Prevalence, awareness, treatment and control of type 2 diabetes and its determinants among Mongolians in China: a cross-sectional analysis of IMAGINS 2015–2020

Duan, Mingrui; Xi, Yunfeng; Tian, Qiuyue; Na, Buqi; Han, Ke; Zhang, Xingguang; Wang, Wenrui; Zheng, Deqiang; Wang, Youxin

doi:10.1136/bmjopen-2022-063893

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…The proportion of Inner Mongolia's population aged over 35 years old with diabetes was found to be 17.2% in recent studies conducted in the region of Mongolia. (Duan M et al 2022 . That means there is a higher prevalence rate of T2D in the Mongolian of the Inner Mongolia, China.…”

Section: Introductionmentioning

confidence: 99%

The Metabolic Functional Feature of Gut Microbiota in Mongolian Patients with Type 2 Diabetes

Liu,

Pang,

et al. 2024

J. Microbiol. Biotechnol.

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The accumulating evidence substantiates the indispensable role of gut microbiota in modulating the pathogenesis of type 2 diabetes. Uncovering the intricacies of the mechanism is imperative in aiding disease control efforts. Revealing key bacterial species, their metabolites and/or metabolic pathways from the vast array of gut microorganisms can signi cantly contribute to precise treatment of the disease. With a high prevalence of type 2 diabetes in Inner Mongolia, China, the Mongolian population was selected as subjects to investigate the relationship between gut microbiota and the disease. We recruited Volunteers of Mongolian with type 2 diabetes and control group and detected their fecal samples by metagenomic analysis and untargeted metabolomics analysis. The ndings suggest that Firmicutes and Bacteroidetes phyla are the predominant gut microorganisms that exert signi cant in uence on the pathogenesis of type 2 diabetes in Mongolian population. In the disease group, despite an increase in the quantity of most gut microbial metabolic enzymes, there was a concomitant weakening of gut metabolic function, suggesting that the gut microbiota may be in a compensatory state during the disease stage. The beta-Tocotrienol may serve as a pivotal gut metabolite produced by gut microorganisms and a potential biomarker for type 2 disease. The metabolic pathway of Ubiquinone and other terpenoidquinone biosynthesis could be the crucial mechanism through which the gut microbiota regulates type 2 diabetes.Additionally, certain Clostridium gut species may play a pivotal role in the progression of the disease. Key Points•Clostridium genus is a main source of the key bacterial species to regulate T2D.•In T2D stage, there is a reduction in gut metabolic function.•Beta-Tocotrienol and its metabolic pathway may be the one of the keys to regulate T2D.

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Section: Introductionmentioning

confidence: 99%

The Metabolic Functional Feature of Gut Microbiota in Mongolian Patients with Type 2 Diabetes

Liu,

Pang,

et al. 2024

J. Microbiol. Biotechnol.

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“…China is a country with the largest number of diabetic patients, which brings a serious economic burden [ 1 ]. According a new survey, the T2D prevalence of Mongolian population in Inner Mongolia of China was 17.2%[ 2 ], that is a high rate comparing with the global average-level. Studies of the cause of T2D will be beneficial to the prevention and treatment of this disease.…”

Section: Introductionmentioning

confidence: 99%

Differences in gut microbiota and its metabolic function among different fasting plasma glucose groups in Mongolian population of China

Yanchao

Wang

et al. 2023

BMC Microbiol

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Background Many studies reported the association between gut microbiota and type 2 diabetes mellitus (T2D), but it is still unclear which bacterial genus plays a key role and how the metabolic function of gut microbiota changes in the occurrence and development of T2D. Besides, there is a high diabetic prevalence in Mongolian population, which may be partly affected by their high calorie diet. This study identified the main bacterial genus influencing T2D in Mongolian population, and analyzed the changes of metabolic function of gut microbiome. The association between dietary factors and the relative abundance of main bacterial genus and its metabolic function was also studied. Methods Dietary surveys and gut microbiota test were performed on 24 Mongolian volunteers that were divided into T2D (6 cases), PRET2D (6 cases) and Control group (12 cases) according to fasting plasma glucose (FPG) values. The relative abundance and metabolic function of gut microbiome from their fecal samples were measured by metagenomic analysis. Statistic method was used to evaluate the association between dietary factors and the relative abundance of the main bacterial genus or its metabolic function. Results This study found that the Clostridium genus may be one of the key bacterial genera affecting the process of T2D. First, the relative abundance of Clostridium genus was significantly different among the three groups. Second, there was a higher relative abundance of metabolic enzymes of gut bacteria in PRET2D and T2D group than that in Control group. Third, a strong correlation between Clostridium genus and many metabolic enzymes was uncovered, many of which may be produced by the Clostridium. Last, carotene intake daily was negatively correlated with the Clostridium but positively correlated with tagaturonate reductase catalyzing interconversions of pentose and glucuronate. Conclusions The gut Clostridium genus may play an important role in the development of T2D and it could be a potential biomarker for T2D in Mongolian population. Meanwhile, the metabolic function of gut bacteria has changed during the early stage of T2D and the changes in carbohydrate, amino acid, lipid or energy metabolism of Clostridium genus may play a critical role. In addition, the carotene intake may affect reproduction and metabolic function of Clostridium genus.

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The metabolic functional feature of gut microbiota in Mongolian patients with type 2 diabetes

Liu

Gao

Zhao

et al. 2023

Preprint

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The accumulating evidence substantiates the indispensable role of gut microbiota in modulating the pathogenesis of type 2 diabetes. Uncovering the intricacies of the mechanism is imperative in aiding disease control efforts. Revealing key bacterial species, their metabolites and/or metabolic pathways from the vast array of gut microorganisms can significantly contribute to precise treatment of the disease. With a high prevalence of type 2 diabetes in Inner Mongolia, China, the Mongolian population was selected as subjects to investigate the relationship between gut microbiota and the disease. We recruited Volunteers of Mongolian with type 2 diabetes and control group and detected their fecal samples by metagenomic analysis and untargeted metabolomics analysis. The findings suggest that Firmicutes and Bacteroidetes phyla are the predominant gut microorganisms that exert significant influence on the pathogenesis of type 2 diabetes in Mongolian population. In the disease group, despite an increase in the quantity of most gut microbial metabolic enzymes, there was a concomitant weakening of gut metabolic function, suggesting that the gut microbiota may be in a compensatory state during the disease stage. The beta-Tocotrienol may serve as a pivotal gut metabolite produced by gut microorganisms and a potential biomarker for type 2 disease. The metabolic pathway of Ubiquinone and other terpenoid-quinone biosynthesis could be the crucial mechanism through which the gut microbiota regulates type 2 diabetes. Additionally, certain Clostridium gut species may play a pivotal role in the progression of the disease.

show abstract

Prevalence, awareness, treatment and control of type 2 diabetes and its determinants among Mongolians in China: a cross-sectional analysis of IMAGINS 2015–2020

Cited by 3 publications

References 30 publications

The Metabolic Functional Feature of Gut Microbiota in Mongolian Patients with Type 2 Diabetes

The Metabolic Functional Feature of Gut Microbiota in Mongolian Patients with Type 2 Diabetes

Differences in gut microbiota and its metabolic function among different fasting plasma glucose groups in Mongolian population of China

The metabolic functional feature of gut microbiota in Mongolian patients with type 2 diabetes

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