Prevalence and transmission of antibiotic resistance and microbiota between humans and water environments

Zhou, Zhen-Chao; Feng, Wanqiu; Han, Ying‐Hao; Zheng, Jing; Chen, Tao; Wei, Yuanyuan; Gillings, Michael R.; Zhu, Yong‐Guan; Chen, Hong

doi:10.1016/j.envint.2018.10.032

Cited by 105 publications

(31 citation statements)

References 47 publications

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“…Box and bar charts were generated by OriginPro 9.0 (OriginLab Corp., Northampton, MA). Network analysis was conducted in the Gephi platform and only statistically robust correlations of Spearman's correlation coefficient (ρ) > 0.9 and significance level P < 0.01 were used to form the final networks by Frucherman Reingold algorithms [26,31,32]. Phylogenetic tree was extracted from the taxa in MEGA7 program, using the maximum-likelihood tree with 500 bootstraps.…”

Section: Discussionmentioning

confidence: 99%

“…ARGs and MGEs were analyzed by high-throughput qPCR (HT-qPCR) using the Takara SmartChip™. For this, 285 antibiotic resistance gene primer sets for all major classes of antibiotics, 9 transposase gene primer sets, one clinical class 1 integron-integrase gene primer set, and one 16S rRNA gene primer set were evaluated (Table S1) [6,26]. The antibiotics resistance genes to aminoglycoside, betalactams, fluoroquinolone/quinolone/florfenicol/chloramphenicol/amphenicol (FCA), macrolide/lincosamide/streptogramin B (MLSB), sulfonamide, and tetracycline, vancomycin, and genes coding multidrug efflux pumps or antibiotic deactivation protein resistance to other antibiotic 6 and bactericide (multidrug) resistance genes were targeted by the 285 ARGs primer sets [5,27] (detailed HT-qPCR procedures are described in Supplementary Information Text S2).…”

Section: Introductionmentioning

confidence: 99%

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Antibiotic resistance associated with air quality and transferred by airborne particulate matter

Zhou

Liu

Lin

et al. 2020

Preprint

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Background: Environmental spread of antibiotic resistance has become a public health problem, but the relationship between air quality and antibiotic resistance has not been fully investigated, the effect and mechanism of air pollutants on horizontal genes transfer of antibiotic resistance are rarely mentioned. Results: In the present study, significant correlation ( P < 0.05) between resistance rates of 10 clinical antibiotic-resistant pathogens and number of days when air quality index was below 100 were observed in an extensive survey from 2014 to 2017 in China. In addition, characterization of antibiotic resistance genes (ARGs), mobile genetic elements (MGEs), and bacterial communities in airborne particulate matter (PM), dust, and human airway sputum samples were profiled in a hospital. PM 2.5 and PM 10 were shown to contain ARGs and MGEs high relative abundance and diversity index. Importantly, transferable multi-resistant plasmids were identified from air, e.g., pTAir-3 with 26 MGEs and 10 ARGs, using conjugative mating assays and nanopore sequencing . Furthermore, PM 2.5 and PM 10 significantly enhanced the conjugative transfer frequencies between bacteria, via inducing increased levels of reactive oxygen species and cell membrane permeability; upregulated gene expression levels were confirmed by genome-wide RNA sequencing. Conclusions: These findings provide a new perspective on antibiotic resistance research and have profound implications for antibiotic resistance control in clinics and environments.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibiotic resistance associated with air quality and transferred by airborne particulate matter

Zhou

Liu

Lin

et al. 2020

Preprint

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“…UWTP is one of the ecosystems that are believed to be probable hotspots for ARGs transfer since they combine several favourable factors such as high cell density sustained by a nutrient rich environment and a recurrent contamination with both antibiotics and resistant bacteria (Schluter et al 2008;Davies and Davies 2010). Analysis of ARGs and micro-biota in humans and in water environments (like UWTP and Slaughterhouse related treatment plants) helps to define the transmission routes and dynamics of antibiotic resistance within these environments to finally reach consumed food (Zhou et al 2018).…”

