Prevalence and Risk Factors for Fatigue in Adults With Inflammatory Bowel Disease: A Systematic Review With Meta-Analysis

D’Silva, Adrijana; Fox, Danielle E; Nasser, Yasmin; Vallance, Jeff K.; Quinn, Robert R.; Ronksley, Paul E.; Raman, Maitreyi

doi:10.1016/j.cgh.2021.06.034

Cited by 72 publications

(56 citation statements)

References 65 publications

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“…First, fatigue is highly correlated with a decline of vitality or vigor. [ 14 ] A review by D’Silva et al [ 15 ] reported that the prevalence of fatigue in patients with UC was 36% and is considered common. Seventy-two percent of patients with active disease experience fatigue.…”

Section: Discussionmentioning

confidence: 99%

Daily life difficulties among patients with ulcerative colitis in Japan and the United Kingdom: A comparative study

Kawakami

Tanaka

Sakagami³

et al. 2022

Medicine

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The difficulty of life scale (DLS) instrument is used to measure specific life problems in patients with ulcerative colitis (UC). Importantly, health care providers should consider the characteristics of the country in which they support patients with UC. This cross-cultural comparison study investigated DLS among patients with UC in Japan and the United Kingdom (UK). Outpatients attending one hospital in London and one in Osaka were included. We collected patient information using the DLS questionnaire, which comprises 18 items in three domains. Mean differences between Japan and the UK were compared for the total score and each domain of the DLS. Variables with P < .05 in univariate analysis were entered into a multiple regression model. We included 142 patients from Japan and 100 patients from the UK in the analysis. Univariate results showed that UK patients had more difficulties than Japanese patients in all three domains. Multivariate results showed that only “decline of vitality or vigor” showed significantly lower difficulty scores in Japanese patients. Having four or more bowel movements per day, visible bleeding, and being a homemaker or unemployed were significantly associated with greater difficulty according to the DLS total score. The level of daily life difficulties assessed using the DLS was greater among patients in the UK than among Japanese patients. This comparative study between patients with UC in Japan and the UK demonstrated certain country-related features for domain 3, “decline of vitality or vigor,” of the DLS. The reasons why UK patients felt greater decline in vitality or vigor may be that these patients may have symptoms other than bowel symptoms; also, Japanese patients are more hesitant to express discomfort. The findings of this study might lead to a better understanding of culturally sensitive perceptions of daily life difficulties in UC.

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Section: Discussionmentioning

confidence: 99%

Daily life difficulties among patients with ulcerative colitis in Japan and the United Kingdom: A comparative study

Kawakami

Tanaka

Sakagami³

et al. 2022

Medicine

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“…It is worth noting that this domain is included in all other GPBM (except for Health Utilities Index [30]), as well as being one of the seven key domains in the PROMIS (see Olsen and Misajon [15]). Its importance is likely to reflect the increased attention and prevalence of symptoms like fatigue, exhaustion, and lack of energy [31][32][33][34][35][36]. Sleep was the second most important bolt-on dimension, accounting for 9% of explained variations in EQ-VAS.…”

Section: Discussionmentioning

confidence: 99%

Extending the EQ-5D: the case for a complementary set of 4 psycho-social dimensions

Chen

Olsen

2022

Qual Life Res

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Objectives The EQ-5D is the most widely applied preference-based health-related quality of life measure. However, concerns have been raised that the existing dimensional structure lacks sufficient components of mental and social aspects of health. This study empirically explored the performance of a coherent set of four psycho-social bolt-ons: Vitality; Sleep; Personal relationships; and Social isolation. Methods Cross-sectional surveys were conducted with online panel members from five countries (Australia, Canada, Norway, UK, US) (total N = 4786). Four bolt-ons were described using terms aligned with EQ nomenclature. Latent structures among all nine dimensions are studied using an exploratory factor analysis (EFA). The Shorrocks-Shapely decomposition analyses are conducted to illustrate the relative importance of the nine dimensions in explaining two outcome measures for health (EQ-VAS, satisfaction with health) and two for subjective well-being (the hedonic approach of global life satisfaction and an eudemonic item on meaningfulness). Sub-group analyses are performed on older adults (65 +) and socially disadvantaged groups. Results Strength of correlations among four bolt-ons ranges from 0.34 to 0.49. As for their correlations with the EQ-5D dimensions, they are generally much less correlated with four physical health dimensions than with mental health dimensions (ranged from 0.21 to 0.50). The EFA identifies two latent factors. When explaining health, Vitality is the most important. When explaining subjective well-being, Social isolation is second most important, after Anxiety/depression. Conclusion We provide evidence that further complementing the current EQ-5D-5L health state classification system with a coherent set of four bolt-on dimensions that will fill its psycho-social gap.

