Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children

El-Raziky, M. S.

doi:10.3748/wjg.v13.i12.1828

Cited by 55 publications

(46 citation statements)

References 24 publications

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“…The current study shows significantly higher levels of AFP in patients with HCC than other patients and controls ,this finding came in agreement with the work of many authors(El-Lyra et al,2004) and (Raziky et al 2007). Based on this significant higher level, an attempt was done to evaluate AFP in diagnosis of HCC using ROC curve analysis (Ciesla et al, 2012).…”

Section: Results:-supporting

confidence: 94%

DETECTION OF IL-28 rs 12979860 GENE POLYMORPHISM BY REAL TIME PCR IN HEPATOCELLULAR CARCINOMA PATIENTS.

Mohamed¹,

Badawy²,

Elagawy³

et al. 2016

IJAR

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Section: Results:-supporting

confidence: 94%

DETECTION OF IL-28 rs 12979860 GENE POLYMORPHISM BY REAL TIME PCR IN HEPATOCELLULAR CARCINOMA PATIENTS.

Mohamed¹,

Badawy²,

Elagawy³

et al. 2016

IJAR

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“…However, in a study carried out in the Hepatology Unit, Cairo University in which 1042 children were screened, asymptomatic HCV infection was detected in 2%. None of these children were positive for HIV [20]. Blood transfusion was a major risk factor among 77% of HCV patients.…”

Section: Discussionmentioning

confidence: 94%

Major risk of blood transfusion in hemolytic anemia patients

Omar

Salama

Adolf³

et al. 2011

Blood Coagulation &Amp; Fibrinolysis

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Thalassemia is a congenital hemolytic disease caused by defective globin synthesis treated by blood transfusion. Transfusion-transmitted infections still make a great challenge in the management of patients with thalassemia major. The most important worldwide transfusion-transmitted infections are hepatitis B virus (HBV), hepatitis C virus (HCV) and HIV. The objective of this study is to update the prevalence of the three major transfusion-transmitted infections HCV, HBV and HIV among thalassemic patients followed up in the Hematology Department, Children Hospital, Cairo University. The study included 174 multitransfused thalassemic patients (162 major and 12 intermedia), registered at the Pediatric Hematology Clinic, Cairo University. Their age ranged from 2 to 27 years with a mean of 11.26 ± 5.4 years. Patients were subjected to full history taking, stressing on history of blood transfusions (onset, frequency and duration) at a single or multiple centers and abdominal examination. Laboratory investigations including complete blood count, aminotransferases (aspartate aminotransferase and alanine aminotransferase), ferritin and viral markers of HBV surface antigen (HBsAg), HCV antibodies (anti-HCV) and anti-HIV were assayed for all cases by a third-generation ELISA method. HCV PCR was performed for 75 cases. Of the 174 patients, none of them were HBsAg and anti-HIV positive. However, 90 patients were anti-HCV positive (51.7%). HCV PCR was positive in 56 patients (74.3%) of the 75 with positive antibody tested. HCV antibody positivity is statistically significant with age of the patient, serum ferritin and liver transaminases (P < 0.01). HCV-RNA by PCR positivity was significantly related to patients' age and serum ferritin (P < 0.05). Serum ferritin showed statistically significant positive correlation with liver transaminases. Despite the decrease in prevalence of HCV antibody in our patients from 71% in 1995 to 51.7% in our study, yet HCV infection still represents a major health problem for our thalassemic patients, which requires more attention and efforts to challenge. There is a dramatic decrease in the prevalence of HBV infection over the last decade, thanks to mass compulsory vaccination and blood screening. HIV infection does not represent a problem owing to very low population prevalence.

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“…Regarding the parenteral spread by the previous use of intravenous anti-schistosomal treatment campaigns, HCV prevalence is very high in Egypt, particularly in the age group of 40-60 years [54][55][56] . A high prevalence of HCV among children born after these campaigns is explained by unsafe injections [54][55][56] . In Pakistan, the prevalence of HCV is variable from 2% to 14%, and HCV transmission in this region is due to unsafe injections [57] .…”

Section: Chronic Hepatitis Cmentioning

confidence: 99%

Epidemiology and viral risk factors for hepatocellular carcinoma in the Eastern Mediterranean countries

Yapalı¹,

Tözün²

2018

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Given the high prevalence of viral hepatitis in the Eastern Mediterranean countries, hepatitis B and C infections are the major causes of hepatocellular carcinoma (HCC) in the region. Most cases are associated with cirrhosis related to hepatitis B or C infection. Environmental, host genetic and viral factors can affect the risk of HCC in patients with hepatitis B and C infection. Understanding the epidemiology and viral risk factors in the region provides the implementation of strategies for prevention and treatment of viral hepatitis. Herein, we reviewed the epidemiology, burden of disease and viral risk factors for HCC.

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Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children

Cited by 55 publications

References 24 publications

DETECTION OF IL-28 rs 12979860 GENE POLYMORPHISM BY REAL TIME PCR IN HEPATOCELLULAR CARCINOMA PATIENTS.

DETECTION OF IL-28 rs 12979860 GENE POLYMORPHISM BY REAL TIME PCR IN HEPATOCELLULAR CARCINOMA PATIENTS.

Major risk of blood transfusion in hemolytic anemia patients

Epidemiology and viral risk factors for hepatocellular carcinoma in the Eastern Mediterranean countries

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