Prevalence and risk factors of human papillomavirus infection by penile site in uncircumcised Kenyan men

Smith, Jennifer S.; Backes, Danielle M.; Hudgens, Michael G.; Bailey, Robert C.; Veronesi, Giovanni; Bogaarts, Martijn; Agot, Kawango; Ndinya‐Achola, Jeckoniah; Maclean, Ian; Agingu, Walter; Meijer, Chris J.L.M.; Moses, Stephen; Snijders, Peter J.F.

doi:10.1002/ijc.24770

Cited by 40 publications

(61 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genital warts in children are infrequent while penile warts are even rarer [1][2][3][4][5]. The youngest documented case of this type was a 7-month-old circumcised Caucasian boy presented with a rapidly progressing giant penile condyloma acuminatum that was surgically removed followed by a fatal course of Neisseria meningitis.…”

Section: Introductionmentioning

confidence: 99%

HPV6 Infection of an Infant’s Penile Condyloma at the Urethral Meatus

A¹

2013

J Genet Syndr Gene Ther

View full text Add to dashboard Cite

Penile warts in infants are rare and condylomata acuminata at the urethral meatus are rarer. This is a first report of a 2.5 years infant with a condyloma acuminatum at the urethral meatus of penis that was found positive for HPV 6, by PCR analysis. Infant's mother presented warts on her hands, suggesting a possible transmission of virus from mother to infant via extragenital contact, without excluding a vertical transmission.

show abstract

Section: Introductionmentioning

confidence: 99%

HPV6 Infection of an Infant’s Penile Condyloma at the Urethral Meatus

A¹

2013

J Genet Syndr Gene Ther

View full text Add to dashboard Cite

show abstract

“…A study among Kenyan fishermen showed a lower risk for HPV infection in older age groups, [10] while data from Kenyan men participating in an MC trial showed little variation in prevalence with age. [28] A more recent study in men from Tanzania demonstrated an association between increasing age and HPV prevalence, but that this association was driven by HIVpositive men. [15] Two recent incidence studies confirmed that increasing age is associated with a lower risk for HPV infection.…”

Section: Factors Associated With Hpv Infectionmentioning

confidence: 99%

“…Similar observations about sexual risk behaviour and an association with HPV have been made in studies of men in SSA. [10,17,28] While the data on the protective effects of condoms are somewhat mixed, [35] evidence from African studies in men show a reduced risk of genital HPV infection associated with condom use. [10,28,36,37] Evidence from randomised controlled trials (RCTs) of MC has conclusively demonstrated the protective benefits of MC in reducing the risk of HPV prevalence and incidence.…”

Section: Factors Associated With Hpv Infectionmentioning

confidence: 99%

“…[10,17,28] While the data on the protective effects of condoms are somewhat mixed, [35] evidence from African studies in men show a reduced risk of genital HPV infection associated with condom use. [10,28,36,37] Evidence from randomised controlled trials (RCTs) of MC has conclusively demonstrated the protective benefits of MC in reducing the risk of HPV prevalence and incidence. [17,36,38,39] Related findings from the trial in Kenya have highlighted less frequent bathing as a risk factor for HPV infection, which may be associated with poor genital hygiene in uncircumcised men.…”

Section: Factors Associated With Hpv Infectionmentioning

confidence: 99%

“…[17,36,38,39] Related findings from the trial in Kenya have highlighted less frequent bathing as a risk factor for HPV infection, which may be associated with poor genital hygiene in uncircumcised men. [18,28] STIs are independently associated with the risk of HPV infection, particularly chlamydia, [19,30] herpes simplex virus (HSV)-2, [34] and hepatitis B. [40] While they may share a common mode of transmission, STIs are thought to increase the risk of HPV infection by facilitating access to the basal epithelium through micro-abrasions in the skin.…”

Section: Factors Associated With Hpv Infectionmentioning

confidence: 99%

See 2 more Smart Citations

Human papillomavirus infection and disease in men: Impact of HIV

Delany‐Moretlwe

Chikandiwa

Gibbs

2013

South. Afr. j. HIV med.

