Prevalence and risk factors of microalbuminuria among type 2 diabetes mellitus: A hospital-based study from, Warri, Nigeria

Chukwuani, Ufuoma; Ngozi, J Chukwuebuni; Kester, A Digban; Godwin, Yovwin D

doi:10.4103/1118-8561.181889

Cited by 15 publications

(17 citation statements)

References 1 publication

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“… 13 The cause of this phenomenon should be investigated in further studies. Our study also fails to demonstrate any difference between these two groups based on their BMI and it is in accordance of previous study 14 and it is also due to the fact that majority of our study subjects in both groups were either overweight or obese.…”

Section: Discussionsupporting

confidence: 91%

Microalbuminuria in Type-2 Diabetes Mellitus; the tip of iceberg of diabetic complications

Ahmad¹,

Ulhaq²,

Mawani³

et al. 2017

Pak J Med Sci

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Objective:To determine the prevalence of microalbuminuria and its association with hypertension and other diabetic complications among Type-2 diabetic patients attending at Aga Khan University Hospital Karachi.Methods:1280 Type-2 diabetes patients who visited the outpatient department of Aga Khan University Hospital from September 2014 to August 2016 were included in the study. Microalbuminuria was diagnosed if spot urinary microalbumin excretion was confirmed to be more than 20mg/l. Hypertension was diagnosed if BP >140/90 or already on antihypertensive medications. Other demographic, clinical and laboratory data were also recorded.Results:Microalbuminuria was diagnosed in 404(31.56%) patients and among these albuminuric patients 335(82.9%) had hypertension. They were also dyslipidemic, having raised triglyceride levels, lower HDL levels, with more prevalence of background diabetic retinopathy and peripheral neuropathy. They also showed higher HbA1C levels and longer duration of diabetes.Conclusion:The prevalence of the microalbuminuria in our patients with Type-2 diabetes is 31.56% and is not only an early sign of diabetic nephropathy but also a host of other diabetic complications and should be dealt early with strict control of their hyperglycemia and hypertension to help prevent the future complications.

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Section: Discussionsupporting

confidence: 91%

Microalbuminuria in Type-2 Diabetes Mellitus; the tip of iceberg of diabetic complications

Ahmad¹,

Ulhaq²,

Mawani³

et al. 2017

Pak J Med Sci

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“…Thus, duration of DM in Type 2 diabetic patients should be interpreted with caution. It is interesting that in a study conducted by Alleyn et al [21] on the impact of duration of Type 1 DM on persistent microalbuminuria, there was no difference among duration groups in the young Journal of Diabetes Research children (8-12 years) while in older children and adolescent (13)(14)(15)(16)(17)(18) years, persistent microalbuminuria varied significantly by the duration group. This variation in findings in the above studies may be due to clinical differences [21], genetics, definition of diabetes exposure, control of glucose levels, or lifestyle.…”

Section: Discussionmentioning

confidence: 96%

“…The prevalence of microalbuminuria of 27.14% is comparable to what was observed in the current study. Variations in the prevalence of microalbuminuria has been attributed to several factors like difference in populations, the definition of microalbuminuria by different laboratories, and the method of urine collection and of measurement of microalbuminuria [16]. Nevertheless, microalbuminuria in adults who formed the majority of our study participants is believed to be an early risk marker for nephropathy [17].…”

Section: Discussionmentioning

confidence: 99%

Microalbuminuria and Traditional Serum Biomarkers of Nephropathy among Diabetic Patients at Mbarara Regional Referral Hospital in South Western Uganda

