Prevalence and Treatment of Depression in Parkinson's Disease

Veazey, Connie

doi:10.1176/appi.neuropsych.17.3.310

Cited by 71 publications

(71 citation statements)

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“…Depression is one of the most common non-motor symptoms in patients with PD [34]. Depression was previously reported to be associated with falling in persons with PD [13,35,36].…”

Section: Discussionmentioning

confidence: 99%

The Relation of Falls to Fatigue, Depression and Daytime Sleepiness in Parkinson’s Disease

Bryant

Rintala²,

Hou

et al. 2012

Eur Neurol

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Objective: To characterize non-motor symptoms in individuals with Parkinson’s disease (PD) who experience falls compared to those who do not fall. Methods: Fifty-four individuals with PD were studied. Thirty-six were fallers and 18 were non-fallers. Fatigue was assessed by the Iowa Fatigue Scale. Excessive daytime sleepiness was assessed by the Epworth Sleepiness Scale, and depressive symptomatology was assessed by the short-form Center for Epidemiologic Studies Depression Scale. Results: Compared to non-fallers, fallers had more severe disability, greater general physical fatigue (p = 0.024), lower energy levels (p = 0.042) and less productivity (p = 0.007). Fallers had more depressive symptomatology than the non-fallers (p = 0.01). Excessive daytime sleepiness was not different between the two groups (p = 0.695). Conclusions: Individuals with PD who fell had more severe motor and non-motor symptoms than those who did not fall. These non-motor symptoms included physical fatigue, energy, productivity and depressive symptomatology.

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“…Depression is one of the most common non-motor symptoms in patients with PD [34]. Depression was previously reported to be associated with falling in persons with PD [13,35,36].…”

Section: Discussionmentioning

confidence: 99%

The Relation of Falls to Fatigue, Depression and Daytime Sleepiness in Parkinson’s Disease

Bryant

Rintala²,

Hou

et al. 2012

Eur Neurol

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“…Indeed, depression symptomatology can arise secondarily to for instance diverse neurological (e.g. Alzheimer's [14], Parkinson's [15] and Creutzfeldt-Jakob's disease [16]), immunological (e.g. interferon treatment [17]) and endocrine (e.g.…”

Section: Depression: a Heterogeneous Disease With Diverse Pathogenesis?mentioning

confidence: 99%

The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2^Arg439^Hisknockin mouse

Jacobsen

Medvedev

Caron

2012

Phil. Trans. R. Soc. B

165

105

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A decreased level of brain 5-hydroxytryptamine (5-HT) has been theorized to be a core pathogenic factor in depression for half a century. The theory arose from clinical observations that drugs enhancing extracellular levels of 5-HT (5-HT Ext ) have antidepressant effects in many patients. However, whether such drugs indeed correct a primary deficit remains unresolved. Still, a number of anomalies in putative biomarkers of central 5-HT function have been repeatedly reported in depression patients over the past 40 years, collectively indicating that 5-HT deficiency could be present in depression, particularly in severely ill and/or suicidal patients. This body of literature on putative 5-HT biomarker anomalies and depression has recently been corroborated by data demonstrating that such anomalies indeed occur consequent to severely reduced 5-HT Ext levels in a mouse model of naturalistic 5-HT deficiency, the tryptophan hydroxylase 2 His 439 knockin (Tph2KI) mouse. In this review, we will critically assess the evidence for 5-HT deficiency in depression and the possible role of polymorphisms in the Tph2 gene as a causal factor in 5-HT deficiency, the latter investigated from a clinical as well as preclinical angle.

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“…Until recently, there has been little awareness in the medical community regarding the severity and prevalence of depression in PD, and as a result, depression in this population remains under-treated. Furthermore, depression and PD have overlapping symptoms that render them difficult to identify and treat (6). For instance, symptoms such as “facial masking” in PD, which limits expression of emotions, may appear to be like flat affect, a characteristic of depression.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, symptoms such as “facial masking” in PD, which limits expression of emotions, may appear to be like flat affect, a characteristic of depression. Bradykinesia due to PD could also be viewed as a feature of depression (6). …”

Section: Introductionmentioning

confidence: 99%

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Mixed Effects of Deep Brain Stimulation on Depressive Symptomatology in Parkinsonâ€™s Disease: A Review of Randomized Clinical Trials

Gökbayrak¹,

Piryatinsky²,

Gavett³

et al. 2014

Front. Neurol.

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Although ~50% of patients with Parkinson’s disease (PD) experience depression, treatment for this important and debilitating comorbidity is relatively understudied. Deep brain stimulation (DBS) has been increasingly utilized for the management of tremors in progressive PD. Several preliminary studies have shown the potential benefit of DBS for non-motor PD symptoms such as depression. Here, we critically evaluate seven recent randomized clinical trials of the effectiveness of DBS in reducing depressive symptomatology among individuals with PD. Findings are mixed for the effectiveness of DBS as a treatment for depression in PD. Our review suggests that this is due, in large part, to the anatomical and methodological variation across the DBS studies. We provide a comprehensive discussion of these variations and highlight the need to conduct larger, more controlled studies aimed specifically at evaluating the treatment of depression in PD patients.

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Prevalence and Treatment of Depression in Parkinson's Disease

Cited by 71 publications

References 0 publications

The Relation of Falls to Fatigue, Depression and Daytime Sleepiness in Parkinson’s Disease

The Relation of Falls to Fatigue, Depression and Daytime Sleepiness in Parkinson’s Disease

The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2^Arg439^Hisknockin mouse

Mixed Effects of Deep Brain Stimulation on Depressive Symptomatology in Parkinsonâ€™s Disease: A Review of Randomized Clinical Trials

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Prevalence and Treatment of Depression in Parkinson's Disease

Cited by 71 publications

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The Relation of Falls to Fatigue, Depression and Daytime Sleepiness in Parkinson’s Disease

The Relation of Falls to Fatigue, Depression and Daytime Sleepiness in Parkinson’s Disease

The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439Hisknockin mouse

Mixed Effects of Deep Brain Stimulation on Depressive Symptomatology in Parkinsonâ€™s Disease: A Review of Randomized Clinical Trials

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The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2^Arg439^Hisknockin mouse