Prevalence and Trends of Major Transfusion Transmissible Infections among Blood Donors in Dire Dawa Blood bank, Eastern Ethiopia: Retrospective Study

Ataro, Zerihun; Urgessa, Fekadu; Wasihun, Tagesachew

doi:10.4314/ejhs.v28i6.4

Cited by 24 publications

(22 citation statements)

References 17 publications

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“…4 The current study indicated that the overall seropositivity of TTIs among voluntary blood donors was 7.0%. This is in line with the reports of previous studies that were conducted in different regions of Ethiopia: 7.0% in Yirgalem, 17 7.06% in Dire Dawa, 18 6.6% in Harari, 19 and 6% in Bahir Dar. 20 On the contrary, the rate was lower than the reports of several studies conducted in Ethiopia and Africa settings like 12.4% in Eastern Ethiopia, 21 11.5% in Jigjiga, 9 12.6% in South Gondar, 22 10.1% in Zambia, 23 15.9% in Tanzania, 24 18.9% in Ghana, 25 26.2% in Cameroon, 26 and 19.3 % in Nigeria.…”

Section: Discussionsupporting

confidence: 93%

“…In addition, the sensitivity and specificity levels of the diagnostic kits might have a contribution to the variations of seropositivity rates between the studies. Studies conducted in different regions of Ethiopia revealed different seropositivity rate of HIV and HCV: 1.24% and 0.96% in Dire Dawa, 18 0.5% and 0.6% in Bahir Dar, 20 2.6% and 4.2 % in South Gondar, 22 and 1.4% and 1% in Eastern Ethiopia. 21 On the contrary, we found that none of the blood donors were positive for HIV and HCV.…”

Section: Discussionmentioning

confidence: 99%

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Blood transfusion-transmissible malaria and its cost analysis in Hawassa regional blood bank, Southern Ethiopia

et al. 2020

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Background: Blood transfusion is an intervention used to save life particularly for those patients who survive only with receiving blood. Establishing effective diagnostic test menus concerning the screening of transfusion-transmissible infections in the blood banks play a vital role to safeguard recipients from transfusion-transmissible infections. Objective: The aim of this study was to assess blood transfusion-transmissible malaria and its screening cost analysis in Hawassa regional blood bank, Hawassa, Sothern Ethiopia. Methods: An institutional-based cross-sectional study was conducted from April to May 2018 among 414 voluntary blood donors. Each participant’s blood sample was screened for most transfusion-transmissible infections using antigen/antibody tests, while rapid diagnostic test and microscopy were used for malaria screening and confirmation. In addition, the cost screening of transfusion-transmissible infections was calculated using activity-based costing method. Results: The overall seropositivity of transfusion-transmissible infections was 7.0% and the positivity rate of hepatitis B virus, syphilis, and Plasmodium falciparum was 5.6%, 1.0%, and 0.5%, respectively. The cost per test of each transfusion-transmissible infection was US$5.04 for human immunodeficiency virus, US$4.61 for hepatitis B virus, US$5.11 for hepatitis C virus, and US$4.75 for syphilis, while the cost per test of malaria rapid diagnostic test was US$4.74 and this is comparatively lower than the cost per test of other transfusion-transmissible infections except for hepatitis B virus. In addition, total cost of laboratory incurred for transfusion-transmissible infections screening is estimated to be US$213,634.5 per year, while it becomes US$265,537.5 if the malaria screening cost is added. This means 19.54% of the total cost of laboratory incurred per year or US$51,903. Conclusion: The positivity rate of malaria parasites among voluntary blood donors was 0.5%, and it might be increased if the study was conducted in high transmission seasons. A cost of malaria screening is comparatively lower than costs of other transfusion-transmissible infections except for hepatitis B virus. Therefore, the screening of malaria parasites should be considered as one of the test menus of transfusion-transmissible infections in blood banks, especially in malaria-endemic areas.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Blood transfusion-transmissible malaria and its cost analysis in Hawassa regional blood bank, Southern Ethiopia