Kiconco

Rugera

Kiwanuka

2019

Journal of Diabetes Research

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Background. Diabetic nephropathy (DN) is a common finding in diabetic patients. Microalbuminuria is the earliest clinical evidence of DN. Early detection of microalbuminuria is very important; it allows timely interventions to prevent progression to macroalbuminuria and later end-stage renal disease (ESRD). Objectives. To determine the prevalence of microalbuminuria in diabetic patients and establish its association with traditional serum renal markers in assessment of incipient nephropathy. Methods. This cross-sectional study involved 140 participants with diabetes mellitus (DM) attending the diabetic clinic of Mbarara Regional Referral Hospital. Questionnaires were used to obtain participant data after obtaining written informed consent. Data collected included: age, sex, level of education, history of smoking and alcohol consumption, hypertension, body mass index, family history, and duration of DM. Morning spot urine samples were collected from each participant and blood drawn for analysis of other renal markers. Urine microalbumin was determined quantitatively using immunoturbidity assay (Microalbumin kit, Mindray). Serum creatinine and uric acid and glucose levels were determined by spectrophotometric methods. Results. The overall prevalence of microalbuminuria was 22.9%. Using a simple and multiple linear regression model, serum creatinine (β=0.010, 95% CI (0.005, 0.014), P=0.0001) and glucose (β=0.030, 95% CI (0.011, 0.048), P=0.0017) levels were significantly associated with microalbuminuria. After adjusting for linearity, family history of DM was the only predictor of microalbuminuria (β=0.275, 95% CI (0.043, 0.508), P=0.002). Although microalbuminuria was weakly associated with eGFR (OR=1.2, 95% CI (0.24, 5.96)), the relationship was not statistically significant (P=0.824). Conclusion. The prevalence of microalbuminuria in patients with diabetes in this study was high. The study suggests the need to screen for microalbuminuria early to reduce the possible burden of ESRD. When serum creatinine is used as a renal function marker among diabetic patients, it should be combined with microalbuminuria for better assessment of incipient nephropathy.

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“…The main stages of diabetic nephropathy are hyperfiltration, microalbuminuria, and frank proteinuria [10]. Microalbuminuria is not only an early marker of diabetic nephropathy but is also considered an indicator of morbidity and mortality in diabetic patients [11,12].…”

Section: Introductionmentioning

confidence: 99%

The findings of corneal specular microscopy in patients with type-2 diabetes mellitus

et al. 2020

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Background: We aimed to compare the morphological characteristics of corneal endothelial cells in type 2 diabetic patients and age-matched healthy subjects by specular microscopy. We also aimed to determine the association of corneal morphological features with the general characteristics and laboratory data of diabetic patients, including disease duration, haemoglobin A1c (HbA1c) levels and urine albumin creatinine ratio. Methods: A total of 195 diabetic patients and 100 healthy controls were enrolled in the study. All participants underwent a complete ophthalmological examination. Corneal endothelial measurements were performed using a noncontact specular microscopy. Laboratory data including serum fasting glucose, haemoglobin A1c levels, creatinine levels, and the urinary albumin-to-creatinine ratio were recorded. Diabetic patients were further subdivided into 3 groups according to the presence and stage of diabetic retinopathy. Specular microscopy findings and central corneal thickness of all patients were compared. Results: The ECD and hexagonal cell ratio were significantly lower, while the average cell size, CV%, and central corneal thickness were determined to be significantly higher in diabetic patients than in healthy controls (p = 0.001). With the presence and advancement of diabetic retinopathy, the ECD and hexagonal cell ratio decreased, while the average cell size, CV%, and central corneal thickness increased. When correlation analysis was performed between corneal morphological features and laboratory data of diabetic patients, ECD showed a significant negative correlation with diabetes duration (p = 0.028). HbA1c levels, urinary albumin-creatinine ratio (p = 0.041), average cell size and CV showed a positive correlation with these parameters. Conclusion: In conclusion, keratopathy is an important complication of type 2 diabetes. With an increase in the stage of diabetic retinopathy, alterations in corneal findings also increased. In that respect, we can suggest that keratopathy should be evaluated more cautiously in diabetic patients.

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Prevalence and risk factors of microalbuminuria among type 2 diabetes mellitus: A hospital-based study from, Warri, Nigeria

Cited by 15 publications

References 1 publication

Microalbuminuria in Type-2 Diabetes Mellitus; the tip of iceberg of diabetic complications

Microalbuminuria in Type-2 Diabetes Mellitus; the tip of iceberg of diabetic complications

Microalbuminuria and Traditional Serum Biomarkers of Nephropathy among Diabetic Patients at Mbarara Regional Referral Hospital in South Western Uganda

The findings of corneal specular microscopy in patients with type-2 diabetes mellitus

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