Prevalence and Risk Factors of Chronic Rhinosinusitis in Korea

Kim, Yoo Suk; Kim, Na Hyun; Seong, Sang Yeob; Kim, Kyung Rok; Lee, Gi-Bong; Kim, Kyung Soo

doi:10.2500/ajra.2011.25.3630

Cited by 127 publications

(83 citation statements)

References 22 publications

(36 reference statements)

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“…It is estimated that CRS affects up to 10 % of the population in the USA, with similar prevalence estimates in Europe and Asia [4–6]. Interestingly, few studies have evaluated the frequency of patients with CRSsNP compared to those who have CRSwNP in the general population.…”

Section: Epidemiologymentioning

confidence: 99%

Immune Mechanisms of Chronic Rhinosinusitis

Hulse

2015

Curr Allergy Asthma Rep

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Chronic rhinosinusitis (CRS) is a common inflammatory disease that results in a significant decrease in patient quality of life and a large economic burden. However, the lack of population-based epidemiologic studies and robust model systems has made it difficult to fully elucidate the key inflammatory pathways that drive the chronic inflammatory responses observed in CRS. This review will highlight the wide variety of factors that likely contribute to CRS disease pathogenesis. Defects in the innate immune function of the airway epithelium, including decreases in barrier function, mucociliary clearance, and production of antimicrobial peptides, all likely play a role in the initial inflammatory response. Subsequent recruitment and activation of eosinophils, mast cells, and innate lymphoid cells (ILCs) further contributes to the chronic inflammatory response and directly activates adaptive immune cells, including T and B cells. However, development of new tools and model systems is still needed to further understand the chronicity of this inflammatory response and which specific factors are necessary or sufficient to drive CRS pathogenesis. Such studies will be critical for the development of improved therapeutic strategies aimed at treating this highly prevalent and costly disease.

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Section: Epidemiologymentioning

confidence: 99%

Immune Mechanisms of Chronic Rhinosinusitis

Hulse

2015

Curr Allergy Asthma Rep

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“…in a recently published review article but are further summarized in our discussion and in Table 2. [5, 6**, 45**, 46, 47**, 48]…”

Section: Comorbid Diseases and Conditions Associated With Crsmentioning

confidence: 99%

“…[51] Other larger population-based studies have found strong associations between AR and comorbid CRS although the timing of the AR diagnosis relative to CRS onset was not elucidated (Table 2). [5, 46] In the study by Kim et al ., the aOR of having CRS among patients with moderate-severe persistent AR was 8.2 when compared to mild intermittent AR. One limitation of epidemiologic studies of AR and CRS is that the symptoms of these two conditions overlap substantially and may be difficult to differentiate using a questionnaire.…”

Section: Airway Diseasesmentioning

confidence: 99%

Risk factors for chronic rhinosinusitis

Min

Tan

2015

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review To review the recent literature on risk factors for chronic rhinosinusitis (CRS) with an emphasis on genetic, comorbid diseases and environmental factors associated with CRS. Through identifying potential risk factors for CRS, we glean insights into the underlying pathogenic mechanisms and essential for developing effective therapeutic strategies. Recent findings Recent findings demonstrate that genetics, comorbid medical conditions including airway diseases, gastroesophageal reflux disease, inflammatory and autoimmune diseases and various demographic and environmental factors are associated with having a CRS diagnosis. Limitations of current studies include, variable application of disease definitions, lack of prospective longitudinal studies and a disproportionate focus on tertiary care populations. Summary CRS has a broad spectrum of associations ranging from genetics to comorbid diseases and environmental factors. These predisposing factors provide valuable information for possible designing therapeutic and preventive interventions. However, to better understand whether these associations cause CRS, further studies are needed to independently replicate findings, establish temporal relationships between exposure and disease onset, evaluate the influence of exposure dose on disease severity, and to understand the biological effects of these risk factors in the context of CRS.

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“…Bei kritischer Analyse der Literatur lässt sich feststellen, dass eine geringe Septumdeviation [9,192] keinen Einfluss auf die Häufigkeit einer CRS besitzt, während Deviationen > 3 mm in einigen Untersuchungen mit einer erhöhten Prävalenz assoziiert sind [193,194], in anderen jedoch nicht [192,195,196]. Entsprechend kann erklärt werden, warum eine koreanische Untersuchung die Septumdeviation nicht als Risikofaktor nachgewiesen hat [9], um in einer aktuelleren Untersuchung im gleichen Land Widerspruch zu finden [98]. Nahezu gleiche Verteilungen von CRS-Patienten und Gesunden wurden für eine paradoxe Biegung des Proc.…”

Section: Sinu-nasale Anatomische Variationenunclassified

Epidemiologie der chronischen Rhinosinusitis, ausgewählter Risikofaktoren und Komorbiditäten, und ihre ökonomischen Folgen

Beule

2015

Laryngo-Rhino-Otol

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Chronic rhinosinusitis (CRS) is a relevant and prevalent medical condition in Germany, Europe and the world. If analysed in detail, the prevalence of CRS shows regional and temporary variety. In this review, currently available data regarding the prevalence of CRS is therefore sorted by country and/or region, time point of data collection and the CRS-definition employed. Risk factors like smoking and gastro-oesophageal reflux are discussed regarding their influence on CRS prevalence. Moreover, co-morbidities of CRS, like asthma, conditions of the cardiovascular system and depression are listed and their influence on CRS is discussed. Furthermore, data on CRS prevalence in special cohorts, like immunocompromised patients, are presented. To estimate the economic burden of CRS, current data e.g. from Germany and the USA are included in this review.

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Prevalence and Risk Factors of Chronic Rhinosinusitis in Korea

Abstract: Although the prevalence and risk factors vary according to time, place, and diagnostic criteria, periodic epidemiological study on CRS is necessary to reduce socioeconomic expenditure and establish an improved national health care policy.

Cited by 127 publications

References 22 publications

Immune Mechanisms of Chronic Rhinosinusitis

Immune Mechanisms of Chronic Rhinosinusitis

Risk factors for chronic rhinosinusitis

Epidemiologie der chronischen Rhinosinusitis, ausgewählter Risikofaktoren und Komorbiditäten, und ihre ökonomischen Folgen

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