Prevalence and severity of asthma, rhinitis, and atopic eczema: the north east study

Shamssain, Mohammad; Shamsian, Negin

doi:10.1136/adc.81.4.313

Cited by 60 publications

(42 citation statements)

References 27 publications

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“…In older boys, aged 13-14, only asthma was more prevalent than in girls [9]. Similar findings were revealed in cross--sectional surveys in England, which found a higher prevalence of allergic rhinitis in prepubertal males [10,11]. One of the most seminal studies was performed in Scotland and involved a population sample of 266,733 [12].…”

Section: Discussionsupporting

confidence: 72%

The Prevalence of Allergic Diseases in Poland – the Results of the PMSEAD Study in Relation to Gender Differences

Liebhart¹,

Dobek²,

Małolepszy³

et al. 2014

Adv Clin Exp Med

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Background. Males and females exhibit different susceptibility to allergic diseases. Objectives. The aim of the study was to evaluate gender-related differences in the prevalence of allergic diseases in Poland. Material and Methods. To evaluate this problem, data from the Polish Multicenter Study of the Epidemiology of Allergic Diseases (PMSEAD) was analyzed. There were assessed 16,238 individuals, aged 3 to 80 years, among them 12,970 adults and 3,268 children. Results. In adults the prevalence of asthma was 5.4%, seasonal allergic rhinitis 8.5%, persistent allergic rhinitis 3.0%, atopic dermatitis 1.6%, contact dermatitis 2.0%, and drug allergy 8.6%. In children asthma was diagnosed in 8.6% of the individuals assessed, seasonal allergic rhinitis in 8.6%, persistent allergic rhinitis in 2.1%, atopic dermatitis in 4.7%, contact dermatitis in 1.1% and drug allergy in 8.9%. Among the children in the sample, significantly higher prevalence rates were found in boys than in girls for asthma (10.9% vs. 6.3%; OR = 1.81; p < 0.001), seasonal allergic rhinitis (9.8% vs 7.4%; OR = 1.37, p = 0.018) and persistent allergic rhinitis (2.6% vs. 1.5%; OR = 1.74, p = 0.029). When comparing the differences by gender among adults, there was a lower proportion of male than female subjects suffering from asthma (4.9% vs. 5.8%; OR = 0.83, p = 0.018), seasonal allergic rhinitis (7.6% vs. 9.3%; OR = 0.81, p = 0.001), atopic dermatitis (1.1% vs. 2.0%; OR = 0.53, p < 0.001), contact dermatitis (1.1% vs. 2.8%; OR = 0.39; p < 0.001) and drug allergy (5.1% vs. 11.6%; OR = 0.41, p < 0.001). Conclusions. The opposite susceptibility to allergic diseases among children and adults may indicate that sex hormones play an important role in this phenomenon (Adv Clin Exp Med 2014, 23, 5, 757-762).

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Section: Discussionsupporting

confidence: 72%

The Prevalence of Allergic Diseases in Poland – the Results of the PMSEAD Study in Relation to Gender Differences

Liebhart¹,

Dobek²,

Małolepszy³

et al. 2014

Adv Clin Exp Med

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“…Environmental factors have been thought to be important in determining the subsequent development of asthma [24]. One of the most important extrinsic factors that influence children's health is passive smoking [25][26][27]. The association between passive smoking and asthma in childhood is well known.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the prevalence of atopic diseases by ISAAC surveys in the primary school children of Sivas

Çelik¹

2012

CMJ

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Aim. During the past few decades, The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires have shown that the prevalence of childhood asthma and allergy is increasing worldwide. The aim of this cross-sectional study was to determine the change in prevalence and risk factors of asthma, allergic rhinitis, and eczema from two ISAAC questionnaire based surveys conducted on two groups of schoolchildren in Sivas, a central Anatolian city, during the years 1997 and 2005. Methods. The study populations of the two comparable cross-sectional surveys were comprised of schoolchildren aged 6-14. The sample size in 1997 and 2005 were 569 and 2978 children, respectively. Results. This study showed that the prevalence of asthma, allergic rhinitis and atopic eczema increased significantly from 9.7 % to 11.8%, 5.4% to 10.2%, and 3% to 10.1%, respectively. Risk factor analysis revealed that living with a dog or cat, body mass index (BMI), and family history of atopy were associated with higher risk of asthma (p<0.05). Conclusion. In the 8-year period from 1997 to 2005, the prevalence of asthma, allergic rhinitis, and eczema has increased significantly in our region. Further studies with larger number of patients are required to investigate the factors causing this increased local rate.

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“…A recent cross-sectional study of the UK general population reported a prevalence of asthma of 12% [1]. The prevalence of asthma is even higher in children; the prevalence rate of reported asthma was 23% in British children aged 6–7 years [2], and 21% in those aged 12–14 years [3]. …”

Section: Introductionmentioning

confidence: 99%

Anti-IgE Therapy in Asthma: Rationale and Therapeutic Potential

Barnes¹

2000

Int Arch Allergy Immunol

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Airway inflammation is found in virtually all individuals with asthma symptoms. The factors contributing to asthma-related airway inflammation are multiple and involve a number of different inflammatory cells and mediators. Allergic responses at the level of the respiratory system are mostly mediated by IgE-dependent mechanisms. After sensitization of a susceptible individual and the synthesis and binding of allergen-specific IgE to target cells, atopic individuals respond immunologically to common, naturally occurring allergens by releasing mast cell-derived mediators. Subsequent allergen exposure in susceptible individuals produces a characteristic cascade of events orchestrated by immune effector cells, most prominently, mast cells, T lymphocytes and eosinophils. A new strategy, neutralizing IgE antibodies, inhibits expression of allergic symptoms by preventing the initial trigger of the allergic reaction, IgE binding to IgE-receptor bearing cells. rhuMAb-E25 is a recombinant humanized monoclonal anti-IgE antibody currently under investigation that has been shown to reduce allergic responses in atopic individuals and to improve symptoms and reduce rescue medication and corticosteroid use in patients with allergic asthma. Thus, the clinical effectiveness of rhuMAb-E25 supports the central role of IgE in allergic reactions and the viability of anti-IgE therapy as a potentially effective treatment option for asthma.

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Prevalence and severity of asthma, rhinitis, and atopic eczema: the north east study

Cited by 60 publications

References 27 publications

The Prevalence of Allergic Diseases in Poland – the Results of the PMSEAD Study in Relation to Gender Differences

The Prevalence of Allergic Diseases in Poland – the Results of the PMSEAD Study in Relation to Gender Differences

Evaluation of the prevalence of atopic diseases by ISAAC surveys in the primary school children of Sivas

Anti-IgE Therapy in Asthma: Rationale and Therapeutic Potential

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