et al. 2020

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“…Of all included studies, 36 reported HBV [ 3 , 13 , 29 – 62 ]; 34 reported HIV [ 3 , 13 , 29 – 33 , 35 – 38 , 42 , 43 , 45 , 46 , 48 – 58 , 60 – 68 ]; 31 reported HCV [ 3 , 13 , 29 – 33 , 35 – 38 , 41 – 43 , 45 – 51 , 54 , 55 , 57 , 58 , 60 – 62 , 69 , 70 ]; and 23 reported syphilis [ 3 , 13 , 29 – 31 , 33 , 35 , 36 , 38 , 42 , 43 , 45 , 46 , 49 – 52 , 54 , 57 , 58 , 60 , 68 , 71 ] prevalence among blood donors in Ethiopia. Regarding the distribution of each TTIs with sex and donor type of the study participants, it was found as follows: of 36 studies reported HBV, 24 and 9 reported sex and donor type, respectively; of 34 studies reported HIV, 24 and 8 studies reported sex and donor type, respectively; of 31 reported HCV, 19 and 7 reported sex and donor type, respectively; and of 23 studies reported syphilis, 14 and 5 studies reported sex and donor type, respectively (Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Sero-epidemiology and associated factors of HIV, HBV, HCV and syphilis among blood donors in Ethiopia: a systematic review and meta-analysis

et al. 2021

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Background Transfusion transmissible infections (TTIs) remain a major public health problem in developing countries including Ethiopia. In Ethiopia, comprehensive information about sero-epidemiology of major TTIs is lacking at the national level. Therefore, this systematic review and meta-analysis was aimed at providing the pooled estimate of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis among blood donors in Ethiopia. Methods Relevant studies published until May 31, 2019 were searched through PubMed/Medline, EMBASE, SCOPUS, HINARI, Cochrane database library, Web of Science, Google Scholar and Google. The methodological quality of articles was assessed using Joanna Brigg’s Institute critical appraisal checklist for prevalence and analytical studies. The pooled sero-epidemiology of HIV, HBV, HCV and syphilis were determined using the random-effects model. Heterogeneity between the studies was assessed using the I2 statistics. Publication bias was assessed by visual inspection of the funnel plot and Egger's statistics. Results A total of 7921 articles were retrieved, and 7798 were screened for eligibility after duplicates removed. Forty-nine full-text articles were assessed for eligibility; of which 45 were eligible for qualitative and quantitative synthesis: categorized as 36, 34, 31 and 23 studies for estimations of HBV, HIV, HCV and syphilis, respectively. In the random-effects model, the pooled sero-epidemiology of HBV, HIV, HCV and syphilis was 5.20, 2.83, 0.93 and 1.50%, respectively. Moreover, being a male blood donor was significantly associated with HBV and syphilis infection, whereas being a replacement blood donor was significantly associated with a high burden of HIV, HBV and HCV infections. Conclusion The pooled sero-epidemiology of major TTIs among blood donors was high. Therefore, there is a need to design prevention and control strategies in a comprehensive approach to reduce the burden.

