Prevalence and risk factors for carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae among patients prior to bowel surgery

Pfeffer, Iris; Zemel, Meir; Kariv, Yehuda; Mishali, Hagit; Adler, Amos; Braun, Theodore E. D.; Klein, Anat; Matalon, M. Kazma; Klausner, Joseph M.; Carmeli, Yehuda; Schwaber, Mitchell J.

doi:10.1016/j.diagmicrobio.2016.04.002

Cited by 14 publications

(11 citation statements)

References 20 publications

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“…Studies from Europe suggest that ESBL enteric colonization ranges between 18% and 29% among patients who undergo colorectal surgery, with a 2-fold increase in deep SSI among patients with enteric ESBL-producing Enterobacteriaceae colonization. 10,11 Similar to a previous study, 11 the risk of SSI, particularly deep SSI, remains high in ESBL-prevalent regions. On the contrary, our population included all patients who underwent clean-contaminated, contaminated, or dirty abdominal surgical procedures.…”

Section: Discussionsupporting

confidence: 75%

Outcomes of extended-spectrum beta-lactamases producing Enterobacteriaceae colonization among patients abdominal surgery patients

Apisarnthanarak

Kondo

Mingmalairak

et al. 2019

Infect. Control Hosp. Epidemiol.

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Section: Discussionsupporting

confidence: 75%

Outcomes of extended-spectrum beta-lactamases producing Enterobacteriaceae colonization among patients abdominal surgery patients

Apisarnthanarak

Kondo

Mingmalairak

et al. 2019

Infect. Control Hosp. Epidemiol.

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“…Additionally, in clinical settings, one study raised concern about the real efficiency of antibiotic prophylaxis post-bowel surgery on ESBL carriage and subsequent infection. This is because in this report, immunosuppressive therapy and antibiotic use in the previous 3 months were independent risk factors for ESBL rectal carriage in this patients’ category (Pfeffer et al, 2016). Moreover, in this country, the carriage of carbapenem resistance was significantly higher to ESBL positive Enterobacteriaceae in view of the number of reports.…”

Section: Distribution Of Multi-drug Resistant Organisms In Humansmentioning

confidence: 50%

Understanding the Epidemiology of Multi-Drug Resistant Gram-Negative Bacilli in the Middle East Using a One Health Approach

et al. 2019

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In the last decade, extended-spectrum cephalosporin and carbapenem resistant Gram-negative bacilli (GNB) have been extensively reported in the literature as being disseminated in humans but also in animals and the environment. These resistant organisms often cause treatment challenges due to their wide spectrum of antibiotic resistance. With the emergence of colistin resistance in animals and its subsequent detection in humans, the situation has worsened. Several studies reported the transmission of resistant organisms from animals to humans. Studies from the middle east highlight the spread of resistant organisms in hospitals and to a lesser extent in livestock and the environment. In view of the recent socio-economical conflicts that these countries are facing in addition to the constant population mobilization; we attempt in this review to highlight the gaps of the prevalence of resistance, antibiotic consumption reports, infection control measures and other risk factors contributing in particular to the spread of resistance in these countries. In hospitals, carbapenemases producers appear to be dominant. In contrast, extended spectrum beta lactamases (ESBL) and colistin resistance are becoming a serious problem in animals. This is mainly due to the continuous use of colistin in veterinary medicine even though it is now abandoned in the human sphere. In the environment, despite the small number of reports, ESBL and carbapenemases producers were both detected. This highlights the importance of the latter as a bridge between humans and animals in the transmission chain. In this review, we note that in the majority of the Middle Eastern area, little is known about the level of antibiotic consumption especially in the community and animal farms. Furthermore, some countries are currently facing issues with immigrants, poverty and poor living conditions which has been imposed by the civil war crisis. This all greatly facilitates the dissemination of resistance in all environments. In the one health concept, this work re-emphasizes the need to have global intervention measures to avoid dissemination of antibiotic resistance in humans, animals and the environment in Middle Eastern countries.

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“…As mentioned, the risk of ESBL-producing Enterobacteriaceae infections is higher in colonized than in non-colonized recipients [22,72]. Besides, screening for colonized patients could help increase infection control [73].…”

Section: Should Intestinal Colonization By Esbl-producing Enterobactementioning

confidence: 99%

Management of multidrug resistant Gram-negative bacilli infections in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations

Aguado

Silva

Fernández‐Ruiz

et al. 2018

Transplantation Reviews

124

139

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Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant (MDR) Gram-negative bacilli (GNB), as they are frequently exposed to antibiotics and the healthcare setting, and are regulary subject to invasive procedures. Nevertheless, no recommendations concerning prevention and treatment are available. A panel of experts revised the available evidence; this document summarizes their recommendations: (1) it is important to characterize the isolate's phenotypic and genotypic resistance profile; (2) overall, donor colonization should not constitute a contraindication to transplantation, although active infected kidney and lung grafts should be avoided; (3) recipient colonization is associated with an increased risk of infection, but is not a contraindication to transplantation; (4) different surgical prophylaxis regimens are not recommended for patients colonized with carbapenem-resistant GNB; (5) timely detection of carriers, contact isolation precautions, hand hygiene compliance and antibiotic control policies are important preventive measures; (6) there is not sufficient data to recommend intestinal decolonization; (7) colonized lung transplant recipients could benefit from prophylactic inhaled antibiotics, specially for Pseudomonas aeruginosa; (8) colonized SOT recipients should receive an empirical treatment which includes active antibiotics, and directed therapy should be adjusted according to susceptibility study results and the severity of the infection.

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Prevalence and risk factors for carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae among patients prior to bowel surgery

Cited by 14 publications

References 20 publications

Outcomes of extended-spectrum beta-lactamases producing Enterobacteriaceae colonization among patients abdominal surgery patients

Outcomes of extended-spectrum beta-lactamases producing Enterobacteriaceae colonization among patients abdominal surgery patients

Understanding the Epidemiology of Multi-Drug Resistant Gram-Negative Bacilli in the Middle East Using a One Health Approach

Management of multidrug resistant Gram-negative bacilli infections in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations

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