Prevalence and risk factor for long COVID in children and adolescents: A meta-analysis and systematic review

Zheng, Yongbo; Zeng, Na; Yuan, Kai; Tian, Shan-Shan; Yang, Ying-Bo; Gao, Nan; Chen, Xuan; Zhang, An-Yi; Kondratiuk, Alexandra L; Shi, Peipei; Zhang, Fang; Sun, Jie; Yue, Jing-Li; Lin, Xiao; Shi, Le; Lalvani, Ajit; Shi, Jie; Bao, Yanping; Lü, Lin

doi:10.1016/j.jiph.2023.03.005

Cited by 80 publications

(62 citation statements)

References 72 publications

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“…Psychiatric symptoms in the chronic phase are diverse and difficult for both patients and practitioners to identify as sequelae of COVID-19. Alternatively, it is possible that most people with COVID-19 experienced spontaneous remission within approximately one year [35, 36] and it might have been difficult to gather participants for clinical trials. Subsequently, regional diversity was found.…”

Section: Discussionmentioning

confidence: 99%

Psychotherapies and Psychological Support for Individuals Facing Psychological Distress during the COVID-19 Pandemic: A Scoping Review

Yagihashi,

Sakuma,

Murakami

2023

Preprint

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In this scoping review, we investigated psychotherapies and psychological support provided during the coronavirus disease 2019 (COVID-19) pandemic to clarify its recipients and the methods employed. We used Scopus and PubMed as the search engines on October 18, 2022, employing specific search terms (″COVID* ″ AND (″Psychotherap*″ OR ″psychological support*″) AND ″psychological distress*″). The initial search yielded 153 articles, of which 18 met the eligibility criteria after two rounds of screening. The distribution of participants ranged from the general population to patients with COVID-19 and those who had recovered. However, no studies of patients with post-COVID-19 sequelae were found. The distribution of the types of psychotherapies and psychological support varied and the use of new technology was suggested. Online interventions comprised the majority of the means of psychotherapies and psychological support. This study suggests that psychotherapies and psychological support during the COVID-19 pandemic were influenced by the social situation.

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Section: Discussionmentioning

confidence: 99%

Psychotherapies and Psychological Support for Individuals Facing Psychological Distress during the COVID-19 Pandemic: A Scoping Review

Yagihashi,

Sakuma,

Murakami

2023

Preprint

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“…The major neurological manifestations during acute COVID-19 disease in children include headaches, dizziness, and anosmia [49 ▪▪ ,50]. Headache is a common symptom of COVID-19 in children [3,49 ▪▪ ,50–54,55 ▪ ]. Headache, myalgia, and fatigue are the predominant nonspecific neurological manifestations of COVID-19 in children and occur together in 16.7% of cases [54].…”

Section: Epidemiology Of Covid-19 Related Headachesmentioning

confidence: 99%

“…Whilst neurological issues during the acute phase of infection do not generally lead to hospitalization in children, seizures, dizziness, and headache might be severe enough in some to warrant hospital care [50]. Headache alongside fatigue and dyspnoea is also a common symptom of long COVID in children with prevalence rates of up to 23% [4,55 ▪ ,56 ▪▪ ].…”

Section: Epidemiology Of Covid-19 Related Headachesmentioning

confidence: 99%

COVID-19 related headaches: epidemiology, pathophysiology, impacts, and management

Aiyegbusi

2023

Current Opinion in Neurology

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Purpose of review This is an expert overview of the recent literature on the nature, epidemiology, pathophysiology, impact, and management of COVID-19 related headache, in the acute phase of infection and in post-COVID-19 syndrome. Recent findings Headache is one of the commonest symptoms of COVID-19 during acute infection and it is often experienced by individuals who go on to develop long COVID. There is a higher prevalence of headache in individuals with long COVID who contracted the Delta variant than in those who were infected with the Wuhan or Alpha variants. Headaches related to COVID-19 infection are commoner and may be more intense in women. There are indications that presence of headache might indicate a more benign COVID-19 infection and a better chance of survival. However, the impact of COVID-19 related headache could be substantial leading to poor quality of life in individuals affected. Headache that changes in its nature in terms of frequency and severity should be investigated to exclude cerebrovascular complications. There are promising new therapies for its treatment, but further research is needed. Summary The findings of this review can promote a better understanding of COVID-19 related headache and guide clinicians in the management of patients.

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“…149 Approximately 25% of pediatric COVID survivors have suffered multisystem long infection, even 12 months after the onset of infection. 150 A research study involving 510 pediatric COVID cases from different European countries has reported that 30%−50% of COVID survivors suffered multisystem long infection after 4−5 months from the onset of COVID-19. 151 The symptoms persisted for 8 months on average, with periods of obvious remission, followed by exacerbations in 50% of the cases, and merely 10% of the cases could return to their normal levels of physical activity.…”

Section: Viral Persistence and Prevalence Of Long Covid In Childrenmentioning

confidence: 99%

Intrinsic factors behind long COVID: III. Persistence of SARS‐CoV‐2 and its components

El‐Baky,

Amara,

Uversky

et al. 2023

J of Cellular Biochemistry

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Considerable research has been done in investigating SARS‐CoV‐2 infection, its characteristics, and host immune response. However, debate is still ongoing over the emergence of post‐acute sequelae of SARS‐CoV‐2 infection (PASC). A multitude of long‐lasting symptoms have been reported several weeks after the primary acute SARS‐CoV‐2 infection that resemble several other viral infections. Thousands of research articles have described various post‐COVID‐19 conditions. Yet, the evidence around these ongoing health problems, the reasons behind them, and their molecular underpinnings are scarce. These persistent symptoms are also known as long COVID‐19. The persistence of SARS‐CoV‐2 and/or its components in host tissues can lead to long COVID. For example, the presence of viral nucleocapsid protein and RNA was detected in the skin, appendix, and breast tissues of some long COVID patients. The persistence of viral RNA was reported in multiple anatomic sites, including non‐respiratory tissues such as the adrenal gland, ocular tissue, small intestine, lymph nodes, myocardium, and sciatic nerve. Distinctive viral spike sequence variants were also found in non‐respiratory tissues. Interestingly, prolonged detection of viral subgenomic RNA was observed across all tissues, sometimes in multiple tissues of the same patient, which likely reflects recent but defective viral replication. Moreover, the persistence of SARS‐CoV‐2 RNA was noticed throughout the brain at autopsy, as late as 230 days following symptom onset among unvaccinated patients who died of severe infection. Here, we review the persistence of SARS‐CoV‐2 and its components as an intrinsic factor behind long COVID. We also highlight the immunological consequences of this viral persistence.

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Prevalence and risk factor for long COVID in children and adolescents: A meta-analysis and systematic review

Cited by 80 publications

References 72 publications

Psychotherapies and Psychological Support for Individuals Facing Psychological Distress during the COVID-19 Pandemic: A Scoping Review

Psychotherapies and Psychological Support for Individuals Facing Psychological Distress during the COVID-19 Pandemic: A Scoping Review

COVID-19 related headaches: epidemiology, pathophysiology, impacts, and management

Intrinsic factors behind long COVID: III. Persistence of SARS‐CoV‐2 and its components

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