Prevalence and risk factors of erosive esophagitis in Taiwan

Ou, Jianlin; Tu, Chin-Chih; Hsu, Ping‐I; Pan, Min‐Hsiung; Lee, Chung-Cheng; Tsay, Feng‐Woei; Wang, Huay-Min; Cheng, Linyin; Lai, Kwok‐Hung; Yu, Hsien‐Chung

doi:10.1016/j.jcma.2011.12.008

Cited by 23 publications

(19 citation statements)

References 31 publications

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“…Recent data have shown that long-term use of LES relaxing medications, such as theophylline, is associated with EAC [55]. However, the epidemiological studies investigating the effects of tea on GERD are scant and the results are conflicting [6,15,29,56–61], possibly because of difficulty in assessing the quantity and the quality of tea in a population-based study. Many culturally-related drinking habits, such as the consumption of black tea, green tea and strong tea [56], along with drinking tea at hot temperatures [62], and adding nutrients such as cream or sugar [49], may contribute differently to the reflux or irritation of esophageal mucosa.…”

Section: Discussionmentioning

confidence: 99%

Alcohol and tea consumption are associated with asymptomatic erosive esophagitis in Taiwanese men

Chang¹,

Wu²,

Wang³

et al. 2017

PLoS ONE

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ObjectiveAsymptomatic erosive esophagitis (AEE) is commonly found in men, and might be a risk factor of developing esophageal adenocarcinoma. We aimed to determine if specific dietary habits increase the risk of AEE in asymptomatic Taiwanese men.MethodsWe recruited male adults undergoing upper gastrointestinal endoscopy for health check. We excluded subjects with reflux symptoms, or taking anti-reflux medications or drugs that potentially impair lower esophageal sphincter function or cause mucosal injury. The frequency of consuming reflux-provoking diets including alcohol, tea, coffee, tomato/citric juice, chocolate, sweet food, and spicy food was assessed. The erosive esophagitis was diagnosed based on the Los Angeles Classification after endoscopy. Frequent consumption of a specific diet was defined as ≥4 days/week of consuming that diet.ResultsA total of 1256 participants were recruited. After excluding 424 ineligible subjects, AEE was identified in 180 (22%) among 832 asymptomatic subjects. The risk of AEE increased with the number of days per week of consuming alcohol or tea: nondrinkers (19%, 17%), occasional drinkers (<1 day/week; 19%, 15%), regular drinkers (1–3 days/week; 26%, 21%), frequent drinkers (4–6 days/week; 32%, 22%), and daily drinkers (42%, 28%), respectively (trend test P < 0.001 for both). Multivariate analysis showed that hiatus hernia (adjusted odds ratio (aOR) 5.0, 95% confidence interval (CI) 2.6–9.6), drinking alcohol ≥4 days/week (aOR 2.3, 95% CI 1.3–4.0), and drinking tea ≥4 days/week (aOR 1.6, 95% CI 1.1–2.3) are independent risk factors of AEE. The risk of AEE was 3.8 times greater for those drinking both alcohol and tea ≥4 days/week than the non-drinkers.ConclusionsFrequent alcohol and tea consumption increased the risk of AEE in Taiwanese men.

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Section: Discussionmentioning

confidence: 99%

Alcohol and tea consumption are associated with asymptomatic erosive esophagitis in Taiwanese men

Chang¹,

Wu²,

Wang³

et al. 2017

PLoS ONE

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“…Endoscopy-diagnosed erosive esophagitis has been increasing in Asia over 2 decades, with a reported prevalence of 3.3 to 8.5% in Korea, China and Japan except Taiwan (ranging from 17.3 to 18.3%) which is similar to other Western developed countries 1-6. The reasons for the high prevalence rate of erosive esophagitis are not clearly demonstrated, however, it could be related with western diet, increased obesity and aging of population 6.…”

Section: Introductionmentioning

confidence: 90%

“…The reasons for the high prevalence rate of erosive esophagitis are not clearly demonstrated, however, it could be related with western diet, increased obesity and aging of population 6. The prevalence rate of erosive esophagitis was 8%, in prospective nationwide multicentre studies of 25,536 health check-up Koreans 7.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Erosive Esophagitis Is Not Significantly Increased in a Healthy Korean Population - Could It Be Explained?: A Multi-center Prospective Study

Seo

Jeon

Chung

et al. 2013

J Neurogastroenterol Motil

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Background/AimsResearches on the potential risk factors for the development of erosive esophagitis have been conducted extensively, however, the results are conflicting. The aim of this multicenter study was to identify the prevalence rate and risk factors of erosive esophagitis and their interactions with residency status.MethodsA total of 4,023 eligible subjects at 8 tertiary health care centers were evaluated using questionnaires, laboratory tests and endoscopy. Univariate and multivariate analyses were conducted to identify independent risk factors for erosive esophagitis.ResultsThe prevalence rate of reflux esophagitis was 8.8%. Los Angeles grade A was common type of erosive esophagitis. Residence in a large urban areas was negatively associated with the development of erosive esophagitis (OR, 0.60; 95% CI, 0.40-0.90). The high body mass index (≥ 25 kg/m2) was more frequent in residents of small and medium-sized cities than those in big cities (38.8% and 26.9%, respectively; P < 0.001). Seronegativity of Helicobacter pylori was associated with increased erosive esophagitis (OR, 1.91; 95% CI, 1.48-2.46). Triglyceride ≥ 150 mg/dL (OR, 1.65; 95% CI, 1.08-2.07), fasting glucose level ≥ 126 mg/dL (OR, 1.73; 95% CI, 1.06-2.81), and hiatal hernia (OR, 3.11; 95% CI, 1.87-5.16) were also associated with erosive esophagitis.ConclusionsThe prevalence rate of erosive esophagitis and its risk factors in this study were similar to the result of 8.0% of nationwide study in 2006. Residency and obesity are more important independent risk factors than H. pylori infection status for development of erosive esophagitis in Korea. These results suggest that the prevalence rate of erosive esophagitis in Korea might not increase as in the Western countries.

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“…4 Regarding the risk factors leading to GERD, the authors also indicated that male gender, smoking, increased body mass index, and hiatal hernia were independent risk factors among the enrolled subjects. 7 However, these reported GERD risk factors are not new in Taiwan because the literature already indicates that male gender, 2,8,12 old age, 12 hiatal hernia, 2,8 smoking, 5,9,12 alcohol consumption, 9,12 metabolic syndrome, 9,12 high fasting blood glucose level, 12 high blood pressure, 12 obesity, 2,5,12 and chronic obstructive pulmonary disease 8 are well-known confounding factors that can lead to GERD, including EE. The authors are just confirming the known GERD risk factors again.…”

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confidence: 99%

Variations in the reported prevalence of gastroesophageal reflux disease in Taiwan

Chang

2012

Journal of the Chinese Medical Association

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Prevalence and risk factors of erosive esophagitis in Taiwan

Abstract: The current prevalence of erosive esophagitis in Taiwan is 17.3%. Male sex, smoking, obesity, and hiatus hernia are four independent risk factors for the development of erosive esophagitis in the Taiwanese population.

Cited by 23 publications

References 31 publications

Alcohol and tea consumption are associated with asymptomatic erosive esophagitis in Taiwanese men

Alcohol and tea consumption are associated with asymptomatic erosive esophagitis in Taiwanese men

The Prevalence of Erosive Esophagitis Is Not Significantly Increased in a Healthy Korean Population - Could It Be Explained?: A Multi-center Prospective Study

Variations in the reported prevalence of gastroesophageal reflux disease in Taiwan

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