Prevalence and risk of bone fractures in patients with chronic pancreatitis: meta-analysis

Андреев, Д. Н.; Маев, И. В.; Кучерявый, Ю. А.

doi:10.47360/1995-4484-2021-56-61

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…(2021 г. ), обобщившем результаты 6 исследований, показано, что обобщенная частота переломов у пациентов с ХП составила 14,09% (95% ДИ 5,877-25,098) [38]. Помимо остеопороза прогрессирующая мальнутриция при ЭНПЖ повышает риск развития саркопении [39].…”

Section: осложненияunclassified

Exocrine pancreas insufficiency: clinical significance and approaches to correction from evidence medicine

Маев

Вениаминович²,

Kucheryavy³

et al. 2021

Terapevticheskii arkhiv

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Exocrine pancreatic insufficiency (EPI) is a common complication of both benign and malignant diseases of the pancreas, as well as a consequence of radical surgical operations on the pancreas and a whole range of other variable extra-pancreatic causes. In clinical practice in the adult population, most cases of EPI are associated with chronic pancreatitis, while in the pediatric population with cystic fibrosis. The regression of the production of digestive enzymes in EPI mediates the development of the syndrome of maldigestion and malabsorption, leading to the progressive development of malnutrition, the importance of which is often underestimated by practitioners. At the same time, the development of nutritional deficiency is not just a complication of EPI, but also has an important effect on the course of the underlying causative disease, worsening the prognosis and quality of life of the patient, and is also a proven risk factor for osteoporosis and sarcopenia. To date, compensation for the absolute deficiency of pancreatic enzymes using enzyme replacement therapy is the only possible way to correct the EPI and prevent nutritional deficiency.

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Section: осложненияunclassified

Exocrine pancreas insufficiency: clinical significance and approaches to correction from evidence medicine

Маев

Вениаминович²,

Kucheryavy³

et al. 2021

Terapevticheskii arkhiv

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Changes in the Intestinal Microbiota in Patients with Chronic Pancreatitis: Systematizing Literature Data

Маев

Levchenko

Andreev

2022

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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The purpose of the review. To systematize literature data on changes in the structure of the intestinal microbiota in patients with chronic pancreatitis (CP).Key findings. The human intestinal microbiota is a dynamically changing system that is constantly undergoing qualitative and quantitative changes, especially in several pathological conditions of the digestive system. At present, the differences in the intestinal microbiota in pancreatic diseases are poorly understood. The severe CP is associated with impaired synthesis of antimicrobial peptides, bicarbonates, and digestive enzymes by the pancreas, which is a risk factor for dysbiotic changes in the intestinal microbiota, consisting in the development of small intestinal bacterial overgrowth (SIBO) and gut dysbiosis. The results of two large meta-analyses show that about a third of CP patients have SIBO. The colonic microbiota in patients with CP is also characterized by dysbiotic disorders, primarily in the reduction of alpha-diversity. Some studies have shown that these patients have an increase in Firmicutes, while Bacteroides and Faecalibacterium are reduced. In addition, as a rule, in patients with CP, the growth of Escherichia, Shigella and Streptococcus is recorded.Conclusion. In general, scientific papers have revealed significant heterogeneity in the profiles of the intestinal microbiota in patients with CP. Thus, several questions remain open, prioritizing the further study of the intestinal microbiota in patients with CP for identifying the specifics of its structure that can personalize the selection of enzyme replacement therapy and restrict the unreasonable prescription of additional pharmacotherapy (the use of proton pump inhibitors and / or antibacterial drugs).

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Prevalence and risk of bone fractures in patients with chronic pancreatitis: meta-analysis

Abstract: О р и г и н а л ь н ы е и с с л е д о в а н и я

Cited by 2 publications

References 39 publications

Exocrine pancreas insufficiency: clinical significance and approaches to correction from evidence medicine

Exocrine pancreas insufficiency: clinical significance and approaches to correction from evidence medicine

Changes in the Intestinal Microbiota in Patients with Chronic Pancreatitis: Systematizing Literature Data

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