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“…In addition, the qualities of each of the included studies was evaluated using the nine items risk of bias assessment tool (Table 1). [80] 2016 Somali Blood donor Entire sampling Abera B., et al [79] 2017 Amhara HIV positive children Random sampling Abera B., et al [78] 2014 Amhara Apparently healthy Random sampling Akalu GT., et al [77] 2016 SAC Healthcare workers Convenient sampling Amsalu A., et al [76] 2018 SNNPR Pregnant women Consecutive sampling Anagaw B., et al [75] 2012 Amhara Waste handlers Unknown Asfaw MA., et al [74] 2018 SNNPR VCT Random sampling Ataro Z., et al [73] 2018 SAC Blood donors Entire sampling Ayele AG., et al [72] 2013 SAC Chronic liver diseases Convenient sampling Balew M., et al [71] 2014 Amhara HIV positive Random sampling Belayneh F., [70] 2015 SNNPR HIV positive adult Consecutive sampling Betela B., et al [87] 2018 Oromia General population Random sampling Biadgo B., et al [69] 2017 Amhara Blood donors Entire sampling Bialfew Y., et al [68] 2018 Amhara Blood donors Consecutive sampling Birku T., et al [67] 2015 Amhara Military personnel Random sampling Bisetegen FS., et al [66] 2016 SNNPR Blood donors Consecutive sampling Chernet A., et al [65] 2017 SNNPR Pregnant women Entire sampling Dabsu R., et al [64] 2014 Oromia Pregnant women Convenient sampling Demsiss W., et al [63] 2018 Amhara Students Random sampling Deressa T., et al [20] 2017 Amhara HIV positive Random sampling Deressa T., et al [62] 2018 Amhara Blood donors Entire sampling Desalegn Z., et al [84] 2013 SAC Healthcare workers Convenient sampling Desalegn Z., et al [83] 2016 Oromia Pregnant women Entire sampling Erena AN., et al [61] 2014 Oromia General population Random sampling G/micheal A., et al [60] 2013 Oromia Healthcare workers Random sampling G/egziabher D., et al [59] 2016 SAC General population Entire sampling G/mariam AA., et al [58] 2019 Amhara Healthcare professional Entire sampling Habte Y., et al [57] 2016 SAC ...…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

An updated systematic review and meta-analysis of the prevalence of hepatitis B virus in Ethiopia

Yazie

Tebeje

2019

Preprint

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Background: Hepatitis B virus is one of the major public health concerns globally. It is highly infectious and can be transmitted from person to person through vertically or horizontally via contaminated body fluids. Despite the provision of an effective vaccine, it remains a major problem worldwide, particularly among the developing countries. Methods: Online electronic databases including PubMed, Google Scholar, Science Direct, African Index Medicus, African Journals Online, and WHO Afro Library were searched and published articles from 2010 to June 8, 2019, were considered. Both authors independently screened articles and extracted the data. Funnel-Plots and Egger’s test statistics were used to determine the presence of small-study effects and publication bias. The pooled prevalence of HBV was analyzed using the random-effects model. The possible sources of heterogeneity was analyzed through subgroup analysis, sensitivity analysis, and meta-regression. Results: The overall pooled prevalence of HBV was 6% and among subgroups, pregnant women, healthcare workers, and HIV positive patients accounted for 5% for each group. Relatively low prevalence (4%) was obtained among blood donors. The Egger’s test statistics ( p =0.747) indicated the absence of publication bias. In addition, from the sensitivity analysis, there was no influence on the overall effect estimate while removing a single study at a time. The level of heterogeneity was reduced among pregnant women, HIV positive and studies with unknown sampling techniques. After conducting meta-regression, province, study group, screening method, and quality of papers were identified as sources of heterogeneity. Conclusions: The overall pooled prevalence of HBV in Ethiopia was high. Strengthening and scaling up of the scope of the existing vaccination program and implementing novel approaches including screen-and-treat could be implemented to reduce the burden of the disease. Generally, the study can provide current prevalence estimate of HBV that could vital for intervention to tackle the disease.

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Prevalence and Trends of Major Transfusion Transmissible Infections among Blood Donors in Dire Dawa Blood bank, Eastern Ethiopia: Retrospective Study

Cited by 24 publications

References 17 publications

Blood transfusion-transmissible malaria and its cost analysis in Hawassa regional blood bank, Southern Ethiopia

Blood transfusion-transmissible malaria and its cost analysis in Hawassa regional blood bank, Southern Ethiopia

Sero-epidemiology and associated factors of HIV, HBV, HCV and syphilis among blood donors in Ethiopia: a systematic review and meta-analysis

An updated systematic review and meta-analysis of the prevalence of hepatitis B virus in Ethiopia

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