Prevalence and typing of HPV DNA by hybrid capture II in women with ASCUS, ASC‐H, LSIL, and AGC on ThinPrep® Pap tests

Rowe, Leslie R.; Aldeen, William E.; Bentz, Joel S.

doi:10.1002/dc.20052

Cited by 29 publications

(23 citation statements)

References 39 publications

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“…11 The frequency of HPV positivity among women with ASC-H cytology has been reported with a range of 38% to 84%. 5,[12][13][14][15][16][17] We found in our cohort that 64% of women with ASC-H had a positive HR-HPV test, which is lower than that obtained in the ALTS study (84%). 5 The rate of HR-HPV positivity in women with ASC-H can be varied among different age groups.…”

Section: Discussioncontrasting

confidence: 80%

HPV testing results and histologic follow-up in women with ASC-H cytology in different age groups

Chen

Baker

Petris

et al. 2015

Journal of the American Society of Cytopathology

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Section: Discussioncontrasting

confidence: 80%

HPV testing results and histologic follow-up in women with ASC-H cytology in different age groups

Chen

Baker

Petris

et al. 2015

Journal of the American Society of Cytopathology

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“…In previous studies, HPV was reported in 29%-61% in women with abnormal cytology results (21,22,23,24,25,26). In our study, the rate of HPV positivity in women with normal cervical cytology was 27%, refl ecting hospital based patients' accrual.…”

Section: Resultsmentioning

confidence: 89%

HPV types in Turkey: multicenter hospital based evaluation of 6388 patients in turkish gynecologic oncology group centers

Dursun¹,

Ayhan²,

Mutlu³

et al. 2013

TJPATH

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Objective: To evaluate the prevalence of HPV DNA and cervical cytological abnormalities, to compare cervical cytology results and HPV DNA and to define HPV types distribution in a large series of Turkish women who have undergone HPV analysis in hospitals that are members of the Turkish Gynecological Oncology Group. Material and Method:Between 2006 and 2010, a total of 6388 patients' data was retrospectively evaluated at 12 healthcare centers in Turkey. Demographic characteristics, cervical cytology results, HPV status and types were compared.Results: Th e mean age of the patients was 38.9±10.2. Overall, 25% of the women were found to be HPV positive. Presence of HPV-DNA among patients with abnormal and normal cytology was 52% and 27%, respectively. Th ere was significant diff erence with respect to decades of life and HPV positivity (p < 0.05). HPV was positive in (within the HPV (+) patients) 37%, 9%, 27%, 20%, 22%, and 41% of the ASCUS, ASC-H, LSIL HSIL, glandular cell abnormalities, and SCC cases respectively Th e most common HPV types in our study were as follows; HPV 16 (32%), HPV 6 (17%), HPV 11 (9%), HPV 18 (8%), HPV 31 (6%), HPV 51 (5%), HPV 33 (3%). Conclusion:In this hospital based retrospective analysis, HPV genotypes in Turkish women with normal and abnormal cytology are similar to those reported from western countries. Further population based prospective multicenter studies are necessary to determine non-hospital based HPV prevalence in Turkish women. Bulgular: Ortalama hasta yaşı 38.9±10.2 idi. Tüm grup değerlendiril-diğinde, %25 hastada HPV pozitif olarak saptandı. Anormal sitolojisi olanlarda HPV pozitifl iği %57 iken normal pap testi olanlarda HPV pozitifl iği %27 oranında tespit edildi. Hastaların yaşam dekadları ile HPV pozitifl iği arasında anlamlı bir ilişki bulundu (p<0,05) HPV pozitifl iği ASCUS, ASC-H, LSIL, HSIL, glandüler anormallikler ve skuamöz hücreli karsinom için sırasıyla %37, %9, %27, %20, %22, %41 idi. En sık görülen HPV tipleri sırasıyla HPV 16 (%32), HPV 6 (%17), HPV 11 (%9), HPV 18 (%8), HPV 31 (%6), HPV 51 (%5), HPV 33 (%3) idi.Sonuç: Bu hastane temelli retrospektif analizde HPV tipleri gelişmiş batı ülkelerinde rapor edilen tiplerle benzer olarak tespit edildi. Ülkemizdeki gerçek popülasyon temelli HPV prevalansı ve tiplerinin belirlenmesi için hastane temelli olmayan çok merkezli geniş sayıda hasta içeren serilere ihtiyaç vardır.

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“…ASCUS cytology indicated that cytological-morphological changes were not benign; however, this did not meet the criteria for classification as squamous lesions, even though studies have shown that this type of cytological interpretation is highly related to characteristic subjective reading of Pap tests [37,38]. …”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus detection in women with and without human immunodeficiency virus infection in Colombia

et al. 2014

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BackgroundHIV infection leads to a decreasing immune response, thereby facilitating the appearance of other infections, one of the most important ones being HPV. However, studies are needed for determining associations between immunodeficiency caused by HIV and/or the presence of HPV during the course of cervical lesions and their degree of malignancy. This study describes the cytological findings revealed by the Papanicolaou test, laboratory characteristics and HPV molecular profile in women with and without HIV infection.MethodsA total of 216 HIV-positive and 1,159 HIV-negative women were invited to participate in the study; PCR was used for the molecular detection of HPV in cervical samples. Statistical analysis (such as percentages, Chi-square test and Fisher’s exact test when applicable) determined human papillomavirus (HPV) infection frequency (single and multiple) and the distribution of six types of high-risk-HPV in women with and without HIV infection. Likewise, a logistic regression model was run to evaluate the relationship between HIV-HPV infection and different risk factors.ResultsAn association was found between the frequency of HPV infection and infection involving 2 or more HPV types (also known as multiple HPV infection) in HIV-positive women (69.0% and 54.2%, respectively); such frequency was greater than that found in HIV-negative women (44.3% and 22.7%, respectively). Statistically significant differences were observed between both groups (p = 0.001) regarding HPV presence (both in infection and multiple HPV infection). HPV-16 was the most prevalent type in the population being studied (p = 0.001); other viral types had variable distribution in both groups (HIV-positive and HIV-negative). HPV detection was associated with <500 cell/mm3 CD4-count (p = 0.004) and higher HIV-viral-load (p = 0.001). HPV-DNA detection, <200 cell/mm3 CD4-count (p = 0.001), and higher HIV-viral-load (p = 0.001) were associated with abnormal cytological findings.ConclusionsThe HIV-1 positive population in this study had high multiple HPV infection prevalence. The results for this population group also suggested a greater association between HPV-DNA presence and cytological findings. HPV detection, together with low CD4 count, could represent useful tools for identifying HIV-positive women at risk of developing cervical lesions.

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Prevalence and typing of HPV DNA by hybrid capture II in women with ASCUS, ASC‐H, LSIL, and AGC on ThinPrep® Pap tests

Cited by 29 publications

References 39 publications

HPV testing results and histologic follow-up in women with ASC-H cytology in different age groups

HPV testing results and histologic follow-up in women with ASC-H cytology in different age groups

HPV types in Turkey: multicenter hospital based evaluation of 6388 patients in turkish gynecologic oncology group centers

Human papillomavirus detection in women with and without human immunodeficiency virus infection in Colombia

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