Prevalence and Risk Factors Associated With the Presence of Peripheral Neuropathy in Patients With Hepatitis C Virus Infection

Téllez‐Zenteno, José F.; Calva-Mercado, Juan José; Weder-Cisneros, Natalie; Estañol, Bruno; Montes, J.L.; Rosales, Maria; Plascencia, N. R.; Domínguez, Juan Carlos; Soto-Ramírez, Luis Enrique; Ortiz-Nieva, Gabriela; Garcı́a-Ramos, Guillermo

doi:10.1097/00131402-200303000-00002

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…Specifically, we observed that age above 55 years was associated with peripheral neuropathy. This is in accordance with previous reports in Egypt, Mexico and Italy [ 13 , 26 , 31 , 32 ], who reported older age as a predictor of peripheral neuropathy. Patients aged greater than 55 years were 6 times more likely to develop peripheral neuropathy than their younger counterparts in our study.…”

Section: Discussionsupporting

confidence: 93%

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Neurological manifestations in chronic hepatitis C patients receiving care in a reference hospital in sub-Saharan Africa: A cross-sectional study

et al. 2018

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BackgroundChronic hepatitis C infection is a major public health concern, with a high burden in Sub-Saharan Africa. There is growing evidence that chronic hepatitis C virus (HCV) infection causes neurological complications. This study aimed at assessing the prevalence and factors associated with neurological manifestations in chronic hepatitis C patients.MethodsThrough a cross-sectional design, a semi-structured questionnaire was used to collect data from consecutive chronic HCV infected patients attending the outpatient gastroenterology unit of the Douala General Hospital (DGH). Data collection was by interview, patient record review (including HCV RNA quantification, HCV genotyping and the assessment of liver fibrosis and necroinflammatory activity), clinical examination complemented by 3 tools; Neuropathic pain diagnostic questionnaire, Brief peripheral neuropathy screen and mini mental state examination score. Data were analysed using Statistical package for social sciences version 20 for windows.ResultsOf the 121 chronic hepatitis C patients (51.2% males) recruited, 54.5% (95% Confidence interval: 46.3%, 62.8%) had at least one neurological manifestation, with peripheral nervous system manifestations being more common (50.4%). Age ≥ 55 years (Adjusted Odds Ratio: 4.82, 95%CI: 1.02–18.81, p = 0.02), longer duration of illness (AOR: 1.012, 95%CI: 1.00–1.02, p = 0.01) and high viral load (AOR: 3.40, 95% CI: 1.20–9.64, p = 0.02) were significantly associated with neurological manifestations. Peripheral neuropathy was the most common neurological manifestation (49.6%), presenting mainly as sensory neuropathy (47.9%). Age ≥ 55 years (AOR: 6.25, 95%CI: 1.33–29.08, p = 0.02) and longer duration of illness (AOR: 1.01, 1.00–1.02, p = 0.01) were significantly associated with peripheral neuropathy.ConclusionOver half of the patients with chronic hepatitis C attending the DGH have a neurological manifestation, mainly presenting as sensory peripheral neuropathy. Routine screening of chronic hepatitis C patients for peripheral neuropathy is therefore necessary, with prime focus on those with older age and longer duration of illness.

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Section: Discussionsupporting

confidence: 93%

“…Our findings are lower than the 58% reported by Telez-Zenteno et al . in Mexico [ 31 ] and 68% by Biasiotta et al . in Italy [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Neurological manifestations in chronic hepatitis C patients receiving care in a reference hospital in sub-Saharan Africa: A cross-sectional study

et al. 2018

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“…18 A crosssectional clinical and electrophysiological study of 31 HCV-infected Mexican patients detected evidence of neuropathy in 58%. 19 In a prospective electrophysiological study of 89 HCV-infected patients with detectable cryoglobulinemia, peripheral neuropathy was detected in 37%. 20 A cross-sectional clinical and electrodiagnostic study to determine the prevalence of neuropathy of 78 Brazilian patients with HCV infection detected predominantly multiple mononeuropathy in 34% of patients.…”

Section: Neuropathy Associated With Hepatitis C Virus Infection Prevamentioning

confidence: 99%

“…17 In the study of Téllez-Zenteno et al, risk factors for neuropathy were positive rheumatoid factor, cryoglobulinemia, and high viral load as well as advanced patient age, prolonged time of evolution, and low complement level. 19 Zaltron et al showed that neuropathy was associated with the presence of ''symptomatic'' cryoglobulinemia, older patient age, higher rheumatoid factor reactivity and IgM levels, and reduced complement C4 activity; neuropathy was unrelated to cryocrit and type of cryoglobulinemia. 20 In a prospective clinical, serologic, electrodiagnostic, and morphologic study of 51 HCV-infected patients with and without cryoglobulinemia, the presence of cryoglobulin in the serum was predictive of more severe and widespread neuropathic involvement; however, the vasculitic nerve damage in both groups suggested that cryoglobulins were not the unique factor involved in peripheral neuropathy.…”

Section: Risk Factors For Neuropathymentioning

confidence: 99%

Neuromuscular Diseases Associated With Chronic Hepatitis C Virus Infection

Stübgen

2011

Journal of Clinical Neuromuscular Disease

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Hepatitis C virus (HCV) infection is a growing international health problem, and more than 170 million people are chronic carriers. Up to 50% of HCV-positive patients develop at least one extrahepatic manifestation during the course of disease. To varying degrees of certainty, there is evidence of an association between chronic HCV infection and a variety of neuromuscular diseases. The pathogenesis of most extrahepatic diseases remains unclear but possibly includes HCV lymphotropism and/or HCV-induced autoantibodies. The therapeutic approach to HCV-associated autoimmune disorders entails eradication of HCV with one of the recombinant interferon-alpha preparations with or without additional immunosuppressive drugs.

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Infektiologische Ursachen peripherer Neuropathien

Svaèina¹,

Lehmann²

2016

NeuroTransmitter

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Prevalence and Risk Factors Associated With the Presence of Peripheral Neuropathy in Patients With Hepatitis C Virus Infection

Cited by 3 publications

References 16 publications

Neurological manifestations in chronic hepatitis C patients receiving care in a reference hospital in sub-Saharan Africa: A cross-sectional study

Neurological manifestations in chronic hepatitis C patients receiving care in a reference hospital in sub-Saharan Africa: A cross-sectional study

Neuromuscular Diseases Associated With Chronic Hepatitis C Virus Infection

Infektiologische Ursachen peripherer Neuropathien

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