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“…The median total score of MFI was 61 . The scores of different MFI domains were general fatigue: 13 (10-16); physical fatigue 13 (11)(12)(13)(14)(15)(16); mental fatigue11 (7.25-13); reduced activity 11 (8.25-13) and reduced motivation 12 (10-15) (Fig. 1B).…”

Section: Prevalence and Score Of Fatiguementioning

confidence: 99%

“…High prevalence of fatigue in UC emphases the importance of additional efforts to assess and exam fatigue to improve the care and quality of life for patients. A variety of factors, including disease activity, anemia, anxiety, depression and sleep disturbance are particularly prominent in UC patients with fatigue, which have a negative impact on the quality of life and work efficiency [11,[14][15][16]. Despite this, fatigue in UC patients tend to be neglected and is poorly managed in clinical diagnosis and treatment [17].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and factors associated with fatigue in patients with ulcerative colitis in China: a cross-sectional study

Yang

et al. 2022

BMC Gastroenterol

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Background Fatigue is one of the most common symptoms reported by patients with ulcerative colitis (UC), while it has not been fully recognized and taken seriously in clinical practice. We aimed to investigate the prevalence of fatigue in patients with UC and identify the factors associated with fatigue and its severity in China. Methods A cross-sectional study was conducted in Affiliated Hospital of Nanjing University of Chinese Medicine from May 2020 to February 2021. Demographic and clinical characteristics were collected. Fatigue was evaluated with the Fatigue Severity Scale and the Multidimensional Fatigue Inventory. The Hospital Anxiety and Depression Scale, the Pittsburgh Sleep Index Scale and the Malnutrition Universal Screening Tool were respectively used to evaluate the anxiety, depression, sleep disturbance and nutritional risk of patients with UC. Results A total of 220 UC patients were enrolled in this study. The prevalence of fatigue in patients was 61.8%, of which in patients with disease activity was 68.2%, and in patients in remission was 40.0%. Univariate analysis indicated that the Montreal classification, disease activity, anemia, anxiety, depression, sleep disturbance and high nutritional risk were the factors associated with fatigue in Patients with UC. Multivariate logistic regression analysis showed that the Montreal classification (E3: E1, OR = 2.665, 95% CI = 1.134–6.216), disease activity (OR = 2.157, 95% CI = 1.055–4.410) and anxiety (OR = 2.867, 95% CI = 1.154–7.126) were related to an increased risk of fatigue. Disease activity (RC = 0.240, 95% CI = 0.193–0.674) and anxiety (RC = 0.181, 95% CI = 0.000–0.151) were associated with severity of fatigue. Conclusions This study demonstrated that the prevalence of fatigue among UC patients in China. The Montreal classification, disease activity and anxiety are associated with an increased risk of fatigue.

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Prevalence and Risk Factors for Fatigue in Adults With Inflammatory Bowel Disease: A Systematic Review With Meta-Analysis

Cited by 72 publications

References 65 publications

Daily life difficulties among patients with ulcerative colitis in Japan and the United Kingdom: A comparative study

Daily life difficulties among patients with ulcerative colitis in Japan and the United Kingdom: A comparative study

Extending the EQ-5D: the case for a complementary set of 4 psycho-social dimensions

Prevalence and factors associated with fatigue in patients with ulcerative colitis in China: a cross-sectional study

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