View full text Add to dashboard Cite

There is growing evidence of a significant burden of human papillomavirus (HPV) infection and associated disease in men. High rates of HPV infection have been observed in men from sub-Saharan Africa where HIV prevalence is high. HIV infection increases HPV prevalence, incidence and persistence and is strongly associated with the development of anogenital warts and anal, penile and head and neck cancers in men. Despite increasing access to antiretroviral therapy, there appears to be little benefit in preventing the development of these cancers in HIV-positive men, making prevention of infection a priority. New prevention options that are being introduced in many African countries include male circumcision and HPV vaccination. However, more data are needed on the burden of HPV disease in men before boys are included in HPV vaccination programmes. Human papillomavirus (HPV) is a common sexually transmitted infection (STI) affecting both men and women. S Afr J HIV Med[1] HPV infections can be classified as either low-(LR) or high-risk (HR).[2]HR-HPV infections have been associated with cancer of the anogenital and oropharyngeal tissues. While the majority of HPV infections are transient and clear spontaneously, persistent infection with HR-HPV is associated with the development of pre-neoplastic and neoplastic lesions in these areas (Fig. 1). While much is known about the natural history of HPV infection in cervical cancer in women, less is known about the development of HPV-associated disease in men. Emerging evidence points to a significant role for HIV infection in promoting HPV prevalence, incidence and persistence. This review provides an update on current evidence regarding the epidemiology of HPV infection and disease in men, the effects of HIV on HPV infection and disease in men in sub-Saharan Africa (SSA), and the prospects for prevention in this setting. Global burden of HPVHPV infection is ubiquitous in men. A systematic review of 62 studies using reliable methods of HPV DNA detection and conducted prior to 2009, representing 14 800 men in 23 countries, showed that anogenital HPV DNA prevalence is generally high in sexually active men. The review highlighted considerable variation in estimates by region, from 1% to 84% in LR men, to 2% to 93% in HR men. [3] Compared with studies in women, peak prevalence spanned a wide range of ages, suggesting that men have the potential for longer-term persistence of infection or higher rates of re-infection.[3] Typespecific HPV seroprevalence studies are better indicators of lifetime exposure to HPV infection, although they may underestimate cumulative HPV exposure, given that not all infections lead to seroconversion.[4] Recent population-based studies have estimated the prevalence of antibodies to vaccinepreventable HPV types 6, 11, 16 and 18. Among men aged 14 -59 years in the USA, 12.2% of men were seropositive for any vaccine type, with a peak prevalence of 18% among men aged 50 -59 years.[5] In a similar population-based study in Australia, peak prevalence of any...

show abstract

Male circumcision and anatomic sites of penile high‐risk human papillomavirus in Rakai, Uganda

Tobian

Kong

Gravitt

et al. 2011

Intl Journal of Cancer

View full text Add to dashboard Cite

Male circumcision (MC) reduces penile high-risk human papillomavirus (HR-HPV) on the coronal sulcus and urethra. HR-HPV varies by anatomic site, and it is unknown whether MC decreases HR-HPV on the penile shaft. We assessed the efficacy of MC to reduce HR-HPV on the penile shaft and compared it to known efficacy of MC to reduce HR-HPV on the coronal sulcus. HIV-negative men randomized to receive immediate circumcision (intervention) or circumcision delayed for 24 months (control) were evaluated for HR-HPV at 12 months post-enrollment using the Roche HPV Linear Array assay. Among swabs with detectable beta-globin or HPV, year 1 HR-HPV prevalence on the coronal sulcus was 21.5% in the intervention arm and 36.3% in the control arm men (adjusted prevalence risk ratios (PRR)=0.57, 95%CI 0.39–0.84, p=0.005). On the shaft, year 1 HR-HPV prevalence was 15.5% in the intervention and 23.8% in the control arm (adjusted PRR=0.66, 95%CI 0.39–1.12, p=0.12). Efficacy of MC to reduce HR-HPV on the shaft was similar to efficacy on the coronal sulcus (p=0.52). In a sensitivity analysis in which swabs without detectable beta-globin or HPV were included as HPV negative, prevalence of HR-HPV on the shaft was lower in the intervention arm (7.8%) than control arm (13.6%) (PRR 0.57, 95%CI 0.33–0.99, p<0.05). HR-HPV was more frequently detected on the coronal sulcus than penile shaft among uncircumcised men (36.3% vs 23.8%, respectively, p=0.02) and circumcised men (21.5% vs 15.5%, respectively, p=0.24). MC reduced HR-HPV prevalence on both the coronal sulcus and shaft.

show abstract

Prevalence and risk factors of human papillomavirus infection by penile site in uncircumcised Kenyan men

Cited by 40 publications

References 14 publications

HPV6 Infection of an Infant’s Penile Condyloma at the Urethral Meatus

HPV6 Infection of an Infant’s Penile Condyloma at the Urethral Meatus

Human papillomavirus infection and disease in men: Impact of HIV

Male circumcision and anatomic sites of penile high‐risk human papillomavirus in Rakai, Uganda

Contact Info

Product

Resources

About