Prevalence and risk factors for symptoms of attention deficit and hyperactivity in primary snoring children

Chan, M.K.; Cherk, Sharon W.W.; Kwok, Ka‐li; Leung, Shuk-Yu; Ng, Johan Y. Y.; Lee, Rachel Shui-Ping; Man-Kiu, Tracy

doi:10.4103/prcm.prcm_15_17

Cited by 1 publication

(1 citation statement)

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“…Once an antigen binds to the mast cell, it will lead to mast cell degranulation and release of inflammatory mediators, such as histamine, serotonin and proinflammatory cytokines. This sequential reaction regulated by mast cells induces hypersensitivity, resulting in clinical manifestations associated with atopy 37 38. In addition, mast cells also promote prolonged hypersensitivity by responding to tryptase, a mast cell-derived mediator effecting type two protein-activated receptors 3 35 39.…”

Section: Discussionmentioning

confidence: 99%

A 8-Year Population-Based Cohort Study of Irritable Bowel Syndrome in Childhood with History of Atopic Dermatitis

Tsai

Wang

Shen

et al. 2018

Journal of Investigative Medicine

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Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder affecting a large number of people worldwide. Based on the concept of central sensitization, we conducted a population-based cohort analysis to investigate the risk of IBS in children with atopic dermatitis (AD) as one of the first steps in the atopic march. From 2000 to 2007, 1 20 014 children with newly diagnosed AD and 1 20 014 randomly selected non-AD controls were included in the study. By the end of 2008, incidences of IBS in both cohorts and the AD cohort to non-AD cohort hazard ratios (HRs) and CIs were measured. The incidence of IBS during the study period was 1.45-fold greater (95% CI: 1.32 to 1.59) in the AD cohort than in the non-AD cohort (18.8 vs 12.9 per 10 000 person-years). The AD to non-AD HR of IBS was greater for girls (1.60, 95% CI: 1.39 to 1.85) and children≥12 years (1.59, 95% CI: 1.23 to 2.05). The HR of IBS in AD children increased from 0.84 (95% CI: 0.75 to 0.94) for those with ≤3 AD related visits to 16.7 (95% CI: 14.7 to 18.9) for those with >5 visits (P<0.0001, by the trend test). AD children had a greater risk of developing IBS. Further research is needed to clarify the role of allergy in the pathogenesis of IBS.

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