Prevalence and treatment follow-up of drug-resistant extra-pulmonary tuberculosis in rural communities in Narshingdi, Bangladesh

Afroz, Hafsa; Ali, Md. Azhar; Fakruddin, Md.; Kamrunnahar,; Datta, Suvamoy

doi:10.5455/2349-3933.ijam20140801

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…A study from Bangladesh reported lymph nodes followed by the pleura as the two most common site of DR-TB. [17] Data on the distribution of DR-TB as per specimen/samples are available from Indian supranational laboratory, NIRT and Delhi. NIRT detected DR-TB in 19% of EP TB specimens.…”

Section: Discussionmentioning

confidence: 99%

Extrapulmonary drug-resistant tuberculosis at a drug-resistant tuberculosis center, Mumbai: Our experience – Hope in the midst of despair!

Desai

Joshi

2019

Lung India

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Background: Drug-resistant tuberculosis (DR-TB) is a global problem with only 52% reported cure rate. Extrapulmonary (EP) DR-TB poses a formidable diagnostic, therapeutic challenge. We aimed to study their clinical profile and treatment outcomes under the programmatic setting. Materials and Methods: This retrospective observational study included the database of consecutive EPDR-TB cases enrolled at the DR-TB center from 2012 to 2014. The demographic, clinical details, drug susceptibility tests (DSTs), follow-up, therapy, adverse events (AEs), and outcome were reviewed. Statistical analysis was done using percentages and mean. Results: Of total 1743 DR-TB patients, 76 (4.4%) EPDR-TB cases were included. These consisted of 53 (69.7%) adults and 23 (30.3%) children, with female preponderance. The mean age in adults and children was 27.96 (9.63) and 12.56 (3.83), respectively. EP sites involved were lymph nodes in 39 (51.3%), spine in 15 (19.7%), other bones in 6 (7.9%), pleural effusion in 9 (11.9%), central nervous system in 2 (2.6%), and disseminated EP disease in 5 (6.6%). Forty-one (53.9%) had multi-DR-TB (MDR-TB), 29 (38.2%) MDR-TB with fluoroquinolone resistance {preextensively DR-TB (Pre-XDR-TB (FQ)), 1 (1.3%) MDR-TB with aminoglycoside resistance (Pre-XDR-TB (AM)), and 5 (6.6%) extensively DR-TB (XDR-TB) on DST. Thirteen (17.11%) had comorbidities. None had HIV. Two (2.63%) had DM. Patients were treated as per the revised TB control program – programmatic management of DR-TB guidelines. Duration of intensive (IP) was 6.55 (1.22) months. Ten (13.2%) received shorter regimens, wherein therapy was stopped at 12–18 months due to severe adverse drug reactions and treatment response. Sixty-two (81.6%) completed treatment, 8 (10.5%) defaulted, 3 (4%) died, 2 (2.6%) failed, and 1 (1.3%) was transferred out. Two-third of patients reported AE. Conclusion: The prevalence of EP cases in DR-TB was 4.4%. Treatment completion rate was very high (81.6%). Shorter regimens were efficacious.

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Section: Discussionmentioning

confidence: 99%

Extrapulmonary drug-resistant tuberculosis at a drug-resistant tuberculosis center, Mumbai: Our experience – Hope in the midst of despair!

Desai

Joshi

2019

Lung India

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“…While, gastrointestinal, joints, skin, and other organs constitute remainder 29,30 . Among EPTB, TB involving the lymph nodes, pleura, and abdomen is the most common in Bangladesh 31–34 . In contrast, forms of EPTB that is, LNTB and TBM dominates in Afghanistan 35–37 …”

Section: Discussionmentioning

confidence: 99%

“…A cross‐sectional study conducted in rural Bangladesh that included 152 EPTB patients found that the disease was more common in females in the age group between 25 and 34 years. They also reported the distribution of sites of EPTB infection, which includes pleural (29.6%), glands (24.3%), abdominal (21%), spinal (19.7%), brain (4.6%), and cardiac (0.7%) 33 . A similar retrospective study of 200 EPTB cases discovered that EPTB was more common between the ages of 16 and 45 and among females (60%).…”

