Alcohol dependence is rising in India, perhaps due to newer and greater stresses related to rapid changes in life-styles. This cross-sectional study was designed to find prevalence of psychiatric co-morbidities in outpatients with alcohol dependence syndrome (ADS) and to analyze relationship between presence of psychiatric morbidity with socio demographic and illness related factors. Data was collected from 100 consecutive outpatients with ADS using structured socio-demographic Performa and semi-structured prevalidated Alcohol intake datasheet. ADS and psychiatric co-morbidities were diagnosed by International Classification of Diseases Diagnostic criteria for research-Tenth Revision. (ICD-10 DCR) Prevalence of psychiatric co-morbidity was 56%. The most common psychiatric disorder was depressive disorder (39%). 42.9% of co-morbid group were unemployed. 80.4% of co-morbid group had family history of alcohol dependence. 41% in co-morbidity group preferred drinking alone and cited coping with stress as main reason for first drink. Major maintaining factor for alcohol dependence in co-morbidity group was to relieve negative mood (46.4%) while it was to relieve craving (56.8%) in non co-morbidity group. All alcohol dependent patients must be evaluated for co-morbid psychiatric problems. Early identification of co-morbid psychiatric disorders and incorporation of relevant interventions may reduce the morbidity, mortality and relapse in this population.