Prevalence and Treatment of Vulvar Cancer From 2014−2018: A Nationwide Population-Based Study in Korea

Ouh, Yung Taek; Kang, Dongwoo; Kim, Ho‐Seob; Lee, Jae Kwan

doi:10.3346/jkms.2022.37.e25

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…Age specific prevalence analysis, according to decade of life, revealed maximum cases (12 out of 47) in eighth decade of life i.e. between 70 to 79 years of age and minimum cases (4/47) in 4 th decade (between 30 to 39 years) of life; which consolidated the outcome of previous study by Ouh et al [20]. No cases in our analysis was below 30 years of age.…”

Section: Discussionsupporting

confidence: 89%

Ten Year Experience of Epidemiological Trends and Clinical Pattern of Vulvar Tumor

Paul,

Soni,

Chatterjee

et al. 2023

Asian Pac J Cancer Care

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Objectives: Vulvar tumor is a relatively uncommon female genito-urinary tumor, occurs mainly in post-menopausal females. Incidence and patterns of vulvar tumor differ from nation to nation, depending upon multiple factors. The aim of this study was to evaluate epidemiological patterns and clinical profile of vulvar tumor in our institution retrospectively. Methods: This is a retrospective study done in a regional cancer centre of India over10-years period. Data of all vulvar tumor patients, regarding demographic profile and tumor characteristics were collected from record section and reviewed. These data were analysed to get an idea about clinic-epidemiological trends of vulvar malignancy. Results: Total 47-patients with biopsy proven vulvar malignancy were found. Mean age at presentation was 63.4 years. Majority of the patients belonged to rural origin, were post-menopausal and multiparous. Most of them had pruritus as typical presenting symptoms. Histopathologically, squamous cell carcinoma constituted the major bulk. Labia was the commonest site of presentation. Bilateralism was found in one-third among them, inguinal lymphadenopathy and extensive disease were found in five and four patients, respectively. Conclusions: The hallmark about the present article is that it was conducted in the only referral cancer institute of this state. Limited studies from different region of India have published local patients’ data on vulvar tumor. A nationwide collaboration in this regard will help to understand the exact burden of this relatively rare malignancy, epidemiological trends and risk factors as well as an idea about how to manage these patients.

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Section: Discussionsupporting

confidence: 89%

Ten Year Experience of Epidemiological Trends and Clinical Pattern of Vulvar Tumor

Paul,

Soni,

Chatterjee

et al. 2023

Asian Pac J Cancer Care

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“…From 2001 to 2017, the incidence rate of vulvar cancer related to human papilloma virus (HPV) in the United States increased by 1.2% every year, especially among women aged 50-69, while the overall incidence rate of non-HPVrelated cancer remained stable [5]. Comparatively, a South Korean population-based study from 2014 to 2018 showed no significant change in the incidence of vulvar cancer during a similar time period [6]. According to the estimation of the American Cancer Association, there will be an estimated 6330 new vulvar cancer cases and 1560 related death in 2022 [1].…”

Section: Introductionmentioning

confidence: 99%

Establishment and validation of a nomogram for estimating the overall survival of vulvar squamous cell carcinoma patients aged 50 years or older

