Prevalence and risk factors of potentially malignant disorders of the mucosa in the general population

Kindler, Stefan; Samietz, Stefanie; Dickel, Steffen; Mksoud, Maria; Kocher, Thomas; Lucas, Christian; Seebauer, Christian; Doberschütz, Philine H.; Holtfreter, Birte; Völzke, Henry; Metelmann, Hans‐Robert; Ittermann, Till

doi:10.1016/j.aanat.2021.151724

Cited by 9 publications

(5 citation statements)

References 43 publications

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“…In our study, when socioeconomic and environmental risks were analyzed, only smoking was statistically associated with OPMD/OSCC, showing a risk twice higher among the case group (adjusted OR = 2.22, p = 0.000, 95% CI = 1.535-3.217). This association was expected, since the contribution of smoking in increase the risk to develop precancerous oral lesions and oral cancer is frequent reported (Kindler et al, 2021;Wetzel & Wollenberg, 2020). Also, maternal smoking during pregnancy shows to be an important risk factor in the OC etiology of CL/P (Inchingolo et al, 2022;Little et al, 2004).…”

Section: Discussionmentioning

confidence: 90%

Polymorphisms associated with oral clefts as potential markers for oral pre and malignant disorders

da Silva,

Freitas,

Vieira

2023

Oral Diseases

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ObjectiveTo investigate whether genes in the Wnt pathway, which have been previously associated with both oral clefts and oral squamous cell carcinoma, are also associated with oral potentially malignant disorders (leukoplakia, erythroplakia and lichen planus).Materials and MethodsCase–control study: Dataset consisted of clinical information linked to DNA samples from affected subjects diagnosed with oral potential malignant disorders and oral cancer and their matched controls. Individual samples, clinical history, and potential risk factors were obtained through the Dental Registry and DNA Repository project of the School of Dental Medicine, University of Pittsburgh. The rs1533767 (WNT11), rs9879992 (GSK3B), and rs3923087 (AXIN2) were tested. After genomic DNA had been extracted, genotyping was performed blindly to clinical diagnosis status. Representation of genotypes and alleles in affected subjects in comparison to the unaffected individuals was determined using PLINK. Additional analysis was performed to investigate associations between environmental (socioeconomic/lifestyle) risk factors and the oral pathologies studied using STATA.ResultsTwo of the SNPs tested (rs9879992 in GSK3B and rs3923087 in AXIN2) were statistically, significantly associated with the pathologies studied (p = 0.039 and 0.038, respectively).ConclusionSingle‐nucleotide polymorphisms in genes in the Wnt pathway were associated with oral potentially malignant disorders.

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Section: Discussionmentioning

confidence: 90%

Polymorphisms associated with oral clefts as potential markers for oral pre and malignant disorders

da Silva,

Freitas,

Vieira

2023

Oral Diseases

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“…This was true for leukoplakia (0.8 to 1.9% difference depending on the age cohort), with a slight difference described for lichen ruber mucosa (0.3% DMS V vs 0.4% in our study) as well as for tumours (0.2% DMS V vs 0.1% in our study) (Hertrampf 2016a , 2016b , 2016c ). Another comprehensive longitudinal population-based study, the ‘Study of Health in Pomerania’ (SHIP), showed a slightly higher value of 0.9% for potentially malignant lesions (Kindler et al 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Early detection of oral cancer: a key role for dentists?

Hertrampf

Jürgensen

Wahl

et al. 2022

J Cancer Res Clin Oncol

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Purpose The majority of suspected malignant changes in the oral mucosa are detected by dentists in private practice. Statements regarding the effectiveness of visual examination of the oral cavity for early detection are not necessarily transferable between different health care systems. Our clinical-epidemiological and methodological aim was thus to conduct a prospective regional study in dental practices under everyday conditions, assess the frequency and type of oral mucosal changes, and evaluate the dental examination methodology. Methods A prospective observational study was conducted, combining a feasibility study of early detection of oral cancer and its documentation with phase I ‘modelling’ to conceptualize complex interventions in health services research. Dentists in private practice continuously recruited patients over 6 months and used two different sheets for the documentation of suspicious lesions. Statistical analysis involved descriptive statistics and tests for differences (Welch test) or association (Chi-squared test). Results Twenty-five dentists (mean age: 50 years, 24% females) participated in this study. Eleven dentists achieved the overall aim of recruiting 200 patients. Around 4200 patients (mean age: 52 years, 57.5% females) participated. The prevalence of suspicious lesions was 8.5%. Conclusion It became apparent that a study in cooperation with dentists in private practice to generate clinical-epidemiological data on the early detection of oral mucosal lesions under everyday conditions can be carried out successfully. Further studies with a corresponding level of evidence should be carried out to be able to draw conclusions about the effectiveness of the early detection measure under everyday practice conditions.

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“…Regular oral health screenings become increasingly important as individuals age to detect and manage lesions early. In terms of sex, studies suggest that males have a higher incidence of potentially malignant disorders, possibly due to higher rates of tobacco and alcohol consumption [19]. However, it is important to note that these lesions can affect individuals of any gender, emphasizing the need for preventive measures for everyone.…”

Section: Leukoplakiamentioning

confidence: 99%

Genetic Revelation of the Potentially Malignant Disorders in the Oral and Maxillofacial Region

Krishna Das,

Shafiul Kadir,

Ullah Shemanto

et al. 2024

Genetics

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The oral and maxillofacial region is the site of numerous cancer forms. The most frequent cancer, which accounts for more than 90% of these tumors, is squamous cell carcinoma. Genetic changes caused by malignant transformation later result in phenotypic changes in cells. Potentially malignant disorders and circumstances can lead to the development of some malignancies, such as oral squamous cell carcinomas (OSCCs). Because OSCC and precursor lesions cannot be detected early, the 5-year survival rate for OSCC is still only about 50%. Early detection of oral cancer, particularly in the premalignant stage, can greatly reduce death and morbidity. The clinical, histological revelations and etiopathogenesis of a few potentially malignant disorders of the oral and maxillofacial region are reviewed in this chapter.

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Prevalence and risk factors of potentially malignant disorders of the mucosa in the general population

Cited by 9 publications

References 43 publications

Polymorphisms associated with oral clefts as potential markers for oral pre and malignant disorders

Polymorphisms associated with oral clefts as potential markers for oral pre and malignant disorders

Early detection of oral cancer: a key role for dentists?

Genetic Revelation of the Potentially Malignant Disorders in the Oral and Maxillofacial Region

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