Prevalence, Antimicrobial Susceptibility Pattern and Risk Factors of Mrsa Isolated From Clinical Specimens Among Military Patients at 48 Medical Compound in Sana'a City-Yemen

Abstract

Methicillin-resistant strains of S. aureus evolved in the 1970 and have troubled hospitals worldwide with persistent infections in patients. The objectives of this study were to determine the prevalence, antimicrobial susceptibility pattern and risk factors of MRSA isolated from clinical specimens among military patients at 48 Medical Compound in Sana'a city -Yemen. The study included 233 patients of whom suffering from Staphylococcus aureus infections. Specimens and data collected from November 2016 to November 2017. Standard methods of isolation and identifications were used to isolate bacteria in pours culture then Staphylococcus aureus were identifying using standard cultural techniques. MRSA was determined by the disc diffusion method to oxacillin and antimicrobial susceptibility testing was performed by the disc diffusion method for selected antibiotics. The prevalence rate of MRSA was 19.3% and there was significant association between MRSA and older age patients, and surgical site infections. There was higher rate of antibiotics resistant for tested antibiotics in MRSA isolates comparing with lower rate of antibiotics resistant in MSSA. 60% of the MRSA isolates were resistant to vancomycin. They were also susceptible to erythromycin and rifampicin (100%), but showed resistance to Cotrimoxazole and Gentamycine. In conclusion, the emergence of S. aureus isolates resistant to vancomycin and other wide range of antibiotics have raised MRSA in Yemen into a multi-drugresistant 'Superbug", making it more and more dangerous than ever in our hospital environments. Regular surveillance of hospital associated infections and monitoring antibiotic sensitivity pattern and strict drug policy for antibiotics used within and outside the hospital environments are recommend. Keywords: MRSA, MSSA, MDR, Superbug, Sana'a city, Yemen.Article Info: Received 20 June 2018; Revised 29 June; Accepted 5 July, Available online 15 July 2018Cite this articleAl-Safani AMA, Al-Shamahy HA, Al-Moyed KA. Prevalence, antimicrobial susceptibility pattern and risk factors of MRSA isolated from clinical specimens among military patients at 48 medical compound in Sana'a city-Yemen.

Patterns of Antimicrobial Resistance Among Major Bacterial Pathogens Isolated From Clinical Samples in Two Tertiary’s Hospitals, in Sana'a, Yemen

“…if CoNS was isolated from the skin or soft tissue bacterial culture of a suspected infectious lesion, the isolated organism should be suggested as the pathogen and appropriate treatment should be started [43][44][45] . Among the antibiotics tested differently, the results of current study showed that the rate of resistance to linezolid was very low (0.42%) (Table 3) making it highly efficient antibiotics against Enterococcus spp and S. aureus which it was in accord with the rates previously described by Al-Safani et al, 20 32 . Overall, the results of the current study showed that sulfamethoxazole/trimethoprim, ceftazidime, ampicillin, ceftorexime and cefotaxime are ineffective antibiotics against GPB or GNB.…”

“…According to estimates by the World Health Organization (WHO) and United Nations report, deaths due to antimicrobial resistance could increase with the time 4, 5 . Nowadays, antimicrobial resistance (AMR) is a major public health threat, 6,7 and antimicrobial resistance bacteria in different hospital departments are increasing dramatically all over the world and in Yemen this problem is more extensive and complex [8][9][10][11][12][13][14][15][16][17][18][19][20] . As for some details of the previous work in Yemen, these studies mostly focused on studying the sensitivity to antibiotics for each bacteria separately 8-20 , while the current study studied the resistance to all bacterial isolates, and the current study also identified the temporal correlation of the rate of increase in the prevalence of resistance of bacterial isolates to the antibiotics used in the study area.…”

“…19,20,27 . The application of several classes of antibiotics is not permitted in neonates and children and because there are different patterns of…”

Prevalence of Staphylococcus Aureus in Dental Infections and the Occurrence of Mrsa in Isolates

“…Many bacterial diseases occur in hospitals and in community due to MRSA strains and sometimes lead to death 10-12 . S. aureus infection, including MRSA strains, has long been common in Yemen 13 . Because the arbitrary use of antibiotics is a typical practice, hospital environments are not clean enough and crowding of patients and health workers supports the spread of infectious germs including S. aureus 13 .…”

Childhood Urinary Tract Infection: Clinical Signs, Bacterial Causes and Antibiotic Susceptibility

“…An example of the importance of this topic in Sana'a and the situation where this information is useful in Sana'a as well. As the rates of antibiotic resistance are high, doctors depend on giving antibiotics experimentally without bacterial isolation and sensitivity testing to antibiotics [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] . Treatment for UTIs often begins with an experiment.…”