Prevalence and some risk factors with therapeutic trial of sheep dermatophytosis in Egypt

Fawzi, Elshaima M.; Abd-Elmegeed, Mohammed M.; El-Mekkawi, Mamdouh F.; El-Diasty, Eman M.; Morsi, Abdelkarem M.; Abd-Elfatah, Eman B.

doi:10.33899/ijvs.2022.133376.2214

Cited by 7 publications

(9 citation statements)

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“…Serological studies also confirm that several livestock animals are infected with T. gondii and they transmit this infection when their meat is consumed. Outbreaks of toxoplasmosis associated with raw meat consumption have been reported [27,28].…”

Section: Introductionmentioning

confidence: 99%

Public Health Significance of Human Toxoplasmosis

Alewy Almashhadany,

Aziz Jamil Alani,

Ahmed Dhiab

et al. 2024

Infectious Diseases

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Toxoplasmosis is a significant food-borne zoonotic disease that causes a wide range of clinical syndromes in humans, including pregnant women, immunosuppressed individuals, land and sea mammals, and various bird species. Felidae is the only definitive host that excretes a million oocysts of T. gondii in their feces, polluting the environment. T. gondii has a complex life cycle, with sexual reproduction occurring in cats, where oocysts are formed and excreted with feces. The meiosis of oocysts in the environment leads to the formation of sporozoites that are infectious to intermediate hosts, such as rodents and livestock animals. In these intermediate hosts, rapidly replicating tachyzoites are disseminated throughout the body, forming tissue cysts containing bradyzoites. Infected individuals become infected by ingesting oocysts from contaminated soil, water, or food. The transmission of toxoplasmosis is recognized as zoonotic transmission, with the primary route being through the ingestion of contaminated food or water, particularly undercooked or raw meat, and unwashed fruits and vegetables that have come into contact with the parasite’s oocysts. The signs and symptoms of toxoplasmosis can vary widely, with most healthy individuals having a normal immune system and mild symptoms resolving on their own.

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Section: Introductionmentioning

confidence: 99%

Public Health Significance of Human Toxoplasmosis

Alewy Almashhadany,

Aziz Jamil Alani,

Ahmed Dhiab

et al. 2024

Infectious Diseases

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“…cause skin diseases in animals, such as T. mentagrophytes, T. verrucosum, and M. canis, which are known as zoophilic dermatophytes [1][2][3][4] The geographical location, exposure to stress factors, environmental conditions, and age play an essential role in the spread of dermatophytes. Economically, the increasing concern of dermatophytosis is not triggered by its worldwide public health problems in terms of affecting millions of individuals annually, but also by its being one of the dermatologic problems in the veterinary field involving domestic and wild animals [5]. Dermatophytosis is a disease caused by dermatophytes, a group of fungi that can cause disease in humans and animals [6,7,4,8,9].…”

Section: Introductionmentioning

confidence: 99%

“…The clinical signs of ringworm appear 1-4 weeks after contact with fungal spores [5]. Infection with Microsporum canis is usually associated with alopecia, and infection has been diagnosed by isolation of fungus, which has characteristic hyphae or arthroconidia, from the patients' hair lesions [10].…”

Section: Introductionmentioning

confidence: 99%

Studying the Blood Virtues of Animals Spontaneously Infected with Microsporum spp. and the Scheme in the Treatment of the Fungal Disease Microsporum spp.