Section: Susceptibility Of Extrapulmonary Tb In South Asiansmentioning

confidence: 93%

“…They also reported the distribution of sites of EPTB infection, which includes pleural (29.6%), glands (24.3%), abdominal (21%), spinal (19.7%), brain (4.6%), and cardiac (0.7%). 33 A similar retrospective study of 200 EPTB cases discovered that EPTB was more common between the ages of 16 and 45 and among females (60%). While lymph nodes were the most common site involved (50%), the second most common involvement was tubercular pleural effusion (15%).…”

Section: Bangladeshmentioning

confidence: 94%

“…29,30 Among EPTB, TB involving the lymph nodes, pleura, and abdomen is the most common in Bangladesh. [31][32][33][34] In contrast, forms of EPTB that is, LNTB and TBM dominates in Afghanistan. [35][36][37]…”

Section: Indiamentioning

confidence: 99%

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Better understanding extrapulmonary tuberculosis: A scoping review of public health impact in Pakistan, Afghanistan, India, and Bangladesh

Jawed

Tharwani

Siddiqui

et al. 2023

Health Science Reports

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Background and Aims: South Asian countries, including Pakistan, Afghanistan, India, and Bangladesh, have a high prevalence of pulmonary and extra-pulmonary tuberculosis (EPTB). This prevalence is influenced by various risk factors such as ethnicity, nutrition, socioeconomic disparities, high out-of-pocket healthcare expenses, and specific Mycobacterium Tuberculosis (TB) lineages. The COVID-19 pandemic has likely hindered access to healthcare and led to under-reporting of EPTB cases nationally and internationally. This rapid review aimed to summarize the literature on the prevalence and disease outcomes of EPTB in the mentioned countries, compare the situations across countries, and provide recommendations for future action. Methods: The review utilized PubMed and Google Scholar databases to search for literature on EPTB in South Asian countries. The search string included keywords related to different forms of EPTB and the countries of interest while excluding pulmonary tuberculosis. Results:The results showed that both TB, including drug-resistant TB, and EPTB are prevalent and burdensome in South Asia. In Pakistan, pleural TB was the most commonly reported form of EPTB, followed by lymph node TB, abdominal TB, osteoarticular TB, Central Nervous System TB, and miliary TB. In India, lymph node TB(LNTB) was more common among EPTB cases. Bangladesh reported a high prevalence of EPTB involving lymph node, pleura, and abdomen, while Afghanistan had a higher prevalence of forms such as LNTB and tuberculous meningitis. Conclusion:In conclusion, the prevalence of EPTB in Pakistan, Afghanistan, India, and Bangladesh is alarmingly high and negatively impacts population health.Effective measures are needed for treatment and management of this condition,

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Genetic diversity and characterization of M. tuberculosis isolates causing extrapulmonary tuberculosis in Bangladesh

Uddin

Ather

Rahman

et al. 2021

Infection, Genetics and Evolution

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Prevalence and treatment follow-up of drug-resistant extra-pulmonary tuberculosis in rural communities in Narshingdi, Bangladesh

Cited by 7 publications

References 21 publications

Extrapulmonary drug-resistant tuberculosis at a drug-resistant tuberculosis center, Mumbai: Our experience – Hope in the midst of despair!

Extrapulmonary drug-resistant tuberculosis at a drug-resistant tuberculosis center, Mumbai: Our experience – Hope in the midst of despair!

Better understanding extrapulmonary tuberculosis: A scoping review of public health impact in Pakistan, Afghanistan, India, and Bangladesh

Genetic diversity and characterization of M. tuberculosis isolates causing extrapulmonary tuberculosis in Bangladesh

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