Prevalence and Risk Factors of Comorbid Obesity in Chinese Patients with Bipolar Disorder

Abstract

Purpose Bipolar disorder (BD) predisposes patients to comorbid obesity and increases the risk of metabolic syndrome and cardiovascular disease. In this study, we investigated the prevalence of comorbid obesity and its risk factors in patients with BD in China. Patients and Methods We conducted a cross-sectional retrospective survey of 642 patients with BD. Demographic data were collected, physical examinations were performed, and biochemical indexes, including fasting blood glucose, alanine aminotransferase (ALT), aspartate aminotransferase, and triglycerides (TG) levels, were measured. Height and weight were measured on an electronic scale at admission, and body mass index (BMI) was in kg/m 2 . Pearson’s correlation analysis was used to analyze the correlation between BMI and variable indicators. Multiple linear regression analysis was used to analyze the risk factors for comorbid obesity in patients with BD. Results The prevalence of comorbid obesity in Chinese patients with BD was 21.3%. Obese patients had high levels of blood glucose, ALT, glutamyl transferase, cholesterol, apolipoprotein B (Apo B), TG, and uric acid in the plasma; however, the levels of high-density lipoprotein and apolipoprotein A1 were lower than those in non-obese patients. Partial correlation analysis showed that BMI was associated with ApoB, TG, uric acid, blood glucose, GGT, TC, ApoA1, HDL, and ALT levels. Multiple linear regression showed that ALT, blood glucose, uric acid, TG, and Apo B levels were important risk factors of BMI. Conclusion The prevalence of obesity is higher in patients with BD in China, and TG, blood glucose, liver enzymes, and uric acid are closely related to obesity. Therefore, more attention should be paid to patients with comorbid obesity. Patients should be encouraged to increase their physical activity, control sugar and fat intake, and reduce the prevalence of comorbid obesity and risk of serious complications.

Sex-Based Differences and Risk Factors for Comorbid Nonalcoholic Fatty Liver Disease in Patients with Bipolar Disorder: A Cross-Sectional Retrospective Study

“…Existing studies have shown sex differences in the duration and type of attacks in male and female patients with BD, 26 but little is known about the presence of comorbid NAFLD, making it particularly important to investigate risk factors for comorbid NAFLD in different sexes. Our previous study find significantly higher rates of comorbid obesity in patients with BD and higher plasma levels of ALT, blood glucose, uric acid and TG in obese patients; 7 building on this finding, we take it a step further to examine sex differences in comorbid NAFLD in patients with BD, targeting sex-specific risk factors.…”

The Prevalence of Hyperuricemia and the Association Between Hyperuricemia and Age in Patients with Psychiatric Disorders to a General Hospital: A Cross-Section Study

“… 58 , 59 The most explicit thing was the use of antipsychotics, especially atypical antipsychotics. 60 The metabolic side effects of antipsychotic drugs in the clinical population are now well established. 61 Norepinephrine, epinephrine and catecholamine are hormones that are very important in the regulation of many metabolic processes.…”

Identification of the role of immune-related genes in the diagnosis of bipolar disorder with metabolic syndrome through machine learning and comprehensive bioinformatics analysis

“…As is widely known, mental disorders, including BD, can influence a range of metabolic changes such as blood lipids. In our extensive literature review, we found that most studies have focused on the impact of BD on MS (13)(14)(15).…”