Alasgarova,

Omarov,

Naghiyeva

2024

ARRB

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This article focuses on performing clinical, laboratory examination, isolation, and identification of Microsporum spp., general and biochemical analyzes of the blood of spontaneously infected animals and the successful treatment of Microsporum spp. infection in cats and dogs using miconazole/chlorhexidine combination and itraconazole. Skin scraping, hair samples and blood samples were collected from a total of 132 animals. Out of 132 examined dogs and cats, 43 animals were diagnosed with the disease, 28 of the sick animals were cats and 15 were dogs. Based on the results of RBCs (Red Blood Cell) Count, HGB (Hemoglobin), HCT (Hematocrit), MCH (Mean Corpuscular Hemoglobin) blood tests and MCHC (Mean Corpuscular Hemoglobin Concentration), low levels of healthy red blood cells, hemoglobin, and low results in MCHC blood tests were observed in the blood of all of infected dogs and cats, a high level of AST (Aspartate Aminotransferase) is also observed in some infected animals. Among the sick animals, there were also animals with normal AST (Aspartate Aminotransferase) levels. In our study, 29 infected cats and dogs were treated with itraconazole and one of two topical therapies including 2% chlorhexidine and 2% miconazole shampoo (VetWELL Micoseb Medicated Shampoo for Dogs & Cats - Medicated Dog Shampoo with Miconazole, Chlorhexidine & Aloe for Skin Infection Treatment of Skin Conditions 12oz). This study aimed to perform clinical characteristics, laboratory examination, isolation and identification of zoophilic dermatophytes due to Microsporum spp. In addition, to evaluate general and biochemical analyses of the blood of spontaneously infected pets and stray and shelter animals with Microsporum spp. in Baku and Ganja cities in Azerbaijan, and to focus the treatment includes systemic and topical therapy.

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“…Dermatophytosis resulting from zoonotic transmission has been common in agricultural workers and is re-emerging as a significant public health problem worldwide (Seyedmousavi et al 2015) through contacts with pet. Classically, zoophilic dermatophytes have been common on livestock (El Jaouhai et al 2004;Dalis et al 2019;Fawzi et al 2023) leading to frequent human transmission (Deng et al 2008;Maslen 2000). Microsporum canis, T. mentagrophytes and T. verrucosum were among the most commonly isolated dermatophytes on large domesticated animals (Seebacher et al 2008); cattle dermatophytosis by Trichophyton verrucosum is still a primary veterinary health concern (Aghamirian et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Dermatophytes and hair: aspects of evolution of Arthrodermataceae

Tang

Zhou

Guillot

et al. 2023

Preprint

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Dermatophytes and other members of Onygenales are unique in their ability to degrade keratin, affecting hair and nails, and in case of human hosts cause infection of the skin. Subtillisins are essential proteases in keratin assimilation, and subtilisin-like protease 1 (SUB1) and SUB3–7 are specific for dermatophytes. eIF2α kinases are serine-threonine kinases that perform essential functions in response to infection, proteotoxicity, and nutrient scavenging. The relatively conserved nature of EIF2AK4 among fungi makes them potential evolutionary markers, which may contribute to a deeper understanding of dermatophyte taxonomy and evolution. The aim of the present study was to evaluate the phylogeny of dermatophytes using EIF2AK4 and SUB1 genes, compared to ITS evolution. The EIF2AK4 tree had a similar topology to the SUB1 tree, and both deviated from the ITS gold standard by evolution. Our preliminary findings with a limited dataset suggest that the EIF2AK4 and SUB1 genes provide a reasonably correct reflection of the evolution of Arthrodermataceae. In addition, the study analyzed in vitro keratinolytic responses of 19 dermatophyte species using hairs of a broad selection of mammals as substrates. Trichophyton mentagrophytes and Nannizzia gypsea were the most active in degrading hair, while Trichophyton verrucosum, Trichophyton tonsurans and Epidermophyton floccosum showed low response. Hairs of Hyracoidea and Rodentia were most affected of all mammal hairs, while in contrast, bat hairs were difficult to degrade by nearly all tested dermatophyte species. Zoophilic species showed more activity than anthropophilic dermatophytes, but hair degradation profiles were not diagnostic for particular dermatophyte species.

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Prevalence and some risk factors with therapeutic trial of sheep dermatophytosis in Egypt

Cited by 7 publications

References 0 publications

Public Health Significance of Human Toxoplasmosis

Public Health Significance of Human Toxoplasmosis

Studying the Blood Virtues of Animals Spontaneously Infected with Microsporum spp. and the Scheme in the Treatment of the Fungal Disease Microsporum spp.

Dermatophytes and hair: aspects of evolution of Arthrodermataceae

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