Prevalence and risk factors of microalbuminuria in type 2 diabetes mellitus

Mohan, Mane Madan; Sekhar, Chandra

doi:10.18203/2349-3933.ijam20151014

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…In line with these results, Mehrotra et al (13) stated that patients with DN had a longer duration of DM in comparison to those without renal impairment. Also, Mohan and Sekhar (14) have reported the same findings. But other studies stated that the duration of DM had a nonsignificant association with renal impairment (15)(16)(17) .…”

Section: Discussionsupporting

confidence: 61%

Plasma Concentration of Osteopontin as A Predictor of Vascular Calcification in Patients with Diabetic Nephropathy

Azoz¹,

Sobh²,

Ahmed

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Vascular calcification (VC) is a common health problem in patients with diabetic nephropathy (DN). Early recognition of vascular calcification has a great effect on the outcome. Objective: We aimed to assess the efficacy of serum osteopontin (OPN) in the early prediction of VC in patients with diabetic nephropathy. Patients and Methods: A total of 70 patients with type 2 diabetes mellitus were divided into equal two groups. Group (A): included 35 patients with diabetic nephropathy with chronic kidney disease (CKD) stage I-IV and group (B): included 35 patients with DN with CKD stage V on hemodialysis. Another 30 healthy subjects were recruited as a control group. Carotid Doppler and echocardiography were done in patients' groups only while serum OPN was measured in all groups. Results: Osteopontin was found to be higher in group B in comparison to other groups and also higher in group A in comparison control group. A total of 31 (44.3%) patients had VC. Patients with VC had higher OPN in comparison to those without VC. Predictors for VC in patients with CKD were OPN, intima thickness and CKD stage V. OPN at cutoff point > 144 ng/ml had 93% overall accuracy for the prediction of VC in patients with CKD, and the area under the curve was 0.966. Conclusion:We concluded that (1) OPN level was significantly higher in hemodialysis patients with diabetic nephropathy stages V than those diabetic patients with chronic kidney disease stage I-IV. (2) OPN level was significantly higher in patients with vascular calcification than in those without. So, OPN can be used as an early marker for the detection of vascular calcification.

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Section: Discussionsupporting

confidence: 61%

Plasma Concentration of Osteopontin as A Predictor of Vascular Calcification in Patients with Diabetic Nephropathy

Azoz¹,

Sobh²,

Ahmed

et al. 2022

The Egyptian Journal of Hospital Medicine

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“…Hyperperfusuion to the glomerulus and hypertrophy of the renal calyces occurs in initial phase after onset of diabetes mellitus, which is reflected by increase in glomerular filtration rate (GFR). [6][7][8] Screening of microalbumin can be done using quantitative methods including measurement of albumin to creatinine ratios in random sample of urine, 24 -hour collection with creatinine, which allows the simultaneous measurement of creatinine clearance, timed (e.g. 4 hourly) overnight collection of urine for protein, or it can be measured using semi -quantitative reagent dipsticks.…”

Section: Introductionmentioning

confidence: 99%

Microalbuminuria and its association with glycemic control in patients with diabetes mellitus type II.

Jiskani¹,

Singh²,

Meghji³

et al. 2020

TPMJ

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Diabetes mellitus is chronic condition with defect in regulation of insulin. Microalbuminuria is one of the early appearing markers of overt diabetic nephropathy. Uncontrolled glycemic status has been postulated to be associated with increase urinary albumin levels. Objectives: To find out the association of increased urinary albumin with poor glyemic status of patients with diabetes mellitus type II. Study Design: Cross Sectional study. Setting: Department of Pathology, Indus Medical College Hospital Tando Muhammad Khan. Period: November 2018 to June 2019. Material & Methods: Patients were divided into two groups: Group I (Poor glycemic control, HbA1c >7%) and Group II (Good glycemic control, HbA1c <7%). Glycated hemoglobin and microalbuminuria were evaluated in all patients. Data was analyzed using SPSS 21.0. P – value of <0.05 was considered as statistically significant. Results: Total of 213 patients were included in the study with male ratio (56.8%) slightly higher than females (43.19%). Mean age of patients was 42.3 ± 2.1 years. Mean glycated hemoglobin in Group I and II was 8.12 ± 0.97% and 5.98 ± 0.41% respectively. In Group I, 57.54% patients were detected with microalbuminuria as compared to Group II (12.26%). P value was statistically significant (<0.001). Conclusion: Microalbuminuria was found more frequently in patients with poor glycemic control. Early detection of urinary microalbumin in these patients may decrease the risk of kidney damage and appropriate and adequate management in initial stage.

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Determinants of poor glycaemic control and proteinuria in patients with type 2 diabetes: a retrospective analysis of general practice records in Ireland

Sullivan,

O’Connor,

Hannigan

2024

BMC Prim. Care

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Background Analysis of general practice records can address the information gap on the epidemiology of type 2 diabetes (T2DM) in Ireland, informing practice and the development of interventions in primary care. The aim of this study was to identify patients with poor glycaemic control, risk factors for complications and evidence of end organ damage in a large multi-practice study and to profile their characteristics. Methods Patients with T2DM were identified using disease coding in Health One practice management software in 41 general practices. Patients’ demographics and clinical data were extracted. Rates of poor glycaemic control (glycated haemoglobin > 58 mmol/mol) and albumin creatinine ratio > 3 mg/mmol were calculated. A multilevel logistic regression analysis using both patient and practice variables was conducted. Results Data was collected from 3188 patients of whom 29% (95% CI 28 to 31%) had poor glycaemic control, which was associated with younger age, higher BMI and higher total cholesterol. Only 42% of patients (n = 1332) had albumin creatinine ratio measured with 42% (95% CI 40 to 45%) of these having values > 3 mg/mmol. Older age groups, men, those with hypertension, eGFR < 60 ml/min/1.73m2 and poor glycaemic control were most associated with higher values of albumin creatinine ratio. Conclusions Analysing this large multi-practice dataset gives important information on the prevalence and characteristics of diabetic patients who are most at risk of poor outcomes. It highlights that recording of some data could be improved.

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Prevalence and risk factors of microalbuminuria in type 2 diabetes mellitus

Cited by 4 publications

References 15 publications

Plasma Concentration of Osteopontin as A Predictor of Vascular Calcification in Patients with Diabetic Nephropathy

Plasma Concentration of Osteopontin as A Predictor of Vascular Calcification in Patients with Diabetic Nephropathy

Microalbuminuria and its association with glycemic control in patients with diabetes mellitus type II.

Determinants of poor glycaemic control and proteinuria in patients with type 2 diabetes: a retrospective analysis of general practice records in Ireland

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