Prevalence and risk factors of Mycobacterium tuberculosis complex infection in slaughtered cattle at Jos South Abattoir, Plateau State, Nigeria

Okeke, Lilian; Cadmus, Simeon; Okeke, Ikenna Osemeka; Muhammad, Maryam; Awoloh, Oluchi; Dairo, Magbagbeola David; Waziri, Endie; Olayinka, Adebola; Nguku, Patrick; Fawole, Olufunmilayo I.

doi:10.11604/pamj.supp.2014.18.1.3841

Cited by 8 publications

(11 citation statements)

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“…However, the bivariate analysis indicated no signi cant association between zebu breeds and other breeds, most likely due to the fact that meat production in the state of Mato Grosso is mainly of zebu cattle, which is more representative in the sampling due to of the amount of cattle sent for slaughter during the study period. Similarly, studies carried out in Nigeria indicated no statistically signi cant differences concerning positive M. bovis diagnoses associated with breed, thus corroborating the results obtained herein (Akinseye et al 2018;Okeke et al 2014).…”

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confidence: 88%

Risk Factors Associated With the Presence of Mycobacterium Bovis in Macroscopic Lesions Suspected as Being Caused by Bovine Tuberculosis Detected in Slaughterhouses

Barcelos

Anjos

Alencar

et al. 2021

Preprint

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Mycobacterium bovis is a bacterium belonging to the Mycobacterium tuberculosis complex that causes tuberculosis in cattle and in other domestic and wild animals, as well as in humans. Disease control measures are carried out by slaughtering animals tested positive in the intradermal tuberculinization test and sanitation of their original living spaces, in addition to epidemiological surveillance carried out through the sanitary inspection of bovine carcasses in slaughterhouses. In the latter, official inspection services collect samples from macroscopic lesions suspected of bovine tuberculosis, which are then sent for laboratory analysis. Knowledge concerning the variables associated with the occurrence of M. bovis can aid in decision-making regarding control and disease eradication efforts. In this context, the aim of this study was to identify the risk factors for a positive M. bovis diagnosis in suspected bovine tuberculosis lesions obtained during epidemiological surveillance activities in the state of Mato Grosso, Brazil. A total of 105 suspicious lesions were analyzed using the Nested Polymerase Chain Reaction (nested q-PCR) method, of which 14 (13.33%) tested positive for M. bovis. Univariate and bivariate statistical analyses indicated that the variable “animal slaughter” was the only risk factor presenting statistical significance associated with the diagnosis of M. bovis (p < 0.05), demonstrating that macroscopic lesions suspected as being caused by bovine tuberculosis from animals with an in vivo diagnosis were 2.82 - fold more likely to result in a positive M. bovis diagnosis by molecular tests.

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Section: )supporting

confidence: 88%

Risk Factors Associated With the Presence of Mycobacterium Bovis in Macroscopic Lesions Suspected as Being Caused by Bovine Tuberculosis Detected in Slaughterhouses

Barcelos

Anjos

Alencar

et al. 2021

Preprint

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“…[20,21,22,31,32,33,34,35,36,37,38,39,40,41,42]; nine reporting on Leptospira spp. [22,26,27,28,43,44,45,46,47]; 13 reporting on Coxiella burnetii [23,24,25,39,40,41,48,49,50,51,52,53,54]; five on Mycobacterium bovis [42,55,56,57,58]; eight on Rickettsia spp. [25,53,54,59,60,61,62,63]; five reporting on Anaplasma spp.…”

Section: Resultsmentioning

confidence: 99%

“…Sa’idu et al (2014) conducted a study to establish the prevalence of bovine tuberculosis in slaughtered cattle using PCR and Ziehl-Neelsen (ZN) staining and found an overall prevalence rate of 8.3% [56]. In study of bovine tuberculosis in slaughtered cattle in Nigeria, the prevalence of mycobacterium TB was 21.4% (acid-fast bacilli test) and 16.7% (duplex PCR) [58]. The presence of lesions in lungs was highly associated (OR = 52.3; 95% CI: 16.4–191.8) with positive results for acid-fast bacilli (AFB) test compared to those without lesions.…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of Important Bacterial Zoonoses in Africa in the Last Decade in Light of the ‘One Health’ Concept

