Prevalence and Risk Factors of ACO (Asthma-COPD Overlap) in Aboriginal People

Abstract

Background and Objective Aboriginal peoples are at a higher risk of many chronic respiratory diseases compared to the general Canadian population. Patients with asthma-COPD overlap (ACO), a disease newly described in 2015, are associated with frequent exacerbations, rapid decline in lung function, poor quality of life, high mortality, and disproportionate utilization of health-care resources than patients with asthma and COPD alone. The objective was to investigate the prevalence and risk factors of ACO in Aboriginal peoples. Methods Data from the 2012 Aboriginal Peoples Survey (APS) were used for this study. The ACO definition was based on the respondent giving positive responses to both of the following questions “Do you/Does (name) have Asthma diagnosed by a health professional?” and “Do you/Does (name) have chronic bronchitis, emphysema or chronic pulmonary obstructive disease or COPD diagnosed by a health professional?” Results. Aboriginal peoples older than 45 years, women, widowed, separated, or divorced, having a total personal income below $20,000 were associated with a significant risk of ACO. Residing in Ontario, being a daily smoker, living in a rented dwelling, dwelling in need of major repairs, having diabetes, and working more than 40 hrs a week were also significantly associated with increased risk of ACO. Conclusion The results from this study will provide information to aid the development of prevention and intervention strategies for Aboriginal communities.

Global prevalence of asthma-COPD overlap (ACO) in the general population: a systematic review and meta-analysis

“…The study characteristics of the included studies are summarized in Table 2. In total, we included 27 studies published since 2011, except for one study that published in 1996: twelve from Europe [10, 12, 13, 16, 17, 20, 23, 25, 28–30, 35], nine from the North America (United States and Canada) [11, 15, 18, 21, 26, 27, 32–34], three East Asia (China and Korea) [19, 22, 36], three from the Latin America and 6 low- and middle-income countries and Australia [14, 24, 31]. The majority of the included studies were published after 2015.…”

The Prevalence of Bronchodilator Responsiveness “Asthma” Among Adult Indigenous Australians Referred for Lung Function Testing in the Top End Northern Territory of Australia

“…20,21 A previous self-reported survey among Canadian Indigenous people observed that prevalence of asthma/COPD overlap could be higher among Indigenous people. 48 The findings of our study indicate that among Indigenous Australians, conditions other than asthma or concurrent presence of asthma and COPD, 23,24 or bronchiectasis alongside asthma 25 could explain the apparently high rates of self-reported asthma in previous population surveys.…”

Statin use and Vital Organ Failure in Patients With Asthma–Chronic Obstructive Pulmonary Disease Overlap: A Time-Dependent Population-Based Study

“…This retrospective cohort study analyzed the effects of statins, ICS, and OS exposure on patients with ACO. The prevalence of ACO among young adults was found in many studies in the real world (de Marco et al, 2013; de Marco et al, 2015; Ekerljung et al, 2018), especially in the aboriginal population (Koleade et al, 2018). We identified patients aged 20 years and above with ACO and diagnosed with COPD ( ICD-9-CM codes 491, 492, and 496) from January 1, 2000, to December 31, 2010.…”