Prevalence and Risk Factor of Erosive Esophagitis Observed in Korean National Cancer Screening Program

Kim, Beom Jin; Cheon, Won Seok; Oh, Hyoung‐Chul; Kim, Jeong Wook; Park, Jung Duck; Kim, Jae Gwan

doi:10.3346/jkms.2011.26.5.642

Cited by 18 publications

(18 citation statements)

References 23 publications

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“…In this study, the prevalence of EE was 8.8 %, which is similar to the prevalence rates of 6.7, 7.9, and 7.6 % in previous Korean studies (Kim et al 2011a , b ; Shim et al 2009 ; Lee et al 2011 ) and 6.4 % in a Chinese study (Zou et al 2011 ), but lower than the prevalence rates of 15.5 and 11.8 % in Western populations (Ronkainen et al 2005 ; Zagari et al 2008 ).…”

Section: Discussionsupporting

confidence: 91%

Impact of night-shift work on the prevalence of erosive esophagitis in shipyard male workers

Chung

Lee

Kim

2016

Int Arch Occup Environ Health

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PurposeWhether night-shift work is a risk factor for gastroesophageal reflux disease is controversial. The aim of this study was to investigate the association between night-shift work and other factors, and erosive esophagitis.MethodsA cross-sectional study with 6040 male shipyard workers was performed. Esophagogastroduodenoscopic examination and a survey about night-shift work status, lifestyle, medical history, educational status, and marital status were conducted in all workers. The odds ratios of erosive esophagitis according to night-shift work status were calculated by using the logistic regression model.ResultsThe prevalence of erosive esophagitis increased in the night-shift workers [odds ratio, 95 % confidence interval: 1.41 (1.03–1.94)]. According to multiple logistic regression models, night-shift work, obesity, smoking, and alcohol consumption of ≥140 g/week were significant risk factors for erosive esophagitis. By contrast, Helicobacter pylori infection was negatively associated with erosive esophagitis.ConclusionNight-shift work is suggested to be a risk factor for erosive esophagitis. Avoidance of night-shift work and lifestyle modification should be considered for prevention and management of gastroesophageal reflux disease.

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Section: Discussionsupporting

confidence: 91%

Impact of night-shift work on the prevalence of erosive esophagitis in shipyard male workers

Chung

Lee

Kim

2016

Int Arch Occup Environ Health

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“…The prevalence of RE among Koreans is reported to range from 3% to 5%, and most of the patients had mild‐grade esophagitis . However, more recent studies suggest that the prevalence of RE in Asia is increasing . This study with endoscopic diagnosis shows that overall prevalence of RE was determined to be 6.2%.…”

Section: Discussionmentioning

confidence: 67%

“…In contrast, GERD has been traditionally considered less common in the Orient, especially in the Far East. The prevalence of GERD in Korea has been believed to be low, but the incidence of GERD in Korea is expected to increase because of the longer life expectancy and more ingestion of westernized food that may induce or exacerbate GERD in Korean people . Various methods have been used to estimate the prevalence of GERD.…”

Section: Introductionmentioning

confidence: 99%

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Differences in the risk factors of reflux esophagitis according to age in Korea

et al. 2012

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The prevalence of gastroesophageal reflux disease in Korea has been believed to be low, but the incidence of gastroesophageal reflux disease in Korea is expected to increase because of the longer life expectancy and more ingestion of westernized food. The aim of this study was to report differences in the risk factors of reflux esophagitis (RE) according to age in Korea. We prospectively recruited the subjects who had RE among those who visited a health promotion center for upper gastrointestinal cancer surveillance at Hallym Medical Center (five institutions) between January 2008 and February 2009. The enrolled study participants comprised 742 subjects with RE and 1484 healthy controls. The independent risk factors of RE in young and adult group were male sex, smoking, coffee, body mass index ≥ 25, hiatal hernia, and Helicobacter pylori negativity. The risk factors of RE in elderly group were smoking, coffee, and hiatal hernia. The risk factors for RE according to age group were found to differ. In elderly group, Helicobacter pylori infection was not a significant protective factor contrary to young and adult groups.

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“…In South Korea, most of patients with EE have LA grade A or B. Patients with LA grade C or D are relatively rare …”

Section: Discussionmentioning

confidence: 99%

Randomised phase 3 trial: tegoprazan, a novel potassium‐competitive acid blocker, vs. esomeprazole in patients with erosive oesophagitis

Lee

Son²,

Kim

et al. 2019

Aliment Pharmacol Ther

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Summary Background Tegoprazan is a novel potassium‐competitive acid blocker that has a fast onset of action and can control gastric pH for a prolonged period, which could offer clinical benefit in acid‐related disorders. Aim To confirm the non‐inferiority of tegoprazan to esomeprazole in patients with erosive oesophagitis (EE). Methods In this multicentre, randomised, double‐blind, parallel‐group comparison study, 302 Korean patients with endoscopically confirmed EE (Los Angeles Classification Grades A‐D) were randomly allocated to either tegoprazan (50 or 100 mg) or esomeprazole (40 mg) treatment groups for 4 or 8 weeks. The primary endpoint was the cumulative proportion of patients with healed EE confirmed by endoscopy up to 8 weeks from treatment initiation. Symptoms, safety and tolerability were also assessed. Results The cumulative healing rates at week 8 were 98.9% (91/92), 98.9% (90/91) and 98.9% (87/88) for tegoprazan 50 mg, tegoprazan 100 mg and esomeprazole 40 mg, respectively. Both doses of tegoprazan were non‐inferior to esomeprazole 40 mg. The incidence of adverse events was comparable among the groups, and tegoprazan was well‐tolerated. Conclusion Once daily administration of tegoprazan 50 or 100 mg showed non‐inferior efficacy in healing EE and tolerability to that of esomeprazole 40 mg.

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Prevalence and Risk Factor of Erosive Esophagitis Observed in Korean National Cancer Screening Program

Cited by 18 publications

References 23 publications

Impact of night-shift work on the prevalence of erosive esophagitis in shipyard male workers

Impact of night-shift work on the prevalence of erosive esophagitis in shipyard male workers

Differences in the risk factors of reflux esophagitis according to age in Korea

Randomised phase 3 trial: tegoprazan, a novel potassium‐competitive acid blocker, vs. esomeprazole in patients with erosive oesophagitis

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