Prevalence and risk factors of intestinal protozoan and helminth infections among pulmonary tuberculosis patients without HIV infection in a rural county in P. R. China

Li, Xinxu; Chen, Jiaxu; Wang, Lixia; Tian, Li-Guang; Zhang, Yuping; Dong, Shuang-Pin; Hu, Xue-Guang; Liu, Jian; Wang, Feng-Feng; Wang, Yue; Yin, Xin; He, Lan; Yan, Qiu-ye; Zhang, Hongwei; Xu, Bingying; Zhou, Xiao‐Nong

doi:10.1016/j.actatropica.2015.05.001

Cited by 31 publications

(42 citation statements)

References 39 publications

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“…This goes in line with findings from Brazil (27.5%) [12] and Northwest Ethiopia (29%) [4]. Lower intestinal helminth co-infection rate (7%) was reported from China [11]. Elias et al (71%) [3] and Eba et al (36.8%) [18], both fromNorthwest Ethiopia, have reported higher infection rate of helminthes than that of the present study.…”

Section: Discussionsupporting

confidence: 91%

“…The co-infection rate of intestinal parasites among PTB patients in this study was 26.3% (95%CI: 20.2–32.4); higher than co-infection rate of 7.3% in China [11]. Variations in socio demographic characteristics and level of awareness about intestinal parasite transmission and prevention might be important determinants for low parasite prevalence in China as compared to the present study.…”

Section: Discussioncontrasting

confidence: 46%

“…S. stercoralis (72.7%) was with the highest prevalence in a survey from Brazil [12]. Hook worms were the most frequent helminths in China and Northwest Ethiopia with rates of 4.3% and 11.1% respectively [11, 13]. A stool survey from adult outpatient attendants in Kenya also revealed highest prevalence of hook worms (13.1%) among intestinal helminthes [22].…”

Section: Discussionmentioning

confidence: 99%

“…Strong association between active pulmonary TB (PTB) and helminthiasis has been shown from previous studies [3, 11, 12]. However the helminth species and rate of co-infection with PTB vary from place to place.…”

Section: Introductionmentioning

confidence: 96%

“…The geographical distribution of intestinal helminth infections and TB overlap substantially that co-infection in humans has been a major emerging public health problem in poorest regions of the world [3, 4, 11]. Strong association between active pulmonary TB (PTB) and helminthiasis has been shown from previous studies [3, 11, 12].…”

Section: Introductionmentioning

confidence: 99%

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Intestinal helminth co-infection and associated factors among tuberculosis patients in Arba Minch, Ethiopia

Alemu

Mama

2017

BMC Infect Dis

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BackgroundHelminths affect the outcome of tuberculosis by shifting cell mediated immune response to humoral and by total suppression of the host immune system. On the reverse, Mycobacterium infection favors immune escape of helminths. Therefore assessing helminth co-infection rate and predisposing factors in tuberculosis patients is mandatory to set strategies for better case management.MethodsFacility based cross-sectional study was conducted in Arba Minch to assess the prevalence and associated factors of intestinal helminths among pulmonary tuberculosis patients from January to August, 2016. A structured questionnaire was used to capture data about socio-demographic characteristics, clinical history and possible risk factors for intestinal helminth infections. Height and weight were measured to calculate body-mass index. Appropriate amount of stool was collected and processed by direct saline and formol-ether concentration techniques following standard protocols. All the data were analyzed using SPSS version 20.0.ResultsA total of 213 (57.3% male and 42.7% female) pulmonary tuberculosis patients were participated in the study. The overall co-infection rate of intestinal parasites was 26.3%. The infection rate of intestinal helminths account 24.4% and that of intestinal protozoa was 6.1%. Ascaris lumbricoides accounted the highest frequency of 11.3%. Living in rural residence (AOR = 3.175, 95% CI: 1.102–9.153, p = 0.032), Eating vegetables/ fruits without washing or peeling off (AOR = 2.208, 95% CI: 1.030–4.733, p = 0.042) and having body-mass index <18.5 (AOR = 3.511, 95% CI: 1.646–7.489, p = 0.001) were associated with intestinal helminth infection.ConclusionThe infection rate by intestinal helminths was 24.4%. Ascaris lumbricoides was the most prevalent helminth. Residence, habit of washing vegetables/fruits before use and body-mass index were associated factors with intestinal helminthiasis. Therefore health care providers should screen and treat TB patients for intestinal helminthiasis in order to ensure good prognosis.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Intestinal helminth co-infection and associated factors among tuberculosis patients in Arba Minch, Ethiopia

Alemu

Mama

2017

BMC Infect Dis

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Magnitude and predisposing factors of intestinal parasitosis and tuberculosis coinfection at five health institutions in Southern Ethiopia: A cross‐sectional study

Shibabaw,

Tilahun,

Gedefie

et al. 2023

Health Science Reports

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Background and AimsIntestinal parasites affect the tuberculosis disease outcome by shifting the cell‐mediated to humoral immune response and host immune system suppression. However, Mycobacterium tuberculosis (MTB) infection favors the immune escape of parasites. Hence, exploring the rate of intestinal parasitic coinfection with pulmonary tuberculosis (PTB) and its predisposing factors to take better preventive, control, and management measures.MethodsA facility‐based cross‐sectional study was conducted from September to December 2020 at five health institutions in Hawassa city. A total of 214 PTB patients were diagnosed using the GeneXpert assay and enrolled in this study. Demographic, clinical, and risk factors data were collected using a structured questionnaire. Stool samples were collected using a clean, labeled, and leak‐proof stool cup. Stool samples were examined using direct saline microscopy and the formal‐ether concentration technique. The data were entered and coded in SPSS software for analysis. Bivariate and multivariate logistic regression were employed to identify the associated risk factors. A p‐value less than 0.05 was considered statistically significant.ResultsThe overall rate of intestinal parasitic‐MTB coinfection was 36.9%. The most dominant intestinal parasite was Gardia lamblia (17.8%, 38), followed by Entamoeba histolytica/dispar (9.3%, 20). Intestinal parasitosis coinfection of PTB was associated with being rural resident (adjusted odds ratio [AOR] = 2.42; 95% confidence interval [CI]: 1.23–4.8), not washing of fruits and vegetables before eating [AOR = 4.14; 95% CI: 1.92–9], being at the early stage of anti‐TB treatment [AOR = 3; 95% CI: 1.5–6.3] and presence of chronic diseases [AOR = 7; 95% CI: 3.4–14].ConclusionThe burden of intestinal parasites‐MTB coinfection was high. Those who wash fruits and vegetables before eating should be encouraged, early treatment of PTB patients and avoiding the practice of open‐field defecation, especially in rural communities, is necessary. The dual effect of coinfection on disease severity and treatment success needs further cohort study.

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Parasitic infections in Malaysian aborigines with pulmonary tuberculosis: a comparative cross-sectional study

et al. 2019

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Prevalence and risk factors of intestinal protozoan and helminth infections among pulmonary tuberculosis patients without HIV infection in a rural county in P. R. China

Cited by 31 publications

References 39 publications

Intestinal helminth co-infection and associated factors among tuberculosis patients in Arba Minch, Ethiopia

Intestinal helminth co-infection and associated factors among tuberculosis patients in Arba Minch, Ethiopia

Magnitude and predisposing factors of intestinal parasitosis and tuberculosis coinfection at five health institutions in Southern Ethiopia: A cross‐sectional study

Parasitic infections in Malaysian aborigines with pulmonary tuberculosis: a comparative cross-sectional study

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