Prevalence and Risk Factors for Hepatitis C Virus Infection Among General Population in Luxor Governorate, Egypt

El-Adly, Ahmed M.; Wardany, Ahmed A.; Morsy, Mohamed F. M.

doi:10.21608/amj.2020.67535

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…Before 2008, a commonly reported risk factor of HCV transmission in Egypt was related to the iatrogenic transmission at health care facilities. Indeed, factors such as old age, rural residence, unsafe injection practices, a history of operations, dental procedures, hospitalization, blood transfusion, and PAT were significantly associated with HCV transmission in several studies conducted since 2008 (Soliman et al, 2019, Elhendawy et al, 2020 andEl-Adly et al, 2020). These observations supported the notion that healthcare exposures act as driving factors of HCV transmission in Egypt.…”

Section: Discussionmentioning

confidence: 65%

Hepatitis C Virus Infection Rates Among Egyptian Blood Donors After Implementation of the National Treatment Program

2022

Al-Azhar Medical Journal

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Section: Discussionmentioning

confidence: 65%

Hepatitis C Virus Infection Rates Among Egyptian Blood Donors After Implementation of the National Treatment Program

2022

Al-Azhar Medical Journal

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“…Blood transmission as a risk factor for HCV and HBV has greatly diminished after the introduction of effective screening; however, it remained an important past and a potential current risk for disease transmission 34,36–38 . This study found that the history of blood transfusion remained associated with HCV and HBV infection.…”

Section: Discussionmentioning

confidence: 68%

“…10 Blood transmission as a risk factor for HCV and HBV has greatly diminished after the introduction of effective screening; however, it remained an important past and a potential current risk for disease transmission. 34,[36][37][38] This study found that the history of blood transfusion remained associated with HCV and HBV infection. To create a cost-effective, efficient and sustainable national blood system, the MoHP developed a national blood policy in 2015 to define organisational, financial and legal measures.…”

Section: Ta B L Ementioning

confidence: 62%

Evidence for the elimination of viral hepatitis B and C in Egypt: Results of a nationwide survey in 2022

Kandeel,

Fahim,

Abukamar

et al. 2024

Liver International

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IntroductionViral hepatitis C (HCV) and B (HBV) were at the top of Egypt's most significant public health challenges, with an estimated 14.7% of its population having antibodies to HCV in 2008. Egypt issued an ambitious action plan in 2014 to eliminate viral hepatitis through strengthening infection control and improving patient care. In 2018, an extensive HCV mass screening campaign was conducted for the entire country's population with treating more than 4 million patients with antivirals. This study aimed to evaluate the current prevalence of viral hepatitis in Egypt after all these efforts.MethodsA cross‐sectional household cluster survey was conducted in all 27 Egyptian governorates to obtain a representative sample of Egypt's population. Subjects aged 1–70 years were interviewed using a standardised questionnaire that included demographics, viral hepatitis knowledge, previous infection and risk factors data. Laboratory testing was performed for all subjects for anti‐HCV and HBsAg using chemiluminescence. Subjects positive for anti‐HCV were further tested for HCV‐RNA by RT‐PCR. Prevalence rates were calculated by demographic groups and compared to the demographic health survey 2015 results.ResultsOf 20 881 subjects interviewed, 48.8% were males, 20.2% were children <15 years of age, and 53.7% were residents of rural areas. Of all subjects, 92 (0.4%) were HCV‐infected, 1577 (7.6%) were anti‐HCV positive and 177 (0.8%) were HBV‐chronically infected, including one patient who had mixed HBV and HCV current infection. The prevalence of HCV‐current and HBV chronic infections decreased by 93% and 20%, respectively, compared to 2015.ConclusionsEgypt achieved the elimination of the viral hepatitis goal. To maintain low rates of viral hepatitis, community health education, in addition to maintaining infection control and blood safety programs, is essential.

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Current situation of viral hepatitis in Egypt

Elbahrawy

Ibrahim

Eliwa

et al. 2021

Microbiology and Immunology

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An estimated 8–10 million people suffer from viral hepatitis in Egypt. Hepatitis A virus (HAV) and hepatitis E virus (HEV) are the major causes of viral hepatitis in Egypt as 50% or more of the Egyptian population are already exposed to HAV infection by the age of 15. In addition, over 60% of the Egyptian population test seropositive for anti‐HEV in the first decade of life. HEV mainly causes self‐limiting hepatitis; however, cases of fulminant hepatitis and liver failure were reported in Egypt. Hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis D virus (HDV) are the main causes of chronic hepatitis, liver cirrhosis, and liver cancer (hepatocellular carcinoma [HCC]) in Egypt. Globally, Egypt had the highest age‐standardized death rate due to cirrhosis from 1990 to 2017. The prevalence rate of HBV (1.3%–1.5%) has declined after national infantile immunization. Coinfection of HBV patients with HDV is common in Egypt because HDV antibodies (IgG) vary in range from 8.3% to 43% among total HBV patients. After the conduction of multiple national programs to control HCV infection, a lower rate of HCV prevalence (4.6%) was recently reported. Data about the incidence of HCV after treatment with direct antiviral agents (DAAs) are lacking. An HCC incidence of 29/1000/year in cirrhotic patients after DAA treatment is reported. A higher rate of infiltrative pattern among HCC patients after DAA treatment is also recognized. Viral hepatitis is one of the major public health concerns in Egypt that needs more attention and funding from health policymakers.

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Prevalence and Risk Factors for Hepatitis C Virus Infection Among General Population in Luxor Governorate, Egypt

Cited by 4 publications

References 25 publications

Hepatitis C Virus Infection Rates Among Egyptian Blood Donors After Implementation of the National Treatment Program

Hepatitis C Virus Infection Rates Among Egyptian Blood Donors After Implementation of the National Treatment Program

Evidence for the elimination of viral hepatitis B and C in Egypt: Results of a nationwide survey in 2022

Current situation of viral hepatitis in Egypt

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