and sometimes independent to wound status (healed or active). Treating medical and health care personnel should establish depression and QoL questionnaires in daily practice and should consider the psychological health of their patients as part of their treatment.

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“…Depression, anxiety, and impaired cognition are associated with chronic wounds of multiple etiologies, including diabetic foot ulcers (DFU), venous ulcers, arterial ulcers, pressure ulcers, surgical wounds, and other traumatic wounds . A cross‐sectional large‐scale multicenter study demonstrated that the odds of depression among patients with leg ulcers were significantly higher than for patients with other skin diseases including psoriasis, atopic dermatitis, and nonmelanoma skin cancer .…”

Section: Introductionmentioning

confidence: 99%

“…Another cross‐sectional study of chronic venous ulcer patients found at least a 30% prevalence of depression and/or anxiety . Additionally, approximately 40% of DFU patients exhibit cognitive dysfunction and depression, as well as lower cognitive scores marked by decreased memorization and concentration ability, increased learning difficulties, delayed cognitive and psychomotor responses, and decreased verbal fluency when compared to age‐matched diabetic patients without chronic ulcers . Interestingly, diabetic patients who suffer from depression are twice as likely to develop a chronic foot ulcer, and depression is also a risk factor for infection in the chronic wound .…”

Section: Introductionmentioning

confidence: 99%

Microbiome‐skin‐brain axis: A novel paradigm for cutaneous wounds

Hadian

Fregoso

Nguyen

et al. 2020

Wound Repair Regeneration

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Chronic wounds cause a significant burden on society financially, medically, and psychologically. Unfortunately, patients with nonhealing wounds often suffer from comorbidities that further compound their disability. Given the high rate of depressive symptoms experienced by patients with chronic wounds, further studies are needed to investigate the potentially linked pathophysiological changes in wounds and depression in order to improve patient care. The English literature on wound healing, inflammatory and microbial changes in chronic wounds and depression, and antiinflammatory and probiotic therapy was reviewed on PubMed. Chronic wound conditions and depression were demonstrated to share common pathologic features of dysregulated inflammation and altered microbiome, indicating a possible relationship. Furthermore, alternative treatment strategies such as immune-targeted and probiotic therapy showed promising potential by addressing both pathophysiological pathways. However, many existing studies are limited to a small study population, a cross-sectional design that does not establish temporality, or a wide range of confounding variables in the context of a highly complex and multifactorial disease process. Therefore, additional preclinical studies in suitable wound models, as well as larger clinical cohort studies and trials are necessary to elucidate the relationship between wound microbiome, healing, and depression, and ultimately guide the most effective therapeutic and management plan for chronic wound patients.

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Prevalence and Prognostic Value of Depression and Anxiety in Patients with Diabetic Foot Ulcers and Possibilities of their Treatment

Cited by 24 publications

References 0 publications

Anxiety and Depression Among Adult Patients With Diabetic Foot: Prevalence and Associated Factors

Anxiety and Depression Among Adult Patients With Diabetic Foot: Prevalence and Associated Factors

Depression and quality of life in patients with chronic wounds: ways to measure their influence and their effect on daily life

Microbiome‐skin‐brain axis: A novel paradigm for cutaneous wounds

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