Section: Environmental Hotspots Of Args Transmission To Food-systemmentioning

confidence: 99%

“…Analysis of ARGs and micro‐biota in humans and in water environments (like UWTP and Slaughterhouse related treatment plants) helps to define the transmission routes and dynamics of antibiotic resistance within these environments to finally reach consumed food (Zhou et al . 2018).…”

Section: Environmental Hotspots Of Args Transmission To Food‐systemmentioning

confidence: 99%

Bacteriophages as antibiotic resistance genes carriers in agro‐food systems

Jebri

Rahmani

Hmaïed

2020

J. Appl. Microbiol.

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Antibiotic resistance genes (ARGs) are a global health concern. Antibiotic resistance occurs naturally, but misuse of antibiotics in humans and animals is accelerating the process of antibiotic resistance emergency, which has been aggravated by exposure to molecules of antibiotics present in clinical and agricultural settings and the engagement of many countries in water reuse especially in Middle East and North Africa region. Bacteriophages have the potential to be significant actors in ARGs transmission through the transduction process. These viruses have been detected along with ARGs in non impacted habitats and in anthropogenic impacted environments like wastewater, reclaimed water and manure amended soil as well as minimally processed food and ready to eat vegetables. The ubiquity of bacteriophages and their persistence in the environment raises concern about their involvement in ARGs transmission among different biomes and the generation of pathogenicresistant bacteria that pose a great threat to human health. The aim of this review is to give an overview of the potential role of bacteriophages in the dissemination and the transfer of ARGs to pathogens in food production and processing and the consequent contribution to antibiotic resistance transmission through faecal oral route carrying ARGs to our dishes.

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“…Rivers appear to be a reservoir of antibiotic resistance and play an important role in transportation of antibiotic resistance between various environmental compartments [ 15 , 16 ]. River water might create possible pathways for antibiotic resistance transmission between the environment, humans, and animals [ 17 ]. In this regard, similar patterns in antibiotic resistance of Escherichia coli ( E. coli ) isolates from humans, animals, and their water environment have been reported [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Monitoring of Water Quality, Antibiotic Residues, and Antibiotic-Resistant Escherichia coli in the Kshipra River in India over a 3-Year Period

Hanna

Purohit

Diwan

et al. 2020

IJERPH

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The emergence of antibiotic resistance is a major global and environmental health issue, yet the presence of antibiotic residues and resistance in the water and sediment of a river subjected to excessive anthropogenic activities and their relationship with water quality of the river are not well studied. The objectives of the present study were a) to investigate the occurrence of antibiotic residues and antibiotic-resistant Escherichia coli (E. coli) in the water and sediment of the Kshipra river in India at seven selected sites during different seasons of the years 2014, 2015, and 2016 and b) to investigate the association between antibiotic residues and antibiotic-resistant E. coli in water and sediment and measured water quality parameters of the river. Antibiotic residues and resistant E. coli were present in the water and sediment and were associated with the measured water quality parameters. Sulfamethoxazole was the most frequently detected antibiotic in water at the highest concentration of 4.66 µg/L and was positively correlated with the water quality parameters. Significant (p < 0.05) seasonal and spatial variations of antibiotic-resistant E. coli in water and sediment were found. The resistance of E. coli to antibiotics (e.g., sulfamethiazole, norfloxacin, ciprofloxacine, cefotaxime, co-trimoxazole, ceftazidime, meropenem, ampicillin, amikacin, metronidazole, tetracycline, and tigecycline) had varying associations with the measured water and sediment quality parameters. Based on the results of this study, it is suggested that regular monitoring and surveillance of water quality, including antibiotic residues and antibiotic resistance, of all rivers should be taken up as a key priority, in national and Global Action Plans as these can have implications for the buildup of antibiotic resistance.

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Prevalence and transmission of antibiotic resistance and microbiota between humans and water environments

Cited by 105 publications

References 47 publications

Antibiotic resistance associated with air quality and transferred by airborne particulate matter

Antibiotic resistance associated with air quality and transferred by airborne particulate matter

Bacteriophages as antibiotic resistance genes carriers in agro‐food systems

Monitoring of Water Quality, Antibiotic Residues, and Antibiotic-Resistant Escherichia coli in the Kshipra River in India over a 3-Year Period

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