Prevalence and risk factors for cerebral microbleeds in elderly Chinese patients with arteriosclerotic cardiovascular diseases: A single-center study

Chen, Yuhui; Liu, Fang; Chen, Juan; Wu, Dongdong; He, Jing; Chen, Min; Liu, Yinhong

doi:10.1016/j.jstrokecerebrovasdis.2023.107268

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…These findings are consistent with previous research that has demonstrated similar associations. [ 24 25 ] A recent meta-analysis suggested that statin therapy might increase the risk of lobar CMB formation. [ 26 ] Potential explanations are that reduced cholesterol levels weaken the stability of cell membranes and endothelium in the small arteries of the brain, making them more susceptible to rupture, thus increasing the likelihood of CMBs.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors of Cerebral Microbleeds in Community-Dwelling Adults in Urban Delhi

Jali,

Mishra,

Vibha

et al. 2024

Annals of Indian Academy of Neurology

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Background: Several observational studies have reported the prevalence of cerebral microbleeds (CMBs) and their risk factors in an elderly population. Any information in this regard is currently lacking from India. Aim of this study was to estimate the prevalence, risk factors of CMBs, and association with cognition in an Indian urban population aged 50 years and above. Methods: Household surveys were conducted as part of ongoing Longitudinal Cognition and Aging Research on Population of the National Capital Region (LoCARPoN) study in areas of urban Delhi. Magnetic resonance imaging of the brain was performed in 2599 participants. Using standard neuropsychological battery, mean Z-scores for each domain (memory, executive, information) were derived. Binary and stepwise logistic regression models were used to determine associated risk factors for the presence of CMB and its association with cognitive domains. Results: The prevalence of CMBs was 14.42% (95% confidence interval [CI]: 13.06–15.73). Of these, 203 (7.81%) participants had single CMBs and 172 (6.61%) had multiple microbleeds (≥2). Higher prevalence was observed in older age (60–70 years: odds ratio [OR]: 1.25 [95% CI: 0.93–1.67]; 70–80 years: OR: 2.05 [95% CI: 1.48–2.84]; ≥80 years: OR: 3.27 [95% CI: 1.97–5.44]) compared to individuals in the age group 50–60 years. History of stroke (OR: 2.97 [95% CI: 1.56–5.66]), hypertension (OR: 1.36 [95% CI: 1.05–1.75]), and smoking (OR: 1.43 [95% CI: 1.11–1.85]) was associated with at least one CMB. Multiple CMBs were associated with worse scores in memory and executive domains. Conclusion: Older age, hypertension, history of stroke, and history of smoking emerged as important risk factors for the presence of multiple CMBs. Follow-up study is required to determine implications of CMBs.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors of Cerebral Microbleeds in Community-Dwelling Adults in Urban Delhi

Jali,

Mishra,

Vibha

et al. 2024

Annals of Indian Academy of Neurology

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Prevalence and Risk Factors of Cerebral Microbleeds among Egyptian Patients with Acute Ischemic Stroke

Nasreldein,

Shoamnesh,

Foli

et al. 2024

Neuroepidemiology

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Background: Cerebral microbleeds (CMBs) are markers of underlying hemorrhage-prone cerebral small vessel disease detected on MRI. They are associated with heightened risk of stroke and cognitive decline. The prevalence of CMBs among Egyptian patients with ischemic stroke is not well studied. Our aim was to detect the prevalence of CMBs and associated risk factors among Egyptian patients with ischemic stroke. Methods: A prospective, cross-sectional, single center study of consecutive patients with ischemic stroke. Patients were recruited between January 2021 to January 2022 at the Assuit University hospital in the south of Egypt. Patients with known bleeding diathesis were excluded. All participants underwent full neurological assessment, urgent laboratory investigations and MRI with T2* sequence. Results: The study included 404 patients, 191 (47.3%) of them were females. The mean age of the study population was 61±1 years and the mean NIHSS on admission was 12±5. The prevalence of CMB was 26.5%, of whom 6.5% were young adults (age ≤ 45 years). CMBs were detected in 34.6% of patients with stroke caused by large artery atherosclerosis, 28.0% small vessel disease stroke subtype, 25.2% stroke of undetermined cause and 12.1% in cardioembolic stroke. History of AF, hypertension, dyslipidemia, Fazekas score > 2, dual antiplatelets use, combined antiplatelet with anticoagulant treatment and thrombolytic therapy remained independently associated with CMBs following multivariable regression analyses. Conclusion: The high number of identified CMBs needs to inform subsequent therapeutic management of these patients. We are unable to determine whether the association between CMBs and antithrombotic use is a causal relationship or rather confounded by indication in our observational study. To understand more about the underlying cause of this finding, more studies are needed.

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Prevalence and risk factors for cerebral microbleeds in elderly Chinese patients with arteriosclerotic cardiovascular diseases: A single-center study

Cited by 2 publications

References 37 publications

Prevalence and Risk Factors of Cerebral Microbleeds in Community-Dwelling Adults in Urban Delhi

Prevalence and Risk Factors of Cerebral Microbleeds in Community-Dwelling Adults in Urban Delhi

Prevalence and Risk Factors of Cerebral Microbleeds among Egyptian Patients with Acute Ischemic Stroke

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