Prevalence and Risk Factors of Diabetes Mellitus in β-thalassemia Major Patients in the North of Iran: Mazandaran β-thalassemia Registry - 2017 to 2019

Mortazavi, Parham; Darvish-Khezri, Mahdie; Hessami, Amirhossein; Abounoori, Mahdi; Kheirandish, Ali; Falegari, Farzane; Ghorbani, Mohammad; Ahmadi, Ali; Alikhani, Zahra; Karami, Hossein; Zahedi, Mohammad Javad; Darvishi‐Khezri, Hadi

doi:10.18502/tbsrj.v3i1.6171

Cited by 3 publications

(3 citation statements)

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“…The hematopoietically active spleen may influence pancreatic islet cell immune death, making splenomegaly a risk factor for diabetes. [13,22] In children with β-thalassemia major, clinical signs of blood glucose imbalance may appear. Hepatomegaly from iron overload or hepatitis C infection, failure to thrive, thalassemic cardiomyopathy heart abnormalities, and desferrioxamine toxicity bone alterations are examples.…”

Section: Symptoms and Signsmentioning

confidence: 99%

Indicators of Blood Glucose Imbalance in Children with Beta-thalassemia Major

Z Abdul Alamir Mezher,

Walaa Khalid Ali

2024

Aca. Intl. J. Med. Sci.

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Children diagnosed with beta-thalassemia major have a significantly increased likelihood of developing an imbalance in their blood glucose levels. It is essential to do screenings for diabetes and prediabetes in children, and to maintain a high degree of suspicion for abnormalities in blood glucose levels, since this is important for their management. Additionally, it is crucial to acknowledge other markers of blood glucose imbalance, including the glycated hemoglobin level, the fructosamine level, and the occurrence of hypoglycemic crises. Implementing preventive measures and closely monitoring one's health can effectively hinder the path towards diabetes. Thalassemia is a prevalent hereditary blood condition. The need for frequent blood transfusions in thalassemia leads to an excess of iron in the body, which has a role in the development of several disorders, including those affecting insulin production and function. This review examines the several markers of blood glucose dysregulation in children diagnosed with beta-thalassemia major. It also explores the impact of iron overload and other factors, such as the effects of desferioxamine and deferasirox. The review also discusses strategies for preventing diabetes and emphasizes the significance of a multidisciplinary team in caring for these youngsters

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Section: Symptoms and Signsmentioning

confidence: 99%

Indicators of Blood Glucose Imbalance in Children with Beta-thalassemia Major

Z Abdul Alamir Mezher,

Walaa Khalid Ali

2024

Aca. Intl. J. Med. Sci.

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“…Several studies have suggested that males with β-thalassemia are more prone to develop diabetes relative to female counterparts. Studies in Turkey and Iran demonstrated that the prevalence of diabetes in β-thalassemia is higher in male patients 18 19 . A similar pattern was observed in the UAE, where thalassemic males had significantly higher serum ferritin levels, higher incidence of diabetes, and higher rates of cardiomyopathy relative to their female counterparts 44 .…”

Section: Introductionmentioning

confidence: 98%

“…1). Therefore, long-term monitoring and management are essential to delay or mitigate anemia, skeletal deformities, heart failure, and diabetes among other complications [18][19][20]. This article aims to review the evidence linking diabetes with β-thalassemia major and explore the utility of early prediction biomarkers and the mechanism(s) underlying this association.…”

Section: Introductionmentioning

confidence: 99%

β-Thalassemia and Diabetes Mellitus: Current State and Future Directions

Taneera,

Mahgoub,

Qannita

et al. 2023

Horm Metab Res

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Abstractβ-Thalassemia major is a congenital hemoglobin disorder that requires regular blood transfusion. The disease is often associated with iron overload and diabetes mellitus, among other complications. Pancreatic iron overload in β-thalassemia patients disrupts β-cell function and insulin secretion and induces insulin resistance. Several risk factors, including family history of diabetes, sedentary lifestyle, obesity, gender, and advanced age increase the risk of diabetes in β-thalassemia patients. Precautionary measures such as blood glucose monitoring, anti-diabetic medications, and healthy living in β-thalassemia patients notwithstanding, the prevalence of diabetes in β-thalassemia patients continues to rise. This review aims to address the relationship between β-thalassemia and diabetes in an attempt to understand how the pathology and management of β-thalassemia precipitate diabetes mellitus. The possible employment of surrogate biomarkers for early prediction and intervention is discussed. More work is still needed to better understand the molecular mechanism(s) underlying the link between β-thalassemia and diabetes and to identify novel prognostic and therapeutic targets.

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