Prevalence and risk factors associated with chronic kidney disease in an adult population from southern China

Chen, Wei; Chen, Wei‐Qing; Wang, Hui; Dong, Xin; Liu, Qinghua; Mao, Haiping; Tan, Jiaqing; Lin, Jianxiong; Zhou, Feng; Luo, Ning; He, Huijuan; Johnson, Richard J.; Zhou, Shu‐Feng; Yu, Xueqing

doi:10.1093/ndt/gfn604

Cited by 139 publications

(164 citation statements)

References 29 publications

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“…Almost one half of them had at least one of the three markers: 25% had only MAU and/or proteinuria but not diminished eGFR, while 21% had eGFR below 60 mL/min/1.73 m 2 -14% without MAU and proteinuria and 7% with MAU and/or proteinuria. These results cannot be compared with those obtained in several massive screenings carried out in the general population where the prevalence of GFR below 60 mL/min/1.73 m 2 was between 3.2 and 11.2% 2,11,17,26,27 and albuminuria between 2.4 and 15.6%. 2,11,[26][27][28][29] The almost twice as high prevalence of CKD markers found here, where three groups of patients at increased risk of CKD were involved, is comparable to values determined in studies that also targeted different at-risk populations.…”

Section: Discussionmentioning

confidence: 59%

“…These results cannot be compared with those obtained in several massive screenings carried out in the general population where the prevalence of GFR below 60 mL/min/1.73 m 2 was between 3.2 and 11.2% 2,11,17,26,27 and albuminuria between 2.4 and 15.6%. 2,11,[26][27][28][29] The almost twice as high prevalence of CKD markers found here, where three groups of patients at increased risk of CKD were involved, is comparable to values determined in studies that also targeted different at-risk populations. The initial data of the well-known kidney early evaluation program (KEEP) that targeted persons with diabetes, hypertension, or a family history of diabetes or hypertension or CKD showed that, among 6071 participants, 29% had albuminuria and 16% had eGFR below 60 mL/min/1.73 m 2 .…”

Section: Discussionmentioning

confidence: 59%

“…Age, hypertension, and diabetes were reported as significant variables associated with reduced eGFR in both developed 2,11,37 and developing countries. 17,26,27 The lack of diabetes as a significant predictor of reduced eGFR in our study might be partly explained by the low proportion of diabetics included. As already mentioned, most patients with diabetes are not monitored by the general practitioners who recruited patients for our screening study but in special advice centers for diabetics.…”

Section: Discussionmentioning

confidence: 83%

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Screening of a Population at Risk of Chronic Kidney Disease: Analysis of Factors Associated with Low eGFR and Microalbuminuria

Ležaić¹,

Dimković²,

Peković³

et al. 2011

Renal Failure

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Background and objective: Numerous screenings of chronic kidney disease (CKD) have been performed all over the world. This screening study was undertaken with the aim of estimating the prevalence of low glomerular filtration rate (eGFR) and microalbuminuria (MAU) and/or proteinuria in a population at risk for CKD and to detect factors associated with these CKD markers. Materials and methods: This cross-sectional study included 1617 patients without previously known kidney disease who came for regular check-ups to their general practitioners in 13 Belgrade health centers over a 3-month period. Patients selected were as follows: 1316 with hypertension, 208 with type 2 diabetes, and 93 older than 60 years without hypertension or diabetes. Screening included a questionnaire, blood pressure measurement, single MAU dipstick measurement (Micral-test ® strip) and proteinuria and GFR estimation by Modification of Diet in Renal Disease. Results: MAU was found in 419 (25.9%) patients, proteinuria in 163 (10.1%), and eGFR < 60 mL/min/1.73 m 2 in 370 (22.9%). Multivariate logistic regression analysis revealed that female gender, age, duration of hypertension, and smoking were associated with eGFR. Male gender, hypertension, treatment with angiotensinconverting enzyme inhibitors, proteinuria, and systolic blood pressure were associated with MAU. Conclusions: High prevalence of MAU/proteinuria and reduced eGFR were found in high-risk persons for CKD. Besides nonmodifiable, significant modifiable factors for MAU were use of angiotensin-converting enzyme inhibitors and strict regulation of hypertension and the factor for reduced eGFR was smoking.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 83%

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Screening of a Population at Risk of Chronic Kidney Disease: Analysis of Factors Associated with Low eGFR and Microalbuminuria

