Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China

Yang, Yide; Zeng, Yuan; Yuan, Shuqian; Xie, Ming; Dong, Yanhui; Li, Jian; He, Quanyuan; Ye, Xiangli; Liu, Yuan; Hocher, Carl-Friedrich; Kraemer, Bernhard; Hong, Xiuqin; Hocher, Berthold

doi:10.1136/bmjopen-2020-048575

Cited by 10 publications

(11 citation statements)

References 57 publications

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“…Hyperhomocysteinemia is a significant contributor to cardiovascular and cerebrovascular illnesses, with meta-analysis revealing a rising trend in hyperhomocysteinemia prevalence in China, currently at 37.2%. 23 Previous population-based studies conducted in Guangxi and Hunan have shown that the prevalence of homocysteine was 50.8% and 35.4%, respectively, 24 , 25 both exceeding the 26.87% reported in the present study. The prevalence of homocysteine might vary due to factors such as region and population.…”

Section: Discussioncontrasting

confidence: 63%

Epidemiological Characterisation of Chronic Diseases Among Civil Servants in Hebei Province, China: A Cross-Sectional Real-World Study of Approximately 50,000 Adults

Pan,

Wang,

Jia

et al. 2024

RMHP

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Background The objective of this investigation was to explore the health status and epidemiological features of civil servants working in Hebei Province, China. Methods Data was collected through a cross-sectional survey that involved 50,039 adult civil servants in Hebei Province. The research was conducted at the Hebei Provincial Medical Examination Centre and included inquiries about demographics, health behaviours, chronic illnesses, and abnormal check-up indicators. Statistical data were used to determine the prevalence of chronic diseases and abnormal health examination indicators. Subgroup analyses by sex were then conducted to calculate the similarities and differences in health status between men and women. Results The findings of the survey indicate that 14.2% of individuals who work in civil service suffer from obesity. Additionally, a considerable proportion of this group display poor health behaviours, including smoking and alcohol consumption. Hypertension (21.03%), dyslipidaemia (10.88%), and diabetes mellitus (8.56%) were identified as the top three chronic diseases, while cardiovascular diseases were prevalent at 6.27% among civil servants. Ultrasound showed a high prevalence of fatty liver, non-smooth gallbladder and liver cysts (44.61%, 33.24% and 23.26% respectively). The occurrence of pulmonary nodules was alarmingly high at 88.48%, while thyroid nodules were found in as much as 62.65% of patients. Abnormal E/A values≤1, prostate hyperplasia, breast nodules, and carotid plaques were also prevalent, with percentages ranging from 46.76% to 63.04%. In subgroup analyses by gender, the prevalence of chronic diseases and abnormal screening indicators was consistently higher in men than in women, with the exception of thyroid nodules and thyroid surgery. Conclusion The survey revealed a large proportion of civil servants in Hebei Province, China, suffering from chronic diseases, underscoring the necessity for enhanced attention to chronic disease prevention and management in this group and emphasising the requirement for focused interventions aimed at improving health outcomes.

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Section: Discussioncontrasting

confidence: 63%

Epidemiological Characterisation of Chronic Diseases Among Civil Servants in Hebei Province, China: A Cross-Sectional Real-World Study of Approximately 50,000 Adults

Pan,

Wang,

Jia

et al. 2024

RMHP

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“…BNs outperforms Logistic regression in risk factor detection. Firstly, combined with previous study using Logistic regression for factors associated with hyperhomocysteinemia 18 and our comparison between the two models in the Result, BNs facilitates new ideas for disease relationship study and allows for the influencing factors of a certain intermediate link in the occurrence and development of HHcy. Secondly, BNs could offer more valuable information, as it’s represented by “population clustering” we mentioned in the result.…”

Section: Discussionmentioning

confidence: 99%

“…In the past, Logistic regression was employed to explore risk factors for HHcy 18 , 19 , suggesting that age, BMI, smoking, diet, total cholesterol levels and sex are significantly associated with HHcy. Yet, the model comes with some limitations.…”

