Prevalence and Risk Factors of Sarcopenia in Patients With Diabetes: A Meta-analysis

Feng, Luo; Gao, Qianqian; Hu, Kaiyan; Wu, Mei; Wang, Zhe; Chen, Fei; Fan, Ming; Zhao, Li; Ma, Bin

doi:10.1210/clinem/dgab884

Cited by 89 publications

(69 citation statements)

References 48 publications

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“…However, protein restriction may inhibit hepatic albumin synthesis [ 138 ], which might be further suppressed by inflammatory signals [ 139 ], characterizing DN [ 140 ]. Furthermore, diabetes [ 141 ] as well as CKD [ 142 ] are associated with sarcopenia, and the likelihood of sarcopenia among diabetics increases 2.54-fold in the presence of DN [ 141 ]. Renal protein wasting, discussed above, possibly contributes to sarcopenia, and intuitively one would favor enriched protein intake rather than a low-protein diet specifically in this population.…”

Section: Clinical Perspectivesmentioning

confidence: 99%

Diabetic Proteinuria Revisited: Updated Physiologic Perspectives

Heyman

Dwyer

Sibony

et al. 2022

Cells

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Albuminuria, a hallmark of diabetic nephropathy, reflects not only injury and dysfunction of the filtration apparatus, but is also affected by altered glomerular hemodynamics and hyperfiltration, as well as by the inability of renal tubular cells to fully retrieve filtered albumin. Albuminuria further plays a role in the progression of diabetic nephropathy, and the suppression of glomerular albumin leak is a key factor in its prevention. Although microalbuminuria is a classic manifestation of diabetic nephropathy, often progressing to macroalbuminuria or overt proteinuria over time, it does not always precede renal function loss in diabetes. The various components leading to diabetic albuminuria and their associations are herein reviewed, and the physiologic rationale and efficacy of therapeutic interventions that reduce glomerular hyperfiltration and proteinuria are discussed. With these perspectives, we propose that these measures should be initiated early, before microalbuminuria develops, as substantial renal injury may already be present in the absence of proteinuria. We further advocate that the inhibition of the renin–angiotensin axis or of sodium–glucose co-transport likely permits the administration of a normal recommended or even high-protein diet, highly desirable for sarcopenic diabetic patients.

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Section: Clinical Perspectivesmentioning

confidence: 99%

Diabetic Proteinuria Revisited: Updated Physiologic Perspectives

Heyman

Dwyer

Sibony

et al. 2022

Cells

View full text Add to dashboard Cite

show abstract

“…In fact, type 2 diabetes has been identified as a risk factor for sarcopenia 3 . Because body mass index (BMI) of patients with diabetes mellitus in Asian countries is much lower than in other countries 4 and low BMI is a strong predictor of sarcopenia, 5 sarcopenia easily develops in elderly Asians with diabetes 6 …”

Section: Introductionmentioning

confidence: 99%

Prediabetes is an independent risk factor for sarcopenia in older men, but not in older women: the Bunkyo Health Study

Tamura

Someya

Naito

et al. 2022

J cachexia sarcopenia muscle

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Background Sarcopenia is a major cause of disability in the elderly. Although type 2 diabetes is a risk factor for increased sarcopenia, the relationship between prediabetes and sarcopenia has not been elucidated. We aimed to examine the relationship between sarcopenia and prediabetes. Methods The design of this study is a cross‐sectional study. We evaluated glucose metabolism using the 75‐g oral glucose tolerance test and glycated haemoglobin, appendicular skeletal muscle mass, and hand grip strength in 1629 older adults living in an urban area of Tokyo, Japan. We investigated the frequency of sarcopenia in participants with normal glucose tolerance (NGT), prediabetes and diabetes. A multivariable logistic regression model was used to analyse the association between glucose tolerance and the prevalence of sarcopenia. Results The mean age of participants was 73.1 ± 5.4 years. In men, 44.3% had NGT, 26.6% had prediabetes, and 29.1% had diabetes. In women, the distribution was 56.1%, 28.8% and 15.2%. The prevalence of sarcopenia was 12.7% in men and 11.9% in women. Logistic regression revealed that prediabetes and diabetes are independent risk factors for sarcopenia in men (prediabetes, odds ratio [OR] = 2.081 [95% confidence interval {CI}: 1.031–4.199]; diabetes, OR = 2.614 [95% CI: 1.362–5.018]) and diabetes, but not prediabetes, is an independent risk factor for sarcopenia in women (prediabetes, OR = 1.036 [95% CI: 0.611–1.757]; diabetes, OR = 2.099 [95% CI: 1.146–3.844]). In both sexes, higher age (men, OR = 1.086 [95% CI: 1.028–1.146]; women, OR = 1.195 [95% CI: 1.142–1.251]), higher body fat percentage (men, OR = 1.346 [95% CI: 1.240–1.461]; women, OR = 1.218 [95% CI: 1.138–1.303]) and lower body mass index (men, OR = 0.371 [95% CI: 0.299–0.461]; women, OR = 0.498 [95% CI: 0.419–0.593]) were independent risk factors for sarcopenia. Conclusions Although we confirmed that diabetes mellitus is associated with sarcopenia in both sexes, prediabetes is associated with sarcopenia in men, but not in women.

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“…12 Older individuals and patients with chronic diseases, such as hypertension, diabetes, coronary artery disease and COPD, suffer from skeletal muscle weakness and have a higher prevalence of developing sarcopenia. 5,13,14 Sarcopenia is characterized by the slow and progressive loss of muscle mass and strength, and is associated with ageing. Sarcopenia is an independent risk factor for frailty and mortality.…”

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confidence: 99%