Ležaić¹,

Dimković²,

Peković³

et al. 2011

Renal Failure

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“…The initial data of the The Kidney Early Evaluation Program (KEEP) program that targeted persons with diabetes, hypertension, or a family history of diabetes or hypertension or CKD showed that among 6,071 participants 29% had ≥A2 categoriy of albuminuria and 16% had eGFR below 60 mL/min/1.73 m 2 [18]. In the present study 15.1% of all patients had high albuminuria and 17.9% had eGFR below 60 mL/min/1.73 m 2 . Our previous study included 1617 patients with hypertension, diabetes and age over 60 years, who were unaware of earlier kidney disease.…”

Section: Discussionmentioning

confidence: 55%

“…In several mass screenings carried out in the general population the prevalence of eGFR below 60 ml/min/1.73m 2 was between 3.2% and 11.2% [12][13][14][15] and ≥A2 categoriy of albuminuria between 2.4% and 15.6% [12][13][14][15][16][17]. In screening studies that included subjects at risk for CKD even higher prevalence was reported.…”

Section: Discussionmentioning

confidence: 99%

Classification of patients at risk for chronic kidney disease by use of eGFR and albuminuria

Seferović¹,

Ležaić

2015

Biomedicinska istraž.

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SummaryIntroduction. Screening for chronic kidney disease (CKD) has been advised in high-risk populations. However, data on the prevalence of early asymptomatic stages vary and depend on the definition of CKD. In the present study subjects at risk for CKD (patients with diabetes mellitus type 2-DM2, with hypertension and older than 60 years without diabetes and hypertension) were classified in categories defined by eGFR and albuminuria staging system.

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Quantitative determination of human IgA subclasses and their Fc‐glycosylation patterns in plasma by using a peptide analogue internal standard and ultra‐high‐performance liquid chromatography/triple quadrupole mass spectrometry

Chen

Shiao

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale Glycosylation on immunoglobulins is important for the immune function. In this study, we developed and validated a method for the absolute quantification of IgA subclasses and relative quantification of IgA‐Fc glycopeptides by using affinity purification and ultrahigh‐performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS). Only micro‐volumes of plasma were required from each sample and we also applied the method to discover IgA and IgA‐glycopeptide profiles in patients with chronic kidney diseases and IgA nephropathy. Methods Peptide M affinity beads were used to purify IgA, and a cost‐effective peptide analogue was added as internal standard. With an efficient on‐bead digestion process, purified samples were analyzed by UHPLC/MS/MS in multiple reaction monitoring mode. Results Correlation coefficients were greater than 0.999 for the IgA1 and IgA2 calibration curves and greater than 0.994 for glycopeptide regression curves. Intraday and interday precisions for IgA1 and IgA2 were <1.6% and <5.1% RSD, respectively. Intraday and interday accuracies ranged from 102.6 to 114.9% and 103.5 to 113.5% for IgA1 and IgA2, respectively. Stabilities of IgA1 and IgA2 at −80°C for 7 to 15 days ranged from 96.0 to 109.4%, respectively. The Pearson's correlation coefficient was 0.916 when comparing the IgA quantification results of the 30 clinical samples by using ELISAs and the developed UHPLC/MS/MS method. Compared with healthy controls, IgA and IgA‐glycopeptides showed different profiles in patients with chronic kidney diseases and IgA nephropathy. Conclusions The developed method showed good validation results, and the absolute quantification results of IgA correlated with those from ELISA. The pilot application study showed that IgA and IgA‐glycopeptides can be potential biomarker candidates for kidney diseases, and more clinical sample applications are worth investigating.

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Prevalence and risk factors associated with chronic kidney disease in an adult population from southern China

Cited by 139 publications

References 29 publications

Screening of a Population at Risk of Chronic Kidney Disease: Analysis of Factors Associated with Low eGFR and Microalbuminuria

Screening of a Population at Risk of Chronic Kidney Disease: Analysis of Factors Associated with Low eGFR and Microalbuminuria

Classification of patients at risk for chronic kidney disease by use of eGFR and albuminuria

Quantitative determination of human IgA subclasses and their Fc‐glycosylation patterns in plasma by using a peptide analogue internal standard and ultra‐high‐performance liquid chromatography/triple quadrupole mass spectrometry

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