2023

European Journal of Gynaecological Oncology

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This study aimed to develop a nomogram for estimating the overall survival (OS) of vulvar squamous cell carcinoma patients aged ≥50 years based on their clinicopathological characteristics. The Surveillance, Epidemiology and End Results (SEER) database was searched for cases diagnosed with vulvar squamous cell carcinoma from 2000 to 2019. They were randomly grouped into a training and a test cohort in a 7:3 ratio. Cox regression analyses were performed to identify risk factors associated with the overall survival rate of the patients. Then, the nomogram was built based on independent factors selected by the minimum Akaike Information Criterion (AIC) value in multivariate Cox regression analyses. The performance of the nomogram was assessed by its concordance index (C-index) and the area under curve (AUC). Its predictive power was determined by calibration plot and clinical applicability by decision curve analysis (DCA). A total of 3048 patients were identified and randomized into the training (n = 2146) and validation (n = 902) cohort. The validation indicated that the nomogram had good recognition ability for clinical trials, patient counseling, and rationalizing therapeutic modalities. The C-index for OS rates was 0.729 (95%Confidence Interval (CI): 0.715–0.743) in the training cohort and 0.717 (95% CI: 0.693–0.741) in the validation cohort. The AUCs of the 1-, 3- and 5-year OS were 0.789, 0.781 and 0.775 in the training cohort and 0.815, 0.772 and 0.748 in the validation cohort. Calibration plots showed that the nomogram had good predictive power, and DCA demonstrated that the proposed nomogram could provide a net clinical benefit. Our nomogram demonstrated promising accuracy in comprehensively predicting the OS of elderly vulvar squamous cell carcinoma patients. It could be used as a reference to guide individualized treatments and plan the follow-up of elderly patients with vulvar squamous cell carcinoma.

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Pigmented Syringomatous Carcinoma/Sweat Gland Carcinoma of the Vulva With Melanocytic Colonization: An Uncommon Presentation of a Rare Sweat Gland Neoplasm

Shaker,

Alazawi,

Sangueza

2024

The American Journal of Dermatopathology

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Primary vulvar carcinomas are rare and constitute a diverse group of neoplasms. These primary tumors are typically classified based on their presumed tissue of origin or histological characteristics. Among these, carcinomas of sweat gland origin are particularly significant. They closely resemble similar malignancies in nonvulvar skin, including various cutaneous adnexal-type cancers such as apocrine and eccrine adenocarcinomas. Syringomatous carcinoma of the vulva is a rare malignant sweat gland neoplasm known for its infiltrative growth and tendency for local recurrence. Typically, these malignancies manifest as nonulcerated nodules or plaques, primarily in the head and neck region. The occurrence of syringomatous carcinoma in the vulvar region is exceptionally rare. Herein, we present a unique case of a 35-year-old woman with a dark mole measuring 1.5 × 1.0 cm on the vulva. Complete excision was performed to exhibit an infiltrative haphazard proliferation of elongated ductules and tubules, displaying significant cytologic atypia characterized by irregular nuclear contours and variably prominent nucleoli. Extensive melanocytic pigment deposition and stromal fibrosis were also observed. Immunohistochemical staining demonstrated positive expression of epithelial markers, including keratins (AE1/AE3) and epithelial membrane antigen, supporting the diagnosis of syringomatous carcinoma. CK7 and carcinoembryonic antigen were negative, whereas SOX10 and pan melanin highlighted admixed, cytologically bland melanocytes within the epidermis and neoplastic nests. This case represents a highly unusual presentation of syringomatous carcinoma associated with melanocyte colonization. Due to limited data on the optimal management strategies, a multidisciplinary approach involving gynecologic oncologists, dermatopathologists, and radiation oncologists is essential for treatment decisions. Long-term follow-up is crucial, considering the potential for local recurrence and metastatic spread, emphasizing the importance of comprehensive clinical management for favorable patient outcomes of this rare malignancy.

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Prevalence and Treatment of Vulvar Cancer From 2014−2018: A Nationwide Population-Based Study in Korea

Cited by 5 publications

References 35 publications

Ten Year Experience of Epidemiological Trends and Clinical Pattern of Vulvar Tumor

Ten Year Experience of Epidemiological Trends and Clinical Pattern of Vulvar Tumor

Establishment and validation of a nomogram for estimating the overall survival of vulvar squamous cell carcinoma patients aged 50 years or older

Pigmented Syringomatous Carcinoma/Sweat Gland Carcinoma of the Vulva With Melanocytic Colonization: An Uncommon Presentation of a Rare Sweat Gland Neoplasm

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