2019

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Zoonoses present a major public health threat and are estimated to account for a substantial part of the infectious disease burden in low-income countries. The severity of zoonotic diseases is compounded by factors such as poverty, living in close contact with livestock and wildlife, immunosuppression as well as coinfection with other diseases. The interconnections between humans, animals and the environment are essential to understand the spread and subsequent containment of zoonoses. We searched three scientific databases for articles relevant to the epidemiology of bacterial zoonoses/zoonotic bacterial pathogens, including disease prevalence and control measures in humans and multiple animal species, in various African countries within the period from 2008 to 2018. The review identified 1966 articles, of which 58 studies in 29 countries met the quality criteria for data extraction. The prevalence of brucellosis, leptospirosis, Q fever ranged from 0–40%, 1.1–24% and 0.9–28.2%, respectively, depending on geographical location and even higher in suspected outbreak cases. Risk factors for human zoonotic infection included exposure to livestock and animal slaughters. Dietary factors linked with seropositivity were found to include consumption of raw milk and locally fermented milk products. It was found that zoonoses such as leptospirosis, brucellosis, Q fever and rickettsiosis among others are frequently under/misdiagnosed in febrile patients seeking treatment at healthcare centres, leading to overdiagnoses of more familiar febrile conditions such as malaria and typhoid fever. The interactions at the human–animal interface contribute substantially to zoonotic infections. Seroprevalence of the various zoonoses varies by geographic location and species. There is a need to build laboratory capacity and effective surveillance processes for timely and effective detection and control of zoonoses in Africa. A multifaceted ‘One Health’ approach to tackle zoonoses is critical in the fight against zoonotic diseases. The impacts of zoonoses include: (1) Humans are always in contact with animals including livestock and zoonoses are causing serious life-threatening infections in humans. Almost 75% of the recent major global disease outbreaks have a zoonotic origin. (2) Zoonoses are a global health challenge represented either by well-known or newly emerging zoonotic diseases. (3) Zoonoses are caused by all-known cellular (bacteria, fungi and parasites) and noncellular (viruses or prions) pathogens. (4) There are limited data on zoonotic diseases from Africa. The fact that human health and animal health are inextricably linked, global coordinated and well-established interdisciplinary research efforts are essential to successfully fight and reduce the health burden due to zoonoses. This critically requires integrated data from both humans and animals on zoonotic diseases.

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“…Similar to our results, Grisi Filho et al (2011), when evaluating animals condemned for BTB according to the isolation of M. bovis in the state of São Paulo, reported greater positivity in females (58.89%). Other studies conducted with female bovines slaughtered at old age, which demonstrated a high occurrence of lesions suggestive of BTB followed by significant positivity rates in bacterial isolation, have also been found in the literature (Damina et al 2011, Okeke et al 2014. Those authors suggested that the findings may be related to the chronic character of the disease and the increased exposure of the animals to mycobacteria over time, considering that females have a longer productive life.…”

Section: Discussionmentioning

confidence: 77%

Isolation and genotyping of Mycobacterium bovis in suggestive lesions of tuberculosis in cattle slaughtered in the state of Ceará, Brazil

et al. 2020

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Bovine tuberculosis (BTB) is a zoonosis caused by the bacterium Mycobacterium bovis, which induces the development of nodular and granulomatous lesions in various animal tissues. The recognition of these suggestive gross lesions during postmortem sanitary inspection in slaughterhouses provides a presumptive diagnosis, which requires the use of complementary tests to confirm the disease. This study aimed to verify the occurrence of BTB in cattle slaughtered in slaughterhouses in the state of Ceará, Brazil, using bacteriological and molecular methods. To this end, suggestive lesions were analyzed on carcasses condemned by the “Serviço de Inspeção Estadual” (SIE). The samples were submitted to microbiological analysis using culture media and specific staining followed by spoligotyping molecular technique for identification and genotyping of the mycobacteria. Occurrence of lesions suggestive of BTB was verified in bovine carcasses (0.071%) from different municipalities of the state. These lesions were located mainly in the lung (95.12%), lymph nodes (58.53%), and liver (36.58%). Microbiological culture showed bacterial isolation (17.94%), with the growth of colonies showing morphological and tannic characteristics belonging to genus Mycobacterium spp. Genetic polymorphism analysis identified M. bovis in all isolates, which were discriminated into six spoligotypes (SB0121, SB0295, SB1064, SB0120, SB0870, and SB0852). These profiles have been described in Brazil and several areas of the world, except for profiles SB1064 and SB0852, which were described in the country for the first time. The results show that the association of the diagnostic methods used was the basis for the first study on identification of mycobacteria found in the state, which may provide a database for the epidemiological study of BTB in the state of Ceará.

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Prevalence and risk factors of Mycobacterium tuberculosis complex infection in slaughtered cattle at Jos South Abattoir, Plateau State, Nigeria

Cited by 8 publications

References 0 publications

Risk Factors Associated With the Presence of Mycobacterium Bovis in Macroscopic Lesions Suspected as Being Caused by Bovine Tuberculosis Detected in Slaughterhouses

Risk Factors Associated With the Presence of Mycobacterium Bovis in Macroscopic Lesions Suspected as Being Caused by Bovine Tuberculosis Detected in Slaughterhouses

Systematic Review of Important Bacterial Zoonoses in Africa in the Last Decade in Light of the ‘One Health’ Concept

Isolation and genotyping of Mycobacterium bovis in suggestive lesions of tuberculosis in cattle slaughtered in the state of Ceará, Brazil

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