Section: Introductionmentioning

confidence: 99%

Using Bayesian networks with Tabu-search algorithm to explore risk factors for hyperhomocysteinemia

Song

Qin

et al. 2023

Sci Rep

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Hyperhomocysteinemia (HHcy) is a condition closely associated with cardiovascular and cerebrovascular diseases. Detecting its risk factors and taking some relevant interventions still represent the top priority to lower its prevalence. Yet, in discussing risk factors, Logistic regression model is usually adopted but accompanied by some defects. In this study, a Tabu Search-based BNs was first constructed for HHcy and its risk factors, and the conditional probability between nodes was calculated using Maximum Likelihood Estimation. Besides, we tried to compare its performance with Hill Climbing-based BNs and Logistic regression model in risk factor detection and discuss its prospect in clinical practice. Our study found that Age, sex, α1-microgloblobumin to creatinine ratio, fasting plasma glucose, diet and systolic blood pressure represent direct risk factors for HHcy, and smoking, glycosylated hemoglobin and BMI constitute indirect risk factors for HHcy. Besides, the performance of Tabu Search-based BNs is better than Hill Climbing-based BNs. Accordingly, BNs with Tabu Search algorithm could be a supplement for Logistic regression, allowing for exploring the complex network relationship and the overall linkage between HHcy and its risk factors. Besides, Bayesian reasoning allows for risk prediction of HHcy, which is more reasonable in clinical practice and thus should be promoted.

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“…In addition, HHcy was reported to be one of the risk factors in young intracranial large-artery atherosclerotic stroke patients [ 10 ]. Although a number of studies on the risk factors of HHcy have been reported in middle-aged or older populations [ 11 ], the distribution profile of plasma Hcy levels and the risk factors of HHcy among young adults have not drawn much attention.…”

Section: Introductionmentioning

confidence: 99%

Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations

Zhao

Hou

et al. 2023

JCM

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The distribution profile of plasma homocysteine (Hcy) in young adults and its related factors are not well understood. We performed a generalized estimating equations (GEE) analysis for plasma-Hcy-correlated factors in 2436 young adults, aged 20–39 years, from a health checkup population. We observed that the mean Hcy concentration in males (16.7 ± 10.3 μmol/L) was significantly higher than that in females (10.3 ± 4.0 μmol/L), and hyperhomocysteinemia (HHcy) prevalence in males was 5.37 times than that in females (33.3% vs. 6.2%). A GEE analysis stratified by sex indicated that age (B = −0.398, p < 0.001) and LDL-C (B = −1.602, p = 0.043) were negatively correlated, while BMI (B = 0.400, p = 0.042) was positively correlated, with the Hcy level in young males. ALT (B = −0.021, p = 0.033), LDL-C (B = −1.198, p < 0.001) and Glu (B = −0.446, p = 0.006) were negatively correlated, while AST (B = 0.022, p = 0.048), CREA (B = 0.035, p < 0.001), UA (B = 0.004, p = 0.003) and TG (B = 1.042, p < 0.001) were positively correlated, with the Hcy level in young females. These results suggest that young males have a significantly higher plasma Hcy level and HHcy prevalence than young females; therefore, more attention should be paid to the reason for and effect of the higher HHcy prevalence in young males.

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Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China

Cited by 10 publications

References 57 publications

Epidemiological Characterisation of Chronic Diseases Among Civil Servants in Hebei Province, China: A Cross-Sectional Real-World Study of Approximately 50,000 Adults

Epidemiological Characterisation of Chronic Diseases Among Civil Servants in Hebei Province, China: A Cross-Sectional Real-World Study of Approximately 50,000 Adults

Using Bayesian networks with Tabu-search algorithm to explore risk factors for hyperhomocysteinemia

Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations

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