Prevalence and risk factors of hepatocellular carcinoma in Japanese patients with primary biliary cirrhosis

Abstract

Primary biliary cirrhosis (PBC) tends to affect females more than males. PBC selectively damages intrahepatic small bile ducts, particularly interlobular bile ducts. The clinical presentation of PBC has changed according to recent advances in clinicobiological diagnosis and improvements in therapeutic effects and prognosis. In particular, we encounter PBC patients with hepatocellular carcinoma (HCC), and the number of these patients appears to have increased. The precise reason for the increased number of PBC patients with HCC in recent decades remains unknown, but recognizing the current status of carcinogenesis in PBC patients, identifying the associated clinicopathological risk factors and understanding how the pathogenesis of PBC is directly associated with HCC, is important. In this review, we summarize the data from two nationwide surveys undertaken in Japan as well as recent data from Japanese and international studies.

Clinical Characteristics of Concomitant Systemic Lupus Erythematosus and Primary Biliary Cirrhosis: A Literature Review

“…Floreani et al [ 61 ] reported that the prevalence of HCC in patients with PBC was 3.0% (11/361) after a mean follow-up period of 8 ± 6.9 years. According to Harada and Nakanuma [ 10 ], the incidence of HCC in patients with PBC has increased over the recent decades in Japan. The development of HCC may be associated with refractory to UDCA [ 58 ].…”

Liver Complications Associated with Systemic Lupus Erythematosus

“…It is described as an organ-specific disturbance characterized by chronic progressive cholestasis that destroys the intrahepatic small bile ducts, particularly the interlobular bile ducts [30][31][32][33][34]. Pertaining to the histopathological aspects of PBC, the findings in florid bile duct lesions such as chronic, nonsuppurative destructive cholangitis and epithelioid granuloma formation are established and useful for diagnosing PBC [34].…”

Concomitant Case of Primary Biliary Cirrhosis and Autoimmune Hemolityc Anemia Responding to Corticosteroid and Ursodeoxycholic Acid in Young Woman

“…1,2,3 The disease is uncommon, with a reported prevalence between 19 and 402 cases per million. The vast majority (90%) of patients affected are women, with the usual time of diagnosis between 30 and 60 years.…”