Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children: A cohort study

Kumar, Riten; Rodriguez, Vilmarie; Matsumoto, Jane M.; Khan, Shakila P.; Weaver, Amy L.; McBane, Robert D.; Beebe, Timothy J.; Heit, John A.

doi:10.1016/j.thromres.2014.12.005

Cited by 27 publications

(32 citation statements)

References 20 publications

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“…Treatment of DVT with anticoagulant therapy is commonly recommended in order to prevent clot propagation/embolization and long‐term morbidity from PTS. These are serious consequences that can result in tremendous morbidity for patients . Surprisingly, there was no difference in the incidence of PTS, incidence of clot resolution or improvement, incidence of PE ( n = 0), or clot propagation ( n = 0) between patients treated with anticoagulation and those who were not treated with anticoagulation.…”

Section: Discussionmentioning

confidence: 94%

“…These are serious consequences that can result in tremendous morbidity for patients. 27,39,40 Surprisingly, there was no difference in the incidence of PTS, incidence of clot resolution or improvement, incidence of PE (n = 0), or clot propagation (n = 0) between patients treated with anticoagulation and those who were not treated with anticoagulation. In other cohorts of pediatric patients, 28 and high bleeding risk present a challenge for providers; the risk of bleeding due to prophylactic doses of enoxaparin is equivocal in adults 43,44 and unknown in children.…”

Section: Discussionmentioning

confidence: 96%

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Venous thromboembolism in pediatric trauma patients: Ten‐year experience and long‐term follow‐up in a tertiary care center

Leeper

Vissa

Cooper

et al. 2017

Pediatric Blood & Cancer

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 96%

Venous thromboembolism in pediatric trauma patients: Ten‐year experience and long‐term follow‐up in a tertiary care center

Leeper

Vissa

Cooper

et al. 2017

Pediatric Blood & Cancer

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“…). PTS has been found in up to 63% of children diagnosed with DVT, especially in those with multiple vein segments involved and lack of radiographic DVT resolution . Patients who developed an upper extremity DVT due to overuse (sports, weight lifting, musical instrument playing) are more likely to develop PTS versus CVC‐related DVTs .…”

Section: Long‐term Sequelaementioning

confidence: 99%

Deep vein thrombosis in pediatric patients

Jaffray

2017

Pediatric Blood & Cancer

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Due to advances in caring for critically ill children and those with chronic diseases, rates of deep vein thrombosis (DVT) are increasing in children. Risk factors consist of central venous catheters, chronic medical conditions, thrombophilia, and various medications. Compression Doppler ultrasonography is the method most commonly used to diagnose DVT, and patients will usually present with pain and swelling of the affected limb. Anticoagulation via subcutaneous injection is the most common treatment regime for children with DVT, and the new, direct oral anticoagulants are currently under investigation. Prevention techniques are not established, but clinical studies are addressing this need.

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“…PTS, characterized by venous insufficiency, is a chronic complication of VTE; the symptoms of PTS range from mild edema to chronic pain, swelling, discoloration, and ulceration of the affected limb [ 29 ]. In children, the risk of PTS following VTE is estimated at 10%–70% [ 30 ]. The likelihood of PTS is higher in the first 2 years of VTE, and it continues to increase over time [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Venous thromboembolism in pediatric patients: a single institution experience in Korea

Choi

Kim

et al. 2016

Blood Res

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BackgroundWhile venous thromboembolism (VTE) is uncommon, its incidence is increasing in children. We aimed to evaluate the incidence, risk factors, treatment, and outcome of pediatric VTE cases at a single tertiary hospital in Korea.MethodsWe retrospectively analyzed the records of consecutive pediatric VTE patients admitted to the Seoul National University Bundang Hospital between April 2003 and March 2016.ResultsAmong 70,462 hospitalizations, 25 pediatric VTE cases were identified (3.27 cases per 10,000 admissions). Fifteen patients (60%) were male, 8 were neonates (32%), and the median age at diagnosis was 10.9 years (range, 0 days‒17 yr). Doppler ultrasonography was the most frequently used imaging modality. Thrombosis occurred in the intracerebral (20%), upper venous (64%), lower venous (12%), and combined upper and lower venous systems (4%). Twenty patients (80%) had underlying clinical conditions including venous catheterization (24%), malignancy (20%), and systemic diseases (12%). Protein C, protein S, and antithrombin deficiencies occurred in 2 of 13, 4 of 13, and 1 of 14 patients tested, respectively. Six patients were treated with heparin followed by warfarin, while 4 were treated with heparin or warfarin. Thrombectomy and inferior vena cava filter and/or thrombolysis were performed in 5 patients. Two patients died of pulmonary embolism, and 2 developed a post-thrombotic syndrome.ConclusionCompared with the reports from Western countries, VTE occurrence was lower in the Korean pediatric population under study, although similar clinical characteristics including bimodal age distribution, underlying diseases, treatment pattern, and outcomes were observed.

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Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children: A cohort study

Cited by 27 publications

References 20 publications

Venous thromboembolism in pediatric trauma patients: Ten‐year experience and long‐term follow‐up in a tertiary care center

Venous thromboembolism in pediatric trauma patients: Ten‐year experience and long‐term follow‐up in a tertiary care center

Deep vein thrombosis in pediatric patients

Venous thromboembolism in pediatric patients: a single